Акридерм® group of companies

General characteristics. Structure:

Active ingredients: 0,64 mg of betamethasone of Dipropionas, 10 mg of Clotrimazolum, 1 mg Gentamycini sulfas.

Excipients: vaseline, propylene glycol, a liquid paraffin medical, cetostearyl alcohol, a macrogoal cetostearyl ether, Trilonum of B, dihydrophosphate sodium a dihydrate (sodium phosphate monosubstituted 2-water), the water purified.

The combined drug for external use combining antiinflammatory, antiallergic, antibacterial, antifungal action.

Pharmacological properties:

Pharmacodynamics. Betamethasone Dipropionas — the glucocorticosteroid, renders antiinflammatory, antiallergic, anti-exudative, antiedematous and antipruritic action. Slows down accumulation of leukocytes, release of lizosomalny enzymes and pro-inflammatory mediators in the inflammation center, phagocytosis oppresses, reduces vascular and fabric permeability, interferes with formation of inflammatory hypostasis.

Clotrimazolum has antifungal effect due to disturbance of synthesis of the ergosterol which is a component of a cellular membrane of mushrooms. It is active in the relation: Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furtur (Pityrosporum orbiculare).

Gentamycin — an antibiotic of a broad spectrum of activity from group of aminoglycosides. Has bactericidal effect concerning causative agents of primary and consecutive bacterial infections of skin. It is active concerning gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerugenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp. (sensitive strains of a beta and alpha and hemolitic streptococcus of group A), Staphylococcus spp. (a coagualase - positive, a coagualase - the negative and some strains producing a penicillinase).

Indications to use:

Treatment of the dermatosis complicated by primary and/or consecutive infection, a chromophytosis, limited and diffusion neurodermatitis, dermatomycoses (including inguinal, stop) caused by activators, sensitive to drug.

Route of administration and doses:

Outwardly. ^{Акридерм®} groups of companies apply with a thin layer on an affected area of skin 2 times a day — in the morning and in the evening.

Other frequency of use can be established by the doctor, proceeding from disease severity. In mild cases cream is enough to be applied, as a rule, once a day; at more severe defeats more frequent use can be necessary.

Duration of treatment depends on efficiency and portability of therapy and makes 2-4 weeks.

If clinical improvement does not occur, it is necessary to specify the diagnosis.

Features of use:

If the signs of hypersensitivity or irritation of skin connected using drug are noted it is necessary to stop treatment and to pick up to the patient adequate therapy.

At long treatment, when putting drug on the extensive surfaces of skin, when using occlusive bandages, and also at children system absorption of corticosteroids is possible.

On face skin more often than on other body surfaces after prolonged treatment atrophic changes can be shown by glucocorticosteroids of local action.

^{Акридерм®} cream is not intended to group of companies for use in ophthalmology. To avoid hit of drug in eyes.

At long use of drug its cancellation should be carried out gradually.

At pregnancy and in the period of a lactation. Safety of topical administration of glucocorticosteroids at pregnant women is not established; prescription of medicines of this group during pregnancy is justified only if the potential advantage exceeds possible risk. During pregnancy drugs of this group should not be used in high doses or a long time.

It is not established whether topical administration of glucocorticosteroids the reason of emergence them in mother's milk therefore it is necessary to resolve an issue of the breastfeeding termination can become.

Side effects:

At topical administration of glucocorticosteroids can be observed: burning, irritation, xeroderma, folliculitis, hypertrichosis, aknepodobny rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. At prolonged use, and also use of occlusive bandages — maceration of skin, consecutive infection, a skin atrophy, a heat rash, a purpura.

When drawing on extensive body surfaces, generally at children emergence of system side effects of glucocorticosteroids (a hyperglycemia, a glucosuria, reversible oppression of function of bark of adrenal glands, manifestation of a syndrome of Cushing) and gentamycin (nephrotoxic and ototoksichesky action) is possible.

At emergence of the side reactions which are not described in the instruction it is necessary to see a doctor.

Interaction with other medicines:

Interaction of drug with other medicines is not revealed.

Contraindications:

Hypersensitivity to any of drug components, a tuberculosis cutis, skin displays of syphilis, chicken pox, a herpes simplex, skin postvaccinal reactions, open wounds, the period of a lactation and children's age till 1 year, at treatment of outside otitis — perforation of a tympanic membrane.

Overdose:

The acute overdose is improbable, however, at excessive or prolonged use of drug the chronic overdose which is followed by hypercorticoidism signs is possible: hyperglycemia, glucosuria, reversible oppression of function of bark of adrenal glands, manifestation of a syndrome of Cushing.

Treatment. The corresponding symptomatic treatment is shown. In case of chronic toxic action gradual drug withdrawal is recommended.

Storage conditions:

Drug cannot be used after the expiry date specified on packaging. To store at a temperature from 15 to 25 °C. To store in the place, unavailable to children. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

On 15 or 30 g in a tuba aluminum. Each tuba together with the application instruction is placed in a pack from a cardboard.