Neyrobion

General characteristics. Structure:

Active agents:

Thiamin hydrochloride (B1 vitamin)          of 100 mg
Pyridoxine hydrochloride (B6 vitamin)  of 100 mg
Cyanocobalamine (B12 vitamin)                 of 1 mg
 
Excipients: potassium cyanide, benzyl alcohol, hydroxide sodium solution, water for injections.

Description

Transparent solution of red color.

Pharmacological properties:

Drug contains a combination of vitamins of group B: thiamin (B1), pyridoxine (B6) and cyanocobalamine (B12). They play a special role as coenzymes in the intermediate metabolism proceeding in the central and peripheral nervous system. A special role in metabolic processes of a nervous system is played by the combined effect of B1, B6 and B12 vitamins that proves from combined use. The combined use of vitamins of group B is accelerated by processes of regeneration of the damaged nerve fibrils. It is proved that efficiency of a combination surpasses efficiency of a separate component. Like other vitamins, they are irreplaceable nutrients which cannot directly be synthesized in an organism.

Therapeutic use of these vitamins at various diseases of a nervous system is directed to, on the one hand, to compensate the existing insufficiency (perhaps because of the increased requirement of an organism caused directly by a disease) and, on the other hand, to stimulate natural mechanisms of recovery of function of nervous tissues. The analgeziruyushchy action of a complex of vitamins of group B exerting beneficial effect on therapeutic result is also proved.

Indications to use:

In complex therapy of diseases of a nervous system of various origin:
- epileptiform neuralgia
- paresis of a facial nerve
- the pain syndrome caused by backbone diseases (intercostal neuralgia; lumbar syndrome; cervical syndrome, syndrome shoulder brush; the radicular syndrome caused by degenerative changes of a backbone) - a lumbago, a sciatica
- the surrounding herpes.

Route of administration and doses:

The drug is administered intramusculary (deep injections in a gluteus).

In cases of the expressed pain syndrome it is reasonable to begin treatment with intramuscular introduction of 1 ampoule (3 ml) in days before removal of acute symptoms.
After improvement of symptoms or in cases of moderate weight: one ampoule 2-3 times a week within 2-3 weeks.

For a maintenance therapy, for prevention of the recurrence, or continuation treated drug Neyrobion in other dosage form is recommended (tablets coated).

Features of use:

The drug should not be administered intravenously.

Other vitamins, especially cyanocobalamine, can inaktivnrovatsya in the presence of B1 vitamin degradation products.

The clinical picture, and also laboratory analyses at a funicular myelosis or pernicious anemia can lose the specificity at administration of B12 vitamin.

Side effects:

In some cases at parenteral administration of Bi vitamin perspiration, tachycardia and allergic reactions in the form of a skin itch and rash are observed. In rare instances there can be hypersensitivity reaction: a dieback, the complicated breath, an acute anaphylaxis (after parenteral administration of B1 vitamin).

In some cases at administration of B12 vitamin (generally at intravenous infusions) the acne, eczema and urticaria were observed.

Interaction with other medicines:

At simultaneous use with a levodopa B6 vitamin can reduce protivoparkinsonichesky action of a levodopa.
Increase in need for B6 vitamin can arise at co-administration of D-penitsilamina and Cycloserinum.
It is not recommended to mix drug with other medicines in one syringe.
B1 vitamin collapses at interaction with the solutions containing sulfites.

Contraindications:

Hypersensitivity to any component of medicine. Children's age.

Use during pregnancy and a lactation

It is not recommended to apply.

Overdose:

B1, B6 and B12 vitamins have broad therapeutic range. Symptoms of overdose are not observed at use of drug in the recommended doses and the mode.
At intravenous administration of high doses of vitamins B a current of a long time (more than 2 months) intoxication symptoms can be observed.

B1 vitamin, the following symptoms after introduction of the dose exceeding recommended more than by 100 times are reported: headache, spasm of muscles, muscular weakness, paralysis, arrhythmia, allergic reactions.

B6 vitamin. neuropathy with an ataxy, disorders of sensitivity, epileptiform attacks with changes on EEG. After introduction more than 2 g a day were described cases of hypochromia anemia and seborrheal dermatitis.

B12 vitamin, after parenteral administration of a high dose allergic reactions, eczematic skin disturbances and a high-quality form of an acne were observed. In case of symptoms of overdose treatment by drug should be cancelled. If necessary symptomatic therapy, including, дес ен Sibi l iziruyushchy is appointed.

Storage conditions:

At a temperature not above 20 °C in the place protected from light. To store in the place, unavailable to children. Period of validity 3 years. Not to apply after expiry date.

Issue conditions:

According to the recipe

Packaging:

Solution for intramuscular introduction.
On 3 ml in an ampoule from dark glass like I. The point of a break and the marking strip is applied on an ampoule.
On three ampoules in a blister strip packaging together with the application instruction place in a cardboard pack.