Gingium

General characteristics. Structure:

Active ingredient: the dry standardized extract of leaves of a ginkgo of a bilob that corresponds to 17.6-21.6 mg of gingoflavonoglikozid and 4-5.6 mg of terpenlakton.

Pharmacological properties:

Gingium — drug of a plant origin, normalizes a metabolism in cells, rheological properties of blood and microcirculation. Improves cerebral circulation and providing a brain with oxygen and glucose, interferes with aggregation of erythrocytes, brakes a factor of activation of thrombocytes. Exerts the dozozavisimy regulating impact on vascular system, stimulates development of an endoteliystabiliziruyushchy factor, expands small arteries, raises a tone of veins, thereby regulates a krovenapolneniye of vessels. Reduces permeability of a vascular wall (antiedematous effect — both the central, and peripheral action). Has antitrombotichesky effect (due to stabilization of membranes of thrombocytes and erythrocytes, influence on synthesis of prostaglandins, decrease in effect of biologically active agents and a platelet activating factor). Education of free radicals is interfered also by the FLOOR of cellular membranes. Normalizes release, the return capture and a catabolism of neurotransmitters (Norepinephrinum, dopamine, acetylcholine) and their ability to contact receptors. Has anti-hypoxemic effect, improves a metabolism in bodies and fabrics, promotes accumulation in cells of makroerg, increase in utilization of oxygen and glucose, normalization of mediator processes in TsNS.

After intake of a dose of 80 mg of extract of a ginkgo of a bilob absolute bioavailability is established: 98% — for a ginkgolid And, 79% — for a ginkgolid In and 72% — for a bilobalid.

Cmax in a blood plasma — 15 ng/ml for a ginkgolid And, 4 ng/ml — for a ginkgolid In and ≅12 ng/ml — for a bilobalid.

Linkng with proteins of a blood plasma — 43% for a ginkgolid And, 47% — for a ginkgolid In and 72% — for a bilobalid.

With use it 14C-is radioactive marked extract of a ginkgo of a bilob established that Cmax in a blood plasma is reached in 1,5 h, T½ is 4,5 h.

Indications to use:

Cognitive disorders of various genesis (distsirkulyatorny encephalopathy owing to a stroke, craniocereberal injuries, at senile age that is shown by disorders of attention and/or memory, decrease in mental abilities, sensation of fear, a sleep disorder) and neurosensory disturbances of various genesis (a senile degeneration of a macula lutea, a diabetic retinopathy); the alternating lameness at chronic obliterating arteriopatiya of the lower extremities (the II degree according to Fontaine); vision disorder of vascular genesis, decrease in its sharpness; a hearing disorder, a ring in ears, dizziness and an incoordination of preferential vascular genesis; Reynaud's syndrome.

Route of administration and doses:

Cognitive frustration: on 1 tablet of 80 mg 2–3 times a day or on 1 tablet of 120 mg 1–2 times a day. Duration of treatment has to make not less than 8 weeks. In 3 months of therapy the doctor has to check need of further use of drug.

Peripheral occlusal diseases of arteries, and also dizziness of a vascular and involutional origin: on 1 tablet of 80 mg 2 times a day or on 1 tablet of 120 mg of 1 times a day. Duration of treatment makes not less than 8 weeks.

At dizziness duration of therapy makes no more than 6-8 weeks.

Duration of treatment of a sonitus — not less than 12 weeks.

To swallow of tablets without chewing, washing down with enough liquid (1 glass of water). A pill is taken irrespective of meal.

Features of use:

At patholologically the increased tendency to bleedings (hemorrhagic diathesis), and also at simultaneous use of anticoagulants it is necessary to accept drug only after consultation with the doctor.

Content of extract of a ginkgo of a bilob increases tendency to bleedings, administration of drug needs to be stopped before surgeries.

Drug contains lactose therefore to patients with rare hereditary intolerance of a galactose, deficit of lactase or a sprue of glucose galactose administration of drug is contraindicated.

Use during pregnancy and feeding by a breast. Due to the lack of clinical data drug is not recommended to be used during pregnancy and feeding by a breast.

Ability to influence speed of response at control of vehicles or work with mechanisms. Before clarification of individual reaction to drug during treatment it is necessary to be careful during the driving and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Children. There is no sufficient experience of use of drug for treatment of children.

Side effects:

Seldom 

From a GIT: nausea, vomiting.

From a nervous system: headache, dizziness.

Allergic reactions of skin: reddening, hypostasis, itch, rash.

In rare instances at use of the drugs containing extract of a ginkgo of a bilob, especially at simultaneous use with anticoagulants (such as фенпрокумон, acetylsalicylic acid and other NPVP), there are hemorrhages (in a brain, gastrointestinal, in an eye).

Interaction with other medicines:

At simultaneous use with the medicines inhibiting blood coagulation (such as фенпрокумон, acetylsalicylic acid and other NPVP), the effect of the last can amplify.

Contraindications:

Hypersensitivity to any of auxiliary components of drug.

Overdose:

At overdose increase in expressiveness of side effects is possible. 

Treatment: symptomatic.

Storage conditions:

In original packaging, at a temperature not above 30 °C.

Issue conditions:

According to the recipe

Packaging:

Tablets п / captivity. cover of 80 mg blister, No. 30, No. 60, No. 120

Tablets п / captivity. cover of 120 mg blister, No. 30, No. 60, No. 120