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medicalmeds.eu Medicines The means operating on a nervous system. Analgin-Darnitsa, solution for and 50% on 2 ml No. 10

Analgin-Darnitsa, solution for and 50% on 2 ml No. 10

Препарат Анальгин-Дарница, р-р д/и 50% по 2мл №10. ЗАО "Фармацевтическая фирма "Дарница" Украина


Producer: CJSC Pharmaceutical Firm Darnitsa Ukraine

Code of automatic telephone exchange: N02BB02

Release form: Liquid dosage forms. Solution for injections.

Indications to use: Hepatic colic. Renal colic. Hyper thermal syndrome (Fever). Miositis. Radiculitis. Neuralgia. Arthralgia. Headache. Pain syndrome. Burns. Dentagra. Dysmenorrhea.


General characteristics. Structure:

1 ml of solution contains metamizole sodium - 0,25 g or 0,5 g;
excipients: sodium sulfite, rongalite, acid solution hydrochloric 0,1M, water for injections.




Pharmacological properties:

Drug has the expressed analgesic and febrifugal effect. The Analgetichesky effect is connected with oppression of biosynthesis of the endogenous mediators of an inflammation involved in emergence of pain reaction (cytokines, bradykinins, some prostaglandin, etc.). Analgin-Darnitsa interferes with carrying out painful impulses nerve fibrils and raises an excitation threshold at the level of a thalamus. The mechanism of antipyretic action is caused by reduction of education and release of substances from neutrophilic leukocytes, endotoxins of bacteria, etc.

Pharmacokinetics. At intramuscular introduction it is quickly and completely soaked up in blood. In a liver is exposed to oxidizing deamination. Processes of deamination take place in children's age more slowly, than at adults. At frequent introduction (is more often than 4 times a day) at children cumulation of drug and intoxication is possible.
In blood after parenteral administration drug is found only in the form of metabolites. Metamizol and its metabolites very poorly contact proteins of plasma. They are quickly and evenly distributed in fabrics. The maximum concentration is reached in 1-1,5 hours after parenteral administration. The elimination half-life makes about 7 hours. Metabolites are completely removed with urine, 71% of the entered dose are found in the range from 0 till 24 o'clock, 18% - from 24 to 48 hours.


Indications to use:

Pain syndrome of various origin and localization (head, a dentagra, burns, pain in the postoperative period, a dysmenorrhea, arthralgias, neuralgia, radiculitises, miozita); feverish states (at flu, acute respiratory infections); renal and hepatic gripes (in a combination with antispasmodics).


Route of administration and doses:

The adult the drug is administered intramusculary or intravenously in case of severe pain on 1-2 ml of 25% or 50% of solution by 2-3 times a day, but totally it is no more than 2 g in days. Subcutaneous injections painful because metamizole sodium has local irritant action.
To children appoint as febrifugal and analgetichesky means in a single dose 0,1 - 0,2 ml of 50% of solution or 0,2 - 0,4 ml of 25% of solution for 10 kg of body weight.
If necessary the drug is administered repeatedly to 3 times a day.


Features of use:

Analgin-Darnitsa it is necessary to appoint with care. At emergence of fever, inflammatory processes in an oral cavity, a throat, a nose or deterioration in process of swallowing it is necessary to stop drug use. In need of long treatment it is necessary to carry out control of a picture of peripheral blood periodically.
Analgin-Darnits's use for pregnant women (especially in the I trimester and in the last 6 weeks) has to be limited in spite of the fact that teratogenic and embriotoksichesky effect of drug is not revealed.
In the period of a lactation drug is used with care.


Side effects:

Allergic reactions: a bronchospasm, skin rash, a Quincke's edema, it is rare - an acute anaphylaxis. At long use of drug hemopoiesis oppression (a granulocytopenia, an agranulocytosis) is possible.


Interaction with other medicines:

At simultaneous use with barbiturates a variable effect; perhaps both strengthening of action of Analgin-Darnits, and decrease it. The analgetic effect of Analgin-Darnits at simultaneous use with codeine amplifies. The probability of a leukopenia at simultaneous use of Analgin-Darnits and mercazolil amplifies. Analgin-Darnitsa strengthens effect of antidiabetic peroral drugs.


Contraindications:

The increased individual sensitivity to drug (it is shown in the form of skin reactions, a bronchospasm), an agranulocytosis, thrombocytopenia, a gepatoporfiriya, dekompensirovan-ny disturbances of functions of a liver or kidneys.



Storage conditions:

To store in protected from light and the place, unavailable to children. A period of validity - 2 years.


Issue conditions:

According to the recipe


Packaging:

On 1 ml and 2 ml in ampoules; 10 ampoules in cardboard packaging.



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