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medicalmeds.eu Medicines Proofreaders of disturbances of cerebral circulation. Vinpocetine таб 0,005 g No. 50

Vinpocetine таб 0,005 g No. 50

Препарат Винпоцетин таб 0,005 г №50. ЗАО "Северная Звезда" Россия



General characteristics. Structure:

Active agent: Vinpocetine of 5 mg

excipients (sugar milk, potato starch, talc, magnesium stearate, cellulose microcrystallic, gelatin medical);

Description: Tablets of color, white or white with a yellowish shade, a ploskotsilindriche-sky form with a facet and risky. Pharmakoterapevtichesky group: tserebrovazodilatiruyushchy means.




Pharmacological properties:

Possesses vasodilating, anti-hypoxemic and anti-aggregation action. Inhibits phosphodiesterase and increases the content of cyclic adenosinemonophosphate in cells that, in turn, leads to decrease in content of calcium in cytoplasm of smooth muscle cells and to relaxation of myofibrils. Combines vascular and metabolic actions.

Expands brain vessels, strengthens a blood stream, it is preferential in ischemic areas, improves supply of a brain with oxygen. Promotes utilization of glucose and increases the level of catecholamines in the central nervous system, stimulates metabolism of noradrenaline and serotonin in brain tissues.
Reduces aggregation of thrombocytes, viscosity of blood, promotes increase in deformability of erythrocytes and normalization of venous outflow against the background of decrease in resistance of brain vessels. System arterial pressure slightly goes down.

It is effective in the acute period of a stroke: accelerates regress of all-brain and focal neurologic symptomatology, improves memory, attention, intellectual productivity. Sensitivity of brain vessels to the running-down action of a Vinpocetine increases in advanced and senile age that is caused by a sensitization of system of adenylatecyclase – cyclic adenosinemonophosphate when aging. Bioavailability about 60% is quickly soaked up from digestive tract. The maximum concentration in a blood plasma is reached in 1 hour. Easily diffuses through gistogematichesky barriers (including through a blood-brain barrier) and gets into fabrics. Elimination half-life about 5 hours.


Indications to use:

Acute (after the termination of a course of parenteral administration of a Vinpocetine, and also in cases when parenteral administration is not shown or it is impossible) and chronic forms of insufficiency of cerebral circulation (including acute and residual stages of a stroke, the tranzitorny ischemic attacks, encephalopathies, multiinfarctive dementia). Vascular diseases of a retina and/or a choroid of an eye (owing to atherosclerosis, a vasomotor spasm, thrombosis); the degenerative changes of a macula lutea caused by atherosclerosis or a vasomotor spasm; secondary glaucoma (owing to obturation of vessels). Age vascular or toxic (medicamentous) hearing disorder, Menyer's disease, dizzinesses of a labyrinth origin. Vegetative manifestations of a menopausal syndrome.


Route of administration and doses:

Inside on 5 mg (1 таб) 3 times a day within 2 months. Before drug withdrawal it is necessary to reduce a dosage gradually. Repeated courses 2-3 times a year are possible.



Side effects:

Lowering of arterial pressure, tachycardia, premature ventricular contraction, delay of vnutrizhelu-dochkovy conductivity;



Contraindications:

Hypersensitivity, the expressed disturbances of a heart rhythm, coronary heart disease (heavy current), acute stage of a hemorrhagic stroke, pregnancy, the lactation period.


Overdose:

At intoxication the gastric lavage, reception of absorbent carbon and a symptomatic treatment are recommended. Interaction with other medicines Increases risk of hemorrhagic complications against the background of a geparinoterapiya.


Storage conditions:

List B. In dry protected from light and the place, unavailable to children, at a temperature not above 25 °C. Period of validity 2 years. Not to use after the date specified on packaging.


Issue conditions:

According to the recipe


Packaging:

Tablets on 5 mg On 10 tablets in a blister strip packaging, on 2, 3 or 5 blister strip packagings in a pack cardboard.



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