DEXAMETHASONE - BIOFARM
Producer: CIAO Biofarm Ukraine
Code of automatic telephone exchange: S01B A01
Release form: Liquid dosage forms. Drops are eye.
General characteristics. Structure:
Active ingredients: 1 ml of drug contains phosphate sodium dexamethasone (dexamethasone of phosphate of disodium salt) – 1 mg;
excipients: boric acid, sodium pyroborate, dinatrium эдетат (Trilonum of B), a benzalkoniya chloride, water for injections.
Pharmacological properties:
Pharmacodynamics. Shows the expressed antiinflammatory and antiallergic action caused by release oppression by eosinophils of mediators of an inflammation; induction of formation of lipokortin and reduction of quantity of mast cells which develop a histamine and hyaluronic acid, with reduction of permeability of capillaries; stabilization of cellular membranes (in particular lizosomalny) and membranes of organellas.
Pharmacokinetics. At instillations in an eye dexamethasone is soaked up through a cornea with an intact epithelium in moisture of an anterior chamber. At an inflammation of tissues of eye or injury of a mucous membrane and a cornea the speed of absorption of dexamethasone increases.
Indications to use:
Not purulent allergic conjunctivitis, blefarokonjyunktivit, a keratitis, a keratoconjunctivitis without damage of an epithelium, an iritis, an iridocyclitis, an episcleritis, a sclerite, inflammatory processes after injuries of an eye and surgical intervention.
Route of administration and doses:
To adults and children 12 years drug are more senior dig in 1 – 2 drop in a conjunctival sac: at acute diseases – 4 – 5 times a day (during 2 - days), then – 3 – 4 times a day (within 4 – 6 days); at a chronic inflammation – 2 times a day (the course of treatment should not exceed 4 weeks); after injuries and ophthalmologic operations (since 8th day) – 2 – 4 times a day (within 2 – 4 weeks).
To children at the age of 6 – 12 years drug is dug in on 1 drop by 2 – 3 times a day within 7 – 10 days.
Features of use:
During treatment it is necessary to control the intraocular pressure and a condition of a cornea. At increase in intraocular pressure drug should be cancelled. The patients using contact lenses should remove them before administration of drug and to put on in 20 - 25 minutes after administration of drug.
Ability to influence speed of response at control of motor transport or other mechanisms. It was not investigated.
Side effects:
Burning sensations, insignificant hyperemia of a conjunctiva, dacryagogue which disappear in 5 – 15 seconds after a drug instillation are possible. At long use of drug increase in intraocular pressure, in case of thinning of a cornea - its perforation is possible.
Interaction with other medicines:
At long use along with yodoksuridiny strengthening of destructive processes in a cornea epithelium is possible. Drug can be used along with antibiotics, vitamins, observing a break between instillations of drugs not less, than 25 - 30 minutes.
Contraindications:
Viral and fungus diseases of eyes, acute forms of purulent infections in the absence of special therapy; cornea diseases which are followed by defects of an epithelium; eye hypertensia, trachoma, glaucoma; the increased individual sensitivity to drug components.
Overdose:
Considering a way of introduction, the overdose is improbable. Nevertheless, in case of overdose, excess of drug needs to be removed with flowing water.
Storage conditions:
In the cool, protected from light place at a temperature from 8 °C up to 15 to °s.khranit in the place, unavailable to children.
Issue conditions:
According to the recipe
Packaging:
On 10 ml in glass bottles; on one bottle with one cover dropper in a pack.