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medicalmeds.eu Medicines Antiulcerous means, inhibitor of the protonew pump. Омегаст®

Омегаст®

Препарат Омегаст®. АО «Нобел Алматинская Фармацевтическая Фабрика» Республика Казахстан


Producer: JSC Nobel Almatinskaya Pharmatsevticheskaya Fabrika Republic of Kazakhstan

Code of automatic telephone exchange: A02BC01

Release form: Firm dosage forms. Capsules.

Indications to use: Peptic ulcer of a stomach. Peptic ulcer of 12 perstny guts. Reflux esophagitis. Zollingera-Ellison's syndrome. Erosive gastritis.


General characteristics. Structure:

Active ingredient: 20 mg of an omeprazol.

Excipients: sugar micropellets, Mannitolum, sodium lauryl sulfate, sodium glikolit starch type A (эксплотаб), the diacetylized monoglyceride (mivatst), a gipromelloza phthalate 50 (HP 50), povidone (PVP K 30), a gidroksipropilmetiltsellyuloz 603 (gipromelloza), sucrose, talc.

Structure of a cover: titanium E 171 dioxide, quinolinic yellow E 104, ferrous oxide red E 172, indigo carmine - FD&C blue 2 (E132), gelatin.




Pharmacological properties:

Pharmacodynamics. Omeprazol is inhibitor N +-To +-ATP-ases. Activity of N +-To +-brakes ATP-ases in covering cells of a stomach, thereby blocks a final stage of secretion of hydrochloric acid that leads to decrease in level of basal and stimulated secretion. After the reception termination secretory activity is completely recovered in 3-5 days.

Pharmacokinetics. At intake it is quickly soaked up from a GIT. Gets into covering cells of a mucous membrane of a stomach. For 90-95% contacts proteins of a blood plasma. It Biotransformirutsya in a liver. About 72-80% are removed by kidneys, 20% are removed with a stake. The elimination half-life makes 0,5 - 1 hour.

At patients with chronic diseases of a liver the elimination half-life increases till 3 o'clock. After a single dose of drug inside therapeutic action develops within the first hour, reaches a maximum in 2 h and continues during 24 h.


Indications to use:

- peptic ulcer of a stomach and duodenum;

- gastroesophageal reflux disease;

- Zollinger's syndrome - Ellisona;

- the digestive tract erosive cankers connected with reception of NPVS.


Route of administration and doses:

At a peptic ulcer of a stomach and duodenum and an ezofagealny reflux appoint on 1 capsule (20 mg) once a day. Duration of treatment is 4 weeks. At inefficiency of use of this dose of an omeprazol, and also antagonists of H2 receptors it is necessary to appoint 2 capsules (40 mg) once a day. At the prevailing most of patients improvement of a state is observed in 2 weeks. At Zollingera-Ellison's syndrome appoint 3 capsules once a day. Depending on a condition of the patient the dose can be increased to 180 mg. The day dose exceeding 80 mg should be accepted in 2 receptions.

Single dose - 20 mg, a daily dose - 20 mg; the maximum single dose - 40 mg, the maximum daily dose - 180 mg.


Features of use:

Before therapy omeprazoly it is necessary to exclude malignant new growths of digestive tract as treatment omeprazoly can disguise symptomatology. Against the background of an omeprazol distortion of results of laboratory indicators of a liver and indicators of gastrin in plasma is possible.

Pregnancy and lactation. It is not recommended to apply to pregnant women and nursing mothers as adequate researches were not conducted.

Features of influence of medicine on ability to manage the vehicle of Leah potentially dangerous mechanisms. It is necessary to be careful.


Side effects:

- nausea, obstipation, diarrhea, abdominal pains, meteorism;

- dizziness, headache, weakness;

- anemia, eosinopenia, thrombocytopenia, neutropenia;

- in some cases hamaturia, proteinuria;

- arthralgia, muscular weakness, mialgiya;

- in rare instances skin rash.


Interaction with other medicines:

pylori at simultaneous use of an omeprazol and antibiotics allows to stop to Eradikation N. quickly disease symptoms, to reach high extent of healing of the damaged mucous, permanent long remission and to reduce probability of development of bleeding from digestive tract.

Against the background of reception of an omeprazol decrease in absorption of a ketokonazol, delay of removal of diazepam, warfarin, Phenytoinum and other medicines which are metabolized in a liver with the participation of system P450 2C19 cytochrome is possible.

At prolonged use of an omeprazol and klaritromitsin there is an increase in their concentration in a blood plasma.

At simultaneous use with antacids medicinal interaction is not noted.


Contraindications:

- patients with hypersensitivity to drug;

- patients with chronic diseases of a liver;

- children's age up to 18 years;

- pregnancy;

- lactation.


Overdose:

Signs of overdose were noted after administration of drug in a dose from 320 mg to 900 mg (i.e. in doses, at 16-45 times exceeding therapeutic).

Symptoms: vision disorders, confusion of consciousness, sweating strengthening, drowsiness, dryness in a mouth, a headache, nausea, tachycardia, arrhythmia.

Treatment: carry out symptomatic therapy. Carrying out a hemodialysis is not rather effective in connection with high extent of linkng of an omeprazol with proteins of a blood plasma.


Storage conditions:

To store at a temperature not above 25 °C in the dry, protected from light place. To store in the place, unavailable to children! Period of storage 2 years. Not to apply after a period of validity.


Issue conditions:

According to the recipe


Packaging:

Capsules of 20 mg. On 7 or 10 capsules place in a blister strip packaging from a formatura of aluminum and printing aluminum foil.

On 1 (for 10 capsules) or 2 (for 7 capsules) planimetric packagings together with the instruction on a medical use in the state and Russian languages place in a pack cardboard with the hologram of firm - producer.



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