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medicalmeds.eu Medicines Antiulcerous means. Inhibitors of "the proton pump". Omeprazol

Omeprazol

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Producer: JSC AVVA RUS Russia

Code of automatic telephone exchange: A02BC01

Release form: Firm dosage forms. Capsules.

Indications to use: Peptic ulcer of 12 perstny guts. Reflux esophagitis. Zollingera-Ellison's syndrome. Erosive gastritis.


General characteristics. Structure:

Active agent: омепразол 20 mg.




Pharmacological properties:

H+-K+-ATF-azy inhibitor. Brakes activity of H+-K+-ATF-azy in covering cells of a stomach and blocks thereby a final stage of secretion of hydrochloric acid. It leads to decrease in level of basal and stimulated secretion, irrespective of the irritant nature. Owing to decrease in secretion of acid reduces or normalizes impact of acid on a gullet at patients about a reflux esophagitis.
Omeprazol renders bactericidal effect on Helicobacter pylori. H. pylori at simultaneous use of an omeprazol and antibiotics allows to stop to Eradikation quickly disease symptoms, to reach high extent of healing of the damaged mucous and permanent long remission and to reduce probability of development of bleeding from a GIT.

Pharmacokinetics. At intake it is quickly absorbed from a GIT. Gets into covering cells of a mucous membrane of a stomach. Linkng with proteins of plasma about 95%, is preferential with albumine. It Biotransformirutsya in a liver. It is removed by kidneys - 72-80%, with a stake - about 20%. T1/2 0.5-1 h. At patients with chronic diseases of a liver of T1/2 increases to 3 h.


Indications to use:

Peptic ulcer of a stomach and duodenum in an aggravation phase (including associated with Helicobacter pylori), a reflux esophagitis, Zollinger's syndrome - Ellisona, the erosive cankers of a stomach and duodenum connected with reception of NPVS.


Route of administration and doses:

Individual. At intake the single dose makes 20-40 mg. A daily dose - 20-80 mg; use frequency - 1-2 times/days. Treatment duration - 2-8 weeks.


Features of use:

Before therapy it is necessary to exclude a possibility of existence of malignant process (especially at stomach ulcer) since treatment omeprazoly can disguise symptomatology and delay the correct diagnosis.

Against the background of use of an omeprazol distortion of results of laboratory researches of function of a liver and indicators of concentration of gastrin in a blood plasma is possible.

Use in pediatrics
Due to the lack of experience of a clinical use омепразол it is not recommended to apply at children.


Side effects:

From the alimentary system: seldom - nausea, diarrhea, a lock, abdominal pains, a meteorism.
From TsNS: seldom - a headache, dizziness, weakness.
From system of a hemopoiesis: in some cases - anemia, an eosinopenia, a neutropenia, thrombocytopenia.
From an urinary system: in some cases - a hamaturia, a proteinuria.
From a musculoskeletal system: in some cases - an arthralgia, muscular weakness, a mialgiya.
Allergic reactions: seldom - skin rash.


Interaction with other medicines:

At simultaneous use cases of development of symptoms of toxic effect of benzodiazepines are described that it is connected with oppression of activity of isoenzymes of CYP3A and, apparently, CYP2C9.

At simultaneous use with an atrakuriya bezilaty effects an atrakuriya of a bezilat are prolonged.

At simultaneous use from bismuth, a trikaliya dicitrate perhaps undesirable increase in absorption of bismuth.

At simultaneous use with digoxin perhaps small increase in concentration of an omeprazol in a blood plasma.

At simultaneous use with Disulfiramum the case of disturbance of consciousness and a catatonia is described; with indinaviry - reduction of concentration of an indinavir in a blood plasma is possible; with ketokonazoly - reduction of absorption of a ketokonazol.

At prolonged simultaneous use with klaritromitsiny there is an increase in concentration of an omeprazol and klaritromitsin in a blood plasma.

Cases of reduction of removal of a methotrexate from an organism at the patients receiving омепразол are described.

At simultaneous use with theophylline perhaps small increase in clearance of theophylline.

Believe that at simultaneous use of an omeprazol in high doses and Phenytoinum increase in concentration of Phenytoinum in a blood plasma is possible.

Cases of increase in concentration of cyclosporine in a blood plasma at simultaneous use with tsklosporiny are described.

At simultaneous use with erythromycin the case of increase in concentration of an omeprazol in a blood plasma is described, at the same time efficiency of an omeprazol decreased.


Contraindications:

Chronic diseases of a liver (including in the anamnesis), hypersensitivity to an omeprazol.

Use at pregnancy and feeding by a breast
Due to the lack of clinical experience омепразол it is not recommended to apply at pregnancy. In need of use in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Use at abnormal liver functions
It is contraindicated at chronic diseases of a liver (including in the anamnesis).

Use for children
Due to the lack of experience of a clinical use омепразол it is not recommended to apply at children.


Overdose:

It is not described.


Storage conditions:

In the dry, protected from light place, at a temperature below 25 °C.
To store in the place, unavailable to children.


Issue conditions:

According to the recipe


Packaging:

Капс. 20 mg: 10 pieces.



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