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medicalmeds.eu Medicines Tserebrovazodilatiruyushchy means Винпоцетин-САР®

Винпоцетин-САР®

Препарат Винпоцетин-САР®. ОАО "Биохимик" Республика Мордовия



General characteristics. Structure:

Active ingredient: 5 mg of a Vinpocetine.

Vspomogatelnyy substances: lactose, potato starch, magnesium stearate, cellulose microcrystallic, klutset, примогель.

Drug which possesses vasodilating, anti-hypoxemic and anti-aggregation action.




Pharmacological properties:

Pharmacodynamics. Possesses vasodilating, anti-hypoxemic and anti-aggregation action. Inhibits phosphodiesterase and increases the content of cyclic adenosinemonophosphate in cells that, in turn, leads to decrease in content of calcium in cytoplasm of smooth muscle cells and to relaxation of myofibrils. Combines vascular and metabolic actions.

Expands brain vessels, strengthens a blood stream, it is preferential in ischemic areas, improves supply of a brain with oxygen. Promotes utilization of glucose and increases the level of catecholamines in the central nervous system, stimulates metabolism of noradrenaline and serotonin in brain tissues. Reduces aggregation of thrombocytes, viscosity of blood, promotes increase in deformability of erythrocytes and normalization of venous outflow against the background of decrease in resistance of brain vessels.

System arterial pressure slightly goes down. It is effective in the acute period of a stroke: accelerates regress of all-brain and focal neurologic symptomatology, improves memory, attention, intellectual productivity. Sensitivity of brain vessels to the running-down action of a Vinpocetine on their smooth muscles increases in advanced age that is caused by a sensitization of system of adenylatecyclase – cyclic adenosinemonophosphate when aging

Pharmacokinetics. It is quickly soaked up from zheludochno – an intestinal path, bioavailability about 60%. The maximum concentration in a blood plasma is reached in 1 hour. Easily diffuses through gistogematichesky barriers (including through a blood-brain barrier) and gets into fabrics. Elimination half-life about 5 hours. It Biotransformirutsya in a liver, it is removed with a fecal masses


Indications to use:

Acute and chronic forms of insufficiency of cerebral circulation (including, acute and residual stages of a stroke, tranzitorny ischemic attacks, encephalopathies, multiinfarctive dementia).

Vascular diseases of a retina and/or choroid of an eye (owing to arteriosclerosis, a vasomotor spasm, thrombosis); the degenerative changes of a macula lutea caused by atherosclerosis or a vasomotor spasm; secondary glaucoma (owing to obturation of vessels).

Age vascular or toxic (medicamentous) hearing disorder, Menyer's disease, dizzinesses of a labyrinth origin. Vegetative manifestations of a menopausal syndrome


Route of administration and doses:

Inside on 5 mg (1 таб.) 3 times a day within 2 months. Before drug withdrawal it is necessary to reduce a dosage gradually. Repeated courses 2-3 times a year are possible.





Contraindications:

Hypersensitivity, the expressed disturbances of a heart rhythm, heavy coronary heart disease.

With care appoint at a hemorrhagic stroke (only after end of an acute stage), pregnancy, a lactation.



Storage conditions:

List B. In the dry, protected from light place at a temperature not above 25 °C. In the place, unavailable to children. A period of validity - 2 years. Not to use after the expiry date specified on packaging


Issue conditions:

According to the recipe


Packaging:

Tablets on 5 mg. On 10 tablets in a blister strip packaging. 2, 3, 5 blister strip packagings with the instruction to use in a cardboard box



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