Lidocaine of Asept

General characteristics. Structure:

Active ingredients: 0,1 g of lidocaine of a hydrochloride, 0,0005 g of a hlorgeksidin of a biglyukonat in 1 ml of solution.

Excipients: alcohol, propylene glycol, menthol, sodium hydroxide, the water purified.

Pharmacological properties:

Pharmacodynamics. Lidokain-Asept spray for topical administration has locally anesthetizing and antiseptic effect and causes terminal anesthesia. Mestnoanesteziruyushchy effect of lidocaine of a hydrochloride is caused by oppression of nerve conduction due to blockade of natrium channels in nerve terminations.

Antiseptic action of a hlorgeksidin of a biglyukonat – it is active (бактерициден) concerning the majority of gram-positive and gram-negative aerobic bacteria, treponemas, gonokokk, trichomonads. Effect of drug is shown in 1 minute after drawing on mucous membranes or skin and remains for 5-15 minutes; the mestnoanesteziruyushchy effect and subjective feeling of numbness stop gradually approximately in 15-20 minutes.

Pharmacokinetics. At topical administration on mucous membranes extent of absorption of lidocaine of a hydrochloride is various and depends on a dose, the place of use and blood supply of a mucous membrane.

After putting drug on a mucous membrane of upper respiratory tracts, a part of drug it is swallowed with the subsequent inactivation in digestive tract. Considerably the smaller amount of lidocaine gets through mucous into a system blood stream. The maximum concentration in a blood plasma is reached in 10-20 min.

Lidocaine is metabolized in a liver with formation of two pharmacological active metabolites. It is removed with urine in the form of metabolites.

Hlorgeksidin биглюконат – at topical administration is practically not soaked up as it is used in the minimum therapeutic concentration, its system influence is minimum.

Indications to use:

Drug can be used for a local anesthesia and disinfecting in the following cases:
- in stomatology for a local anesthesia and disinfecting of a point of a prick before local anesthesia;
- in case of opening of superficial abscesses, removal of the shaking milk teeth and splinters of bones;
- at suture on a mucous membrane;
- when fixing crowns and bridges;
- at treatment of an inflammation of gums, periodontopathies;
- during removal of a dental calculus;
- at an extirpation of the increased interdental nipple;
- at production of prints of dentition only in case of use of elastic material;
- at radiological survey, for elimination of nausea and a gag reflex;
- in otorhinolaryngology when carrying out coagulation by means of an electrocauter at treatment of nasal bleedings;
- at operations on a nasal partition and removal of polyps of a nose, and also for the purpose of elimination of a gag reflex and anesthesia and disinfecting of an injection site of a syringe needle before removal of almonds;
- when opening peritonsillar abscesses and before a puncture of a Highmore's bosom (only for additional anesthesia);
- for anesthesia of a Highmore's bosom, mucous before washing.
- at use of drug before throat or nasopharynx operation it is necessary to consider that as a result of full elimination of a gag reflex drug, getting into a throat and a trachea interferes with a tussive reflex and can cause bronchial pneumonia. Thereof during removal of almonds and at an adenotomy it is not recommended to use drug for a local anesthesia at children up to 8 years because of the speeded-up swallowing reflex.
- at tool and endoscopic inspections before introduction of the probe through a mouth or a nose (duodenal sounding and a fractional research of gastric secretion), at a rektoskopiya, an intratracheal anesthesia, after performing tracheotomy and in case of change of a cannula;
- in obstetrics and gynecology for anesthesia of a crotch during an epiziotomiya and processing of a section;
- during removal of seams;
- for anesthesia and disinfection of a surgery field at small vagina or neck of uterus operations;
- when processing nitevy suppuration;
- for anesthesia and disinfecting at small surgical interventions on integuments.

Route of administration and doses:

Drug is used locally. Before use by means of a special nozzle or the raspylitelny pump irrigate the place of use. To remove a safety cap from the pump and to put on a rod of the valve special on a cage. To direct the free end of a nozzle to the place of irrigation and to press a head. After use to wash out a nozzle alcohol or the distilled water.

The dose of drug can widely vary depending on the size and character of the processed surface. In order to avoid absorption of drug in a system blood stream to a trace ет to try on the minimum dose providing sufficient effect. There is usually enough 1-3 doses. One dose contains 0,1-0,14 ml of drug which contains 10-14 mg of lidocaine of a hydrochloride. In gynecologic practice in some cases – till 5-10 doses. 20 doses are as much as possible allowed. To children is more senior than 2 years – 1-2 doses. By preliminary impregnation of a cotton plug drug can be used for greasing.

Dosage for children: Lidokain-Asept at children in dental practice it is more preferable to apply spray to topical administration in the form of greasing. In such a way use can be avoided исп the patient's uga when spraying drug when using it at children is younger than 2 years.

Features of use:

It is necessary to watch that drug did not get into airways (danger of aspiration). Use of drug in a drink demands the increased care. Treatment of the weakened and elderly people should be carried out by small doses taking into account their age and the general state.

At pregnancy use of drug in a therapeutic dose does not constitute danger to mother. Lidocaine a hydrochloride gets into maternal milk. Therefore during pregnancy and a lactation the trace ut drug to appoint only according to strict indications.

Side effects:

At the time of putting spray weak burning which stops after anesthesia approach can be felt (within 1 min.). There can seldom be allergic reactions (skin rash, an itch, an acute anaphylaxis). Extremely seldom side reactions from the central nervous system can be observed: headache, dizziness, concerns, vision disorder, depression; from cardiovascular system: arterial hypertension, bradycardia, spasms, tremor, etc.

Interaction with other medicines:

Drug should be used carefully at patients who accept adrenoblockers (strengthening of antiarrhythmic action), blockers of neuromuscular transfer (possible strengthening of action of the last), sedative drugs (strengthening of sedation), procaineamide (hallucinations), Phenytoinum (at its intravenous administration oppression of antrioventrikulyarny conductivity is possible).

Under the influence of monoamine oxidase inhibitors strengthening of mestnoanesteziruyushchy effect of lidocaine is probable.

Contraindications:

- hypersensitivity to lidocaine to a hydrochloride, a hlorgeksidina to a biglyukonat or other components of drug;
- a sick sinus syndrome at patients of advanced age;
- an atrioventricular block of II and III degrees (except for cases when the probe for stimulation of ventricles is entered);
- cardiogenic shock;
- the expressed abnormal liver functions;
- heavy myasthenia;
- existence in the anamnesis of epileptiform spasms.

Overdose:

At overdose there can be reactions from cardiovascular system and the central nervous sista we: nausea, vomiting, pallor of integuments, psychomotor excitement, tremor, kloniko-tonic spasms, collapse, oppression of the central nervous system.

Treatment: for removal of possible spasms it is necessary to enter 50-100 mg of a suktsinilkholin and/or 5-15 mg of diazepam. It is also possible to apply barbiturates of short-term action, for example, sodium thiopental.

In the presence of reaction from cordial vascular system (bradycardia, disturbance проводимос ти) atropine use (0,5-1 mg intravenously) and sympathomimetic means is reasonable.

Respiratory tracts have to be free, in need of the patient intubate, carry out artificial ventilation of the lungs with oxygen and other resuscitation actions.

Storage conditions:

List B. At the room temperature in the place protected from light. Drug should be stored in the places unavailable to children. A drug period of validity – 2 years. After a period of validity drug should not be used.

Issue conditions:

According to the recipe

Packaging:

Produce in bottles 25 ml, 50 ml, 70 ml, 100 ml of the solution containing 10% of lidocaine of a hydrochloride and 0,05% of a hlorgeksidin of a biglyukonat.

Packaging: the bottle with a special nozzle with the screwed cap or supplied with the raspylitelny pump and protection with a ny cap and the application instruction is placed in a pack from a cardboard. EAN-13 code: 460700695 077 1, 460700695 078 8, 460700695 079 5, 460700695 080 1 respectively for a fl of games of 25, 50, 70 and 100 ml.