Analginum of 50% solution

General characteristics. Structure:

Active agent: metamizole sodium of 500 mg 1000 mg.

Excipient: water for injections to 1 ml to 2 ml.

Pharmacological properties:

Pharmacokinetics. After intake metamizole sodium is quickly hydrolyzed in a gastric juice with formation of an active metabolite of 4-methyl-amino-antipyrine. After intramuscular introduction metamizole sodium is quickly distributed in bodies and fabrics with formation of a metabolite 4-formyl-amino-antipyrine and other metabolites.

After intravenous administration metamizole sodium quickly becomes unavailable to definition.

Metabolites of metamizole sodium do not contact proteins of a blood plasma. The greatest part of a dose is removed with urine in the form of metabolites. Metabolites are allocated with breast milk.

Pharmacodynamics. Analgetic antipyretic. Is derivative pyrazyl ketone. Possesses the expressed analgetic, antiinflammatory and febrifugal action which mechanism is connected with oppression of synthesis of prostaglandins.

Indications to use:

- pains of various origin (a headache, a dentagra, дисальгеменорея, neuralgia, radiculitises, mialgiya, renal and hepatic colic, injuries, burns, after operations;

- feverish states, flu, rheumatism, chorea.

Route of administration and doses:

Enter intramusculary or intravenously (at severe pains) the adult 1-2 ml of 50% of solution 2-3 times a day; no more than 2 g a day. To children appoint 50% of solution for 10 kg of body weight at the rate of 0,1-0,2 ml.

Subcutaneously do not enter as the irritation of fabrics is possible.

The maximum doses for adults: intramusculary and in intravenously – one-time 1 g, daily 2 g.

Drug is intended for short-term use.

Duration of treatment is determined by the attending physician.

Features of use:

With care to apply at children in the first 3 months of life.

At prolonged use it is necessary to control a pattern of peripheral blood.

At use of analginum coloring of urine in red color is possible. Metamizole sodium is applied in a combination with pitofenony and a fenpiveriniya bromide as analgetic means with spasmolytic action.

Considering side effects of medicine, it is necessary to be careful when driving or potentially dangerous mechanisms.

Side effects:

- nausea, vomiting, anorexia, pains in epigastric area, a meteorism, a lock, diarrhea;

- headache, dizziness, excitement, irritability.

Seldom:

- paresthesias, sonitus, vision disorder, tremor, depression;

- skin rash, a Quincke's edema, it is rare – an acute anaphylaxis.

At prolonged use:

- leukopenia, agranulocytosis, anemia, thrombocytopenia;

- infiltrates in an injection site (are possible at intramuscular introduction).

Interaction with other medicines:

Simultaneous use of analginum with other analgetics antipyretics, non-steroidal anti-inflammatory drugs can lead to mutual strengthening of toxic effects.

At simultaneous use with inductors of microsomal enzymes of a liver reduction of efficiency of metamizole sodium is possible.

At simultaneous use activity of indirect anticoagulants, peroral gipoklikemichesky drugs, glucocorticosteroids, indometacin owing to their replacement from communication with blood proteins under the influence of analginum amplifies.

At simultaneous use with proizvody the fenotiazina is possible the expressed hyperthermia; with sedatives, anxiolytics - analgeziruyushchy effect of analginum amplifies; with tricyclic antidepressants, oral contraceptives, Allopyrinolum - are broken metabolism of analginum and increase its toxicity; with caffeine – effect of analginum amplifies; with cyclosporine – concentration of cyclosporine in a blood plasma decreases.

At use of analginum in a combination from a pitofenon mutual strengthening of their pharmacological action happens a hydrochloride (has direct myotropic effect on smooth muscles of internals and causes its relaxation) and with a fenpiveriniya bromide (m – a holinoblokator) that is followed by reduction of a pain syndrome, relaxation of unstriated muscles and decrease in the increased body temperature.

Barbiturates, codeine, анаприлин, blockers of H2-histamine receptors strengthen effects of analginum; the last increases hypoglycemic effect of peroral antidiabetic drugs, and also sedative effect of alcohol.

Contraindications:

- the expressed disturbances of functions of a liver and kidneys;

- deficit glyukozo-6-fosfatdegidrogenazy;

- hemopoiesis disturbance;

- hypersensitivity to pyrazyl ketone derivatives;

- the age is more senior than 60 years;

- existence in the anamnesis of a peptic ulcer of a stomach and duodenum;

- bronchospasm;

- pregnancy, feeding by a breast.

Overdose:

Symptoms - strengthening of side effects of drug.

Treatment - symptomatic.

Storage conditions:

To store in the place protected from light, at a temperature not above 25 °C.

To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

Solution for injections of 50% in ampoules on 1 ml and 2 ml, in a cardboard box on 10 pieces together with the application instruction, in a blister strip packaging on 5 or 10 pieces.