Акридерм® group of companies

General characteristics. Structure:

Active ingredients: 0,064 mg of betamethasone of Dipropionas in terms of 100% substance, 1 g of Clotrimazolum in terms of 100% substance, 0,1 g of Gentamycini sulfas in terms of ген­тамицин.

Excipients: пропилпарагидроксибензоат (нипазол), liquid paraffin (vazeyolinovy oil), isopropyl myristate, vaseline.

The combined drug, renders antiinflammatory, antiallergic, anyotibakterialny and antifungal (fungicidal) action.

Pharmacological properties:

Pharmacodynamics. Gentamycin — an antibiotic of a broad spectrum of activity from group of aminoglycosides, works bakteritsidno. Gram-negative microorganisms - Proteus spp are highly sensitive. (indolpositive and indolnegative), Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp., Staphylococcus spp. (metitsillinorezistentny). Chuvstviyotelna: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. Rezistentna: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri.

Betamethasone - a glucocorticosteroid, renders local antiinflammatory, antiedematous, antiallergic action.

Clotrimazolum — antifungal means from group of derivatives of an imidazole for topical administration. Has effect due to disturbance of synthesis of the ergosterol which is a soyostavny part of a cellular membrane of mushrooms. Possesses a broad spectrum of activity. Aktiyoven concerning pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagro-phytes, Epidermophyton floccosum, Microsporum canis), barmy and mold mushrooms (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics. At cutaneous use of drug in therapeutic doses transdermalny absorption of active ingredients in blood very insignificant. At application on skin the intensivyonost of absorption of betamethasone depends on a condition of an epidermal barrier (the inflammation and skin diseases increase absorption). Use of occlusive bandages increases transdermalny absorption of betamethasone and gentamycin that can bring to a uvelicheyoniya of risk of development of system side effects.

Indications to use:

The simple and allergic dermatitis (which is especially complicated by secondary infection), diffusion neurodermatitis (including atopic dermatitis), limited neurodermatitis (including chronic deprive idle time), eczema, dermatomycoses (dermatofitiya, candidiasis, raznotsvetyony deprive), especially at localization in inguinal area and large folds of skin.

Route of administration and doses:

Outwardly. Ointment is applied on affected areas of skin, slightly rubbing, a small amount 2 times a day. Duration of treatment is defined individually and depends on a nozologicheyosky form and disease severity.

At a dermatomycosis of feet the average duration of treatment — 2–4 weeks. If clinical improvement does not occur in the nearest future, it is necessary to specify диаг­ноз or to change the scheme of treatment.

Features of use:

It is necessary to avoid hit in eyes.

At emergence of steady bacterial or fungal microflora it is necessary to cancel drug, to appoint the corresponding therapy.

Because children have an area of integuments in relation to body weight more, than at adults, and also epidermis is insufficiently developed, at external use of a prepayorat perhaps absorption is proportional bigger amount of active ingredients and, therefore, there is a bigger risk of development of system by-effects.

Приме­нять drug at children follows the shortest term and with observance of all measures of a preyodostorozhnost.

At pregnancy and in the period of a lactation. During pregnancy (especially in the I trimester) topical administration of ointment at pregnant women is allowed only when the estimated advantage for mother exceeds poyotentsialny risk for a fruit. In such cases use of drug has to be neproyodolzhitelny and be limited to small sites of integuments. It is not known whether drug components with breast milk are allocated. Therefore at an ointment naznayocheniya Akriderm the termination of a chest vskarmyolivaniye is recommended to group of companies in the period of a lactation.

Side effects:

Itch, burning, irritation, xeroderma, folliculitis, hypertrichosis, steroid eels, hypo - pigmentation, allergic reactions. At use of occlusive bandages — maceration, infection, an atrophy of skin, a striya, a heat rash.

At long treatment or a naneseyoniya on a big surface — development of system side effects: increase in body weight, osteoporosis, increase in arterial pressure, hypostases, ulceration of a mucous obolochyoka of digestive tract, aggravation of the hidden centers of an infection, hyperglycemia, vozyobuzhdeniye, sleeplessness, dysmenorrhea.

Interaction with other medicines:

Interaction of drug with other medicines is not revealed.

Contraindications:

Hypersensitivity to any of drug components, a tuberculosis cutis, skin displays of syphilis, chicken pox, a herpes simplex, skin postvaccinal reactions, open wounds, children's age (up to 2 years).

With care. Pregnancy (especially I trimester). Children's age from 2 to 18 years.

Overdose:

Symptoms: hypercorticoidism phenomena.

Treatment: gradual drug withdrawal. Symptomatic therapy. If necessary — correction of electrolytic disturbances.

Storage conditions:

At a temperature from 15 to 25 °C. To store in the place, unavailable to children. Not to use after expiry date. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

Ointment for external use. On 15 or 30 g in a tuba aluminum. Each tuba together with the application instruction is poyomeshchat in a pack from a cardboard.