Antioxidant complex

General characteristics. Structure:

Active ingredient: 100 mg of ascorbic acid, 100 mg of alpha tocopherol of acetate, 33 000 ME of Retinolum of acetate.

Vitamin complex with the expressed antioxidant action.

Pharmacological properties:

Pharmacodynamics. Pharmacological activity of a complex of vitamins is caused by its expressed antioxidant action. Considerably improves power security of an organism, increases its antineoplastic resistance, possesses the expressed radio protective action and promotes recovery of the irradiated fabrics, growth of tumors and processes of innidiation detains, increases antineoplastic activity of himiopreparat with simultaneous decrease in their toxicity.

Ascorbic acid (vitamin C) is not formed in a human body, and arrives only with food. Pharmacological effects: in the quantities considerably exceeding daily requirement (90 mg) has almost no effect, except for bystry elimination of symptoms hypo - and avitaminosis (scurvy). Physiological functions: is a cofactor of some reactions of a hydroxylation and amidation - transfers electrons to enzymes, supplying them with a recovery equivalent. Participates in reactions of a hydroxylation of the prolinovy and lizinovy remains of procollagen with formation of hydroxyproline and hydroxylysine (collagen post-translational modification), oxidation of side chains of a lysine in proteins with formation of a gidroksitrimetillizin (in the course of synthesis of a kartinit), oxidation of folic acid to folinovy, metabolism of medicines in microsomes of a liver and a hydroxylation of dopamine with formation of noradrenaline. Increases activity of the amidating enzymes participating in processing of oxytocin, ADG and cholecystokinin. Participates in a steroidogenesis in adrenal glands. Recovers Fe3 + to Fe2 + in intestines, promoting its absorption. The main role in fabrics - participation in synthesis of collagen, proteoglycans, etc. organic components of intercellular substance of teeth, bones and endothelium of capillaries. In low doses (150-250 mg/days inside) improves complexing function of Deferoxaminum at chronic intoxication the drugs Fe that leads to strengthening of excretion of the last.

Tocopherol – fat-soluble vitamin which function up to the end remains obscure. As antioxidant, slows down development of free radical reactions, prevents formation of the peroxides damaging cellular and subcellular membranes that is important for development of an organism, normal function of nervous and muscular systems. Together with selenium slows down oxidation of unsaturated fatty acids (a component of microsomal system of transfer of electrons), prevents hemolysis of erythrocytes. Is a cofactor of some fermental systems.

Retinolum is a necessary component for normal function of a mesh cover of an eye: it contacts opsin, forming rhodopsin the rhodopsin necessary for twilight sight. Vitamin A participates in regulation of division and a differentiation of an epithelium (strengthens an epithelium differentiation, stimulates formation of secretory cells, slows down processes of keratinization); it is necessary for growth of bones, normal reproductive function, embryonic development.

Pharmacokinetics. Ascorbic acid: absorption of ascorbic acid happens in a small bowel. Level of absorption reaches 50-70%. Absorption decreases at the use of fresh fruit and vegetable juice, alkaline drink. Easily gets into leukocytes, thrombocytes, and then into all fabrics. It is metabolized preferential in a liver. Not changed acid and metabolites are emitted with urine, and also with a stake and then. At use of high doses when concentration in plasma reaches more than 1,4 mg/dl, removal sharply amplifies.

Tocopherol: at intake about 50% of the accepted drug dose are slowly soaked up, the maximum level in blood is created in 4 h. Absorption requires availability of bile acids. It is deposited in adrenal glands, a hypophysis, seed plants, fatty and muscular tissue, erythrocytes, a liver. Is exposed to metabolism and it is allocated from an organism (in an invariable look and in the form of metabolites) with bile (over 90%) and urine (about 6%).

Retinolum: at intake Retinolum is soaked up almost completely, even at excess introduction it no more than 10% of the entered quantity are allocated with a stake. In the course of metabolism retinyl palmitate, Retinolum, a retinal and retinoic acid are formed. It is distributed in an organism unevenly: the greatest number is in a liver and a retina, smaller — in kidneys, heart, fat depos, lungs, the lactating mammary gland, in adrenal glands, etc. hemadens. A preferential form of deposition is ретинолпальмитат. Retinolum, a retinal, retinoic acid are emitted with hepatocytes as a part of bile, ретиноилглюкуронид is emitted with urine. Elimination of fat-soluble vitamins (tocopherol and Retinolum) is carried out slowly therefore repeated receptions lead to cumulation.

Indications to use:

It is applied at adults: for prevention of the damaging action on an organism and treatments of complications at the surgical, combined and symptomatic treatment of oncological patients, for the purpose of decrease in toxicity and increase in efficiency of chemotherapy and radiation therapy of tumors.

Route of administration and doses:

1 dose of a complex of vitamins for adults makes:

- ascorbic acid – 1 package of powder for preparation of solution for intake (1,0 g)

- acetate alpha tocopherol – 3 capsules (0,3 g)

- acetate Retinolum – 3 capsules (99000 ME)

The complex of vitamins should be applied on 1 dose once a day. All components which are a part of an antioxidant complex accept at the same time. Before use contents of a package of powder of ascorbic acid for preparation of solution for intake, are dissolved in 100 ml (1/2 glasses) of boiled water.

For prevention of development of postoperative complications in oncological patients – on 1 dose daily within 5-7 days before operation.

For decrease in toxicity beam or chemotherapy and increase in efficiency of treatment of tumors – on 1 dose daily throughout all course beam or chemotherapy.

Features of use:

High doses of ascorbic acid strengthen excretion of oxalates, promoting formation of stones in kidneys. At newborns whose mothers accepted high doses of ascorbic acid and at adults who accepted high doses, the "ricochet" scurvy can be observed. In connection with a promoting effect of ascorbic acid on synthesis of corticosteroid hormones it is necessary to monitor function of adrenal glands and arterial pressure. At prolonged use of high doses oppression of function of the insulyarny device of a pancreas therefore in the course of its treatment it is regularly necessary to control is possible. At patients with the increased maintenance of Fe in an organism it is necessary to apply ascorbic acid in the minimum doses. Intensive consumption of chewable tablets or a rassasyvaniye of peroral forms can cause damage of an adamantine substance of tooth. Ascorbic acid as a reducer can distort results of various laboratory tests (content in blood and wet glucose, bilirubin, activity of "hepatic" transaminases and LDG).

The diet with the increased content of selenium and sulfur-containing amino acids reduces the need for vitamin E. Now efficiency of use of vitamin E is considered unreasonable at treatment and prevention of the following diseases: beta talassemias, oncological diseases, a fibrozo-cystous dysplasia of a mammary gland, inflammatory diseases of skin, a hair loss, a usual abortion, heart diseases, the "alternating" lameness, a postmenopauzny syndrome, infertility, a round ulcer, a sickemia, burns, a porphyria, disturbances of nervomyshechny conductivity, thrombophlebitises, impotence, stings of bees, senile лентиго, a bursitis, a diaper dermatitis, pulmonary intoxication at pollution of the atmosphere, atherosclerosis, aging. Unproven consider use of vitamin E for increase in sexual activity.

Retinolum acetate (vitamin A) gets through a placenta in insignificant quantities. However it must be kept in mind that at exceeding of the recommended doses, the fruit can have malformations of an urinary system, a pre-natal arrest of development, early closing of epiphyseal regions of growth. In order to avoid risk of fetotokichesky effects pregnant women and nursing mothers should not accept an antioxidant complex.

Side effects:

At long reception of an antioxidant complex are possible: allergic reactions (skin rash, dermahemia), arterial hypertension, myocardium dystrophy, erythrocytopenia, thrombocytosis, thrombogenesis, neutrophylic leukocytosis, hypopotassemia, creatinuria, dispeptic frustration, signs of a hypervitaminosis of A, E, C, headache, dizziness, feeling of fatigue, slackness, fever, drowsiness, disorders of gait.

At drug withdrawal by-effects pass independently.

Interaction with other medicines:

Ascorbic acid: in combination with salicylates increases their concentration in serum and increases risk of a crystalluria. Increases level in blood of benzylpenicillin and tetracyclines. Reduces anticoagulating effect of derivatives of coumarin. Improves absorption in intestines of iron preparations, reduces - oral anticoagulants. Drugs of a quinolinic row, Calcii chloridum, salicylates, corticosteroids at prolonged use exhaust vitamin C reserves.

Tocopherol: strengthens effect steroid and non-steroidal anti-inflammatory drugs, cardiac glycosides, reduces toxicity of the last, and also vitamins A and D.

Retinolum: also the peroral kontratseptivna containing them are oestrogenic strengthen Retinolum absorption that can lead to development of the A-hypervitaminosis. During long therapy tetracyclines do not recommend to appoint vitamin A (the risk of development of intracranial hypertensia increases). Retinolum should be accepted in 1 hour prior to or in 4-6 hours after reception of a holestiramin. Absorption of Retinolum is broken by nitrites. Reduces (mutually) danger of a hypervitaminosis of D. Corticosteroids and alcohol intake reduce therapeutic effect.

Contraindications:

Contraindications are: hypersensitivity, thrombophlebitis, tendency to fibrinferments, a diabetes mellitus, a cardiosclerosis, a myocardial infarction, cholelithiasis, a nephrolithiasis, chronic pancreatitis, children's age, pregnancy, a lactation (it is necessary to stop breastfeeding).

With care apply at acute and chronic nephrite, heart failure of the II-III Art., the increased risk of development of thromboembolisms, at quickly proliferating and intensively metastasizing tumors.

Issue conditions:

According to the recipe

Packaging:

10 packages (unary) or 5 packages of 1000 mg doubled with powder of ascorbic acid, on three blister strip packagings with capsules of alpha tocopherol of acetate of 100 mg and capsules of Retinolum of acetate 33000 ME in packaging.