Cofalginum

General characteristics. Structure:

Main physical and chemical properties: tablets of a round form, white or yellow-white color, with slanted edges (with a facet) and risky; structure: 1 tablet contains metamizol of sodium salt – 300 mg, caffeine-sodium benzoate – 50 mg; excipients: potato starch, talc, stearic acid.

Pharmacological properties:

Pharmacodynamics. Cofalginum – the combined medicine which effect is caused by properties of the components which are its part.
Metamizole sodium – an analgetic antipyretic, derivative pyrazyl ketone, renders analgeziruyushchy, febrifugal and weak antiinflammatory action which mechanism is connected with oppression of synthesis of prostaglandins preferential in the central nervous system.
Caffeine – derivative methylxanthine, stimulates the psychomotor centers of a brain, has analeptical effect, strengthens effect of analginum, eliminates drowsiness and feeling of fatigue, increases physical and intellectual effeciency.

Pharmacokinetics. The components which are a part of drug undergo transformations inherent to them.
Analginum at oral administration quickly and almost is completely soaked up, reaching the maximum concentration in blood in 1–1,5 h. In the course of biotransformation it demetilirutsya and acetylated. Products of metabolism are removed with urine. The elimination half-life makes about 7 h. Linkng with blood proteins of 50-60%.
Caffeine-sodium benzoate is also well soaked up from a digestive tract. It is evenly distributed in an organism, easily gets through a blood-brain barrier. In the course of biotransformation a small part (about 8%) in not changed look demetilirutsya and oxidized, brought out of an organism with urine in the form of metabolites. In 24 h completely eliminirut. After reception of 100 mg caffeine-sodium benzoate time of semi-removal makes 3,9 – 5,3 h.

Indications to use:

Apply to removal of moderately expressed pain syndrome, at a headache, neuralgia, arthritises, miozita, rheumatism; as an antipyretic at fevers of a different origin.

Route of administration and doses:

Cofalginum is appointed the adult on 1 – 2 tablets 2 – 3 times a day. A pill is taken without chewing, washing down them with a small amount of water. The maximum single dose makes 1 g (3 tablets). The maximum daily dose – 3 g (10 tablets). However treatment duration in such dose should not exceed 1-2 days. Recommend to children from 3 to 14 years 1/2 tablets 3 – 4 strike in days. The daily dose for children up to 10 years – 2 tablets, up to 14 years – 4 tablets is maximum. Duration of treatment depends on efficiency of treatment and sensitivity to drug, is established individually.

Features of use:

Prolonged use is not recommended.
With care appoint drug to patients with bronchial asthma, persistent infections of respiratory tracts; at hypersensitivity to analgetics and non-steroidal anti-inflammatory drugs; to patients with allergic reactions (in connection with the increased danger of development of an acute anaphylaxis in this category of patients), alcoholism.
For the period of treatment stop feeding by a breast.
To children aged up to 14 years drug is appointed only under control of the doctor.
There are no messages on influence of drug on attention, ability to manage vehicles.

Side effects:

Allergic reactions (an acute anaphylaxis, skin rashes, rashes on mucous membranes, a small tortoiseshell); sleep disorders, tachycardia.
From system of a hemopoiesis: agranulocytosis, leukopenia, thrombocytopenia, hemolitic anemia.
From an urinary system: tranzitorny oliguria, anury, proteinuria; sometimes – intersticial nephrite. Coloring of urine in red color is possible.

Interaction with other medicines:

Strengthens effect of barbiturates, codeine, paracetamol, H2 blockers of histamine receptors, an anapralin. Sarcolysine and мерказолин increase probability of a leukopenia. Increases hypoglycemic activity of peroral antidiabetic means, sedative effect of alcohol, reduces concentration of cyclosporine in blood.

Contraindications:

Drug is contraindicated at an allergy to any of its components, arterial hypertension, glaucoma, a hyperexcitability, a sleep disorder, at the expressed abnormal liver function and kidneys, hemopoiesis oppression, during pregnancy and feeding by a breast. Children should not appoint drug up to 3 years.

Overdose:

At overdose there can be an excitement, dizziness, hurried breathing, vomiting, a shiver, spasms, consciousness disturbance, an agranulocytosis, a hemorrhagic syndrome.
Treatment: gastric lavage, artificial diuresis, purpose of enterosorbents, symptomatic therapy.

Storage conditions:

To store in dry, protected from light and the place, unavailable to children, at a temperature not above 25 °C.

Period of validity - 1 year.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in planimetric bezjyacheykovy packaging. On 10 tablets in a blister strip packaging, on 1 packaging in a pack.