Ecolink

General characteristics. Structure:

Active agent: lincomycin (in the form of a monohydrate hydrochloride) 250 mg

Excipients: lactulose - 300 mg, povidone low-molecular - 10 mg, talc - 10 mg, magnesium stearate - 5 mg, potato starch - to 650 mg.

Structure of a cover of the capsule: gelatin, water, titanium dioxide, dye quinolinic yellow, dye sunset yellow.

Pharmacological properties:

The antibiotic produced by Streptomyces lincolniensis has bacteriostatic action. Suppresses proteinaceous synthesis of bacteria owing to reversible binding with 50S in subunit of ribosomes, breaks formation of peptide bonds.
It is active concerning gram-positive cocci (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.
It is effective concerning Staphylococcus spp., steady against penicillin, tetracyclines, chloramphenicol to streptomycin, cephalosporins (30% of Staphylococcus spp., steady against erythromycin, have cross lincomycin resistance).
Does not affect Enterococcus spp. (including Enterococcus faecalis), gram-negative microorganisms, mushrooms, viruses, the elementary; concedes on activity to erythromycin concerning spore-forming anaerobe bacterias, Neisseria spp., Corynebacterium spp.
The optimum of action is in the alkaline environment (рН 8-8.5). Lincomycin resistance develops slowly. In high doses has bactericidal effect.

Pharmacokinetics. Absorption - 30-40% (meal slows down the speed and extent of absorption). Time of achievement of Cmax - 2-3 h. Well gets into tissues of lungs, a liver, kidneys, through a placental barrier, into breast milk; in high concentration it is found in a bone tissue and joints. Through a blood-brain barrier lincomycin gets slightly, at meningitis - permeability increases.
It is partially metabolized in a liver. T1/2 is 5 h. It is removed in not changed look and in the form of metabolites with bile and kidneys.

Indications to use:

The infectious and inflammatory diseases caused by sensitive microorganisms (first of all, stafilokokka and streptococci, especially the microorganisms steady against penicillin, and also at an allergy to penicillin):
— sepsis;
— subacute septic endocarditis;
— chronic pneumonia;
— lung abscess;
— pleura empyema;
— pleurisy;
— otitis;
— osteomyelitis (acute and chronic);
— purulent arthritis;
— postoperative purulent complications;
— wound fever;
— infections of skin and soft tissues (pyoderma, furunculosis, phlegmon, erysipelatous inflammation).

Route of administration and doses:

Inside, for 1-2 h to or in 2-3 h after food, 2-3 times a day with an interval of 8-12 hours. For adults a daily dose - 1-1,5 g, one-time - 0,5 g. For children aged from 3 up to 14 years a daily dose - 30-60 mg/kg.
Treatment duration depending on a form and disease severity makes 7-14 days (at osteomyelitis - 3 weeks and more).
At long or repeated courses treatment should be carried out under control of function of a liver and kidneys.

Features of use:

Against the background of prolonged treatment periodic control of activity of "hepatic" transaminases and function of kidneys is necessary.

Appointment to patients with a liver failure is admissible only according to "vital" indications.

At emergence of signs of a pseudomembranous coloenteritis (diarrhea, a leukocytosis, fever, an abdominal pain, allocation with a fecal mass of blood and slime) in mild cases there is enough drug withdrawal and purpose of ion-exchange resins (Colestyraminum), in hard cases compensation of loss of liquid, electrolytes and protein, Vancomycinum - inside, in a daily dose of 0.5-2 g (for 3-4 receptions) within 10 days or bacitracin is shown.

Side effects:

From the alimentary system: nausea, vomiting, diarrhea, pains in epigastriums, an abdominal pain, a glossitis, stomatitis, a tranzitorny hyperbilirubinemia, increase in activity of "hepatic" transaminases; at prolonged use - GIT candidiasis, a pseudomembranous coloenteritis.
Other fungal infections of a genital path.
From bodies of a hemopoiesis: reversible leukopenia, thrombocytopenia, neutropenia.
Allergic reactions: urticaria, exfoliative dermatitis, Quincke's disease, acute anaphylaxis.

Interaction with other medicines:

Antagonism - with erythromycin, chloramphenicol, ampicillin, and other bactericidal antibiotics, a synergism with aminoglycosides.

Antidiarrheal medicines reduce effect of lincomycin (the interval between their use has to make not less than 4 h).

Strengthens effect of medicines for an inhalation anesthesia, muscle relaxants and opioid analgetics, increasing risk of neuromuscular blockade and an apnoea.

At simultaneous use with lincomycin, P450 inhibitor, serumal concentration of theophylline can increase and it will demand decrease in its dose.

Contraindications:

— hypersensitivity;
— pregnancy (except for cases, when necessary according to "vital" indications),
— lactation period;
— heavy liver and/or renal failure;
— children's age up to 3 years.

With care: fungus diseases of skin, mucous membrane of an oral cavity, vagina.

Use of the drug EKOLINKOM® at pregnancy and feeding by a breast
Contraindicated during pregnancy except for cases, when necessary according to "vital" indications.
Use in the period of a lactation is contraindicated.

Use at abnormal liver functions
Contraindicated at a heavy liver failure.
Appointment to patients with a liver failure is admissible only according to "vital" indications.

Use at renal failures
Contraindicated at a heavy renal failure.
Against the background of prolonged treatment periodic control of activity of "hepatic" transaminases and function of kidneys is necessary.

Use for children
Contraindicated to children up to 3 years.

Overdose:

There are no data on drug overdose.

Storage conditions:

List B. In the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Капс. 250 mg: 10 or 20 pieces.