Dramina

General characteristics. Structure:

Active ingredient: 50 mg dimenhydrinatum.

Excipients: lactoses monohydrate, cellulose microcrystallic, magnesium stearate, povidone, кросповидон.

Pharmacological properties:

Pharmacodynamics. Blocks histamine H1 receptors and M-holinoretseptory the central nervous system. The vestibular mechanism of an inner ear oppresses, affecting first of all otoliths, in high doses – semicircular canals. Renders antiemetic, anorexigenic, sedative, moderate antiallergic action, eliminates dizziness.

Pharmacokinetics. After intake drug is well soaked up, distributed on bodies and fabrics. Effect of drug is shown in 15-30 minutes and remains within 3-6 hours. It is almost completely brought out of an organism with urine during 24 h. Small quantities are removed with breast milk.

Indications to use:

- sea and aeroembolism;

- prevention and treatment of symptoms of vestibular and labyrinth disturbances (dizziness, nausea, vomiting), except for the symptoms caused by antineoplastic therapy;

- Menyer's disease.

Route of administration and doses:

Inside, before food:

- sea and aeroembolism: children from 3 to 6 years – 1/4 - 1/2 tablets 2-3 times a day; children from 7 to 12 years – 1/2 - 1 tablet 2-3 times a day; children are more senior than 12 years and adult – 1-2 tablets 2-3 times a day;

- prevention and treatment of symptoms of vestibular and labyrinth disturbances (dizziness, nausea, vomiting), except for the symptoms caused by antineoplastic therapy: children from 3 to 6 years – 1/4 - 1/2 tablets 2-3 times a day; children from 7 to 12 years – 1/2 - 1 tablet 2-3 times a day; children are more senior than 12 years and adult – 1-2 tablets 2-3 times a day;

- Menyer's disease: children up to 12 years – 1/2 - 1 tablet 2-3 times a day; children are more senior than 12 years and adult 1-2 tablets 2-3 times a day.

The maximum daily dose for adults should not exceed 7 tablets. For prevention of kinetoz it is necessary to take 1-2 pill in 30 minutes prior to a trip.

Duration of use of drug and possibility of repetition of a course of treatment – in coordination with the doctor.

Features of use:

Use at pregnancy and in the period of a lactation. Contraindicated (I trimester of pregnancy).

Perhaps with extra care (the II-III trimester) if the expected effect of therapy exceeds potential risk for a fruit.

For the period of treatment it is necessary to stop breastfeeding.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Considering side effects, it is necessary to be careful at occupations potentially dangerous types of activity requiring special attention and speed of psychomotor reactions (including control of motor transport).

Side effects:

From TsNS: dizziness, drowsiness, a headache, the general weakness, fatigue, disturbance of concentration of attention, concern, nervousness, sleeplessness, is rare – easing of night and color sight, a sight zatumanennost, accommodation disturbance.

From the alimentary system: dryness in a mouth, a loss of appetite, nausea, vomiting.

From respiratory system: xeromycteria and throats, condensation of a bronchial secret.

From cardiovascular system and blood: lowering of arterial pressure, tachycardia, hemolitic anemia.

Allergic reactions: skin rash, a Quincke's disease, a bronchospasm, it is rare - medicamentous dermatitis.

Others: difficulty of an urination.

It is necessary to notify the doctor on all cases of by-effects.

Interaction with other medicines:

Strengthens effects of atropine, tricyclic antidepressants, catecholamines, barbiturates, alcohol, sedative and hypnagogues, neuroleptics, weakens - corticosteroids, anticoagulants.

Lowers reaction to Apomorphinum.

Reduces depressive action of acetylcholine by a cardiac muscle.

The combination to bismuth drugs, Scopolaminum, anesthetics and psychotropic drugs increases probability of a vision disorder.

It is incompatible with ototoksichesky antibiotics (streptomycin, Neomycinum, Viomycinum, amikacin, Kanamycinum) since can mask symptoms of ototoxicity and promote development of an irreversible hearing disorder.

Contraindications:

Hypersensitivity to drug components, epilepsy, an acute exudative and vesicular dermatosis, children's age up to 3 years, pregnancy, the lactation period.

With care. A convulsive syndrome, closed-angle glaucoma, a prostate hyperplasia, bronchial asthma, cardiovascular diseases, a hyperthyroidism, the stenosing round ulcer, piloroduodenalny obstruction and obstruction of a neck of a bladder.

Overdose:

Overdose symptoms: dryness in a mouth, in a nose and a throat, the face reddening which is slowed down and the complicated breath, confusion of consciousness, children have spasms, hallucinations.

At emergence of the specified symptoms it is necessary to see a doctor urgently.

Treatment: a gastric lavage a suspension of absorbent carbon (20-30 g), purpose of salt laxative (10-15 g of sodium of sulfate), symptomatic therapy, at spasms at children – phenobarbital (5-6 mg/kg), diazepam.

Storage conditions:

At a temperature not above 25 °C, in the place, unavailable to children. A period of validity - 5 years. Not to apply after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets of 50 mg. On 5 or 10 tablets in PVC / It is scarlet the blister. One blister together with the application instruction is placed in a cardboard pack.