Акридерм® GHENT

General characteristics. Structure:

Active ingredients: 0,064 mg of betamethasone of Dipropionas, 0,1 g of Gentamycini sulfas in a pereyoscheta on active anhydrous agent.

Excipients: пропилпарагидроксибензоат (нипазол), liquid paraffin (liquid paraffin), isopropyl palmitate, vaseline.

Antiinflammatory, antiallergic, antipruritic, antibacterial sredyostvo.

Pharmacological properties:

Pharmacodynamics. Betamethasone Dipropionas — a synthetic glucocorticosteroid (GKS) rendering an antiinflammatory, antiallergic, antipruritic and vasoconstrictive deyyostviye. At topical administration narrows vessels, removes an itch, reduces allocation of meyodiator of an inflammation (from eosinophils and mast cells), interleykin 1 and 2, gamma interferon (from lymphocytes and macrophages), brakes activity of hyaluronidase and poyonizhat permeability of a vascular wall. Interacts with specific retseptoyora in cell cytoplasm, stimulates synthesis of MRNK inducing formation of belyok including the lipokortin mediating cellular effects. Lipokortin oppresses A2 phospholipase, blocks release of arachidonic acid and biosynthesis of the endoperoxides, prostaglandins, leukotrienes (promoting development of an inflammation, an allergy and other pathological processes).

Gentamycin — an antibiotic of a broad spectrum of activity of group of aminoglycosides. Okazyvayoet bactericidal action also provides highly effective topical treatment of pervichyony and consecutive bacterial infections of skin. It is active concerning gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulyogaris, Klebsiella pneumoniae; and gram-positive bacteria: Streptococcus spp. (sensitive strains (beta and alpha and hemolitic streptococcus of group A), Staphylococcus aureus (koagulazopolozhitelny, koagulazootritsatelny strains and some strains, proyodutsiruyushchy penicillinase).

Pharmacokinetics. At external use of drug in therapeutic doses transdermalny vsasyvayony active ingredients in blood very insignificant. Use occlusal по­вязок increases absorption of betamethasone and gentamycin that can bring to a uvelicheyoniya of risk of development of system side effects.

Indications to use:

The dermatitis (simple and allergic) especially for the second time infected eczema (atopic, children's, monetovidny), atopic dermatitis (neurodermatitis diffusion), idle time chronic deprive (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, an intertrigo, psoriasis, an itch.

Route of administration and doses:

Adults. Ointment is applied a thin layer on an affected area of skin and surrounding fabrics by 2 times a day (in the morning and in the evening), slightly rubbing roundabouts. On sites of skin with thicker epidermis and in places from which drug easily is eliminated (palms and steps) ointment should be applied to a thicket. Duration of treatment depends on efficiency and portability of therapy and makes, as a rule, no more than 2-4 weeks.

Children. To children appointment of drug since two years only according to strict indications and under observation of the doctor is allowed. Because children have an area of integuments in relation to body weight more, and also epidermis is insufficiently developed, at external use of drug perhaps absorption is proportional bigger amount of active ingredients and there is, sledovayotelno, a bigger risk of development of system by-effects. It is necessary to use drug at children the shortest term and with observance of all measures of a predosyotorozhnost.

Features of use:

^{Akriderm® ointment} of GHENT is not recommended to be applied on face skin and a pilar part of the head.

Use of ointment under occlusive bandages, behind an exception слу­чаев is not recommended, when necessary.

It is impossible to allow hits ^{of Akriderm® ointment} of GHENT in eyes and on a periorbital obyolast.

^{Акридерм®} ointment for external use it is not necessary to use GHENT for treatment of varicose trophic ulcers of a shin and open wounds.

At prolonged use ^{of Akriderm® ointment} of GHENT on the big surfaces of skin with the broken integrity there is potentiality of absorption of a gentamiyotsin and, respectively, development of symptoms of ototoxicity.

Some body parts (inguinal folds, axillary hollows and perianal об­ласть), in bigger a stepepa are subject to risk of emergence of striya. Therefore the dlitelyyonost of use of drug on these body parts has to be limited. In cases of fungal superinfection additional use of protivoyogribkovy medicine is necessary.

Influence on ability of control of vehicles and mechanisms. Data on an adverse effect of drug on ability to manage transportyony means and mechanisms are absent.

At pregnancy and in the period of a lactation. Safety of topical administration of glucocorticosteroids at pregnant women not an ustanovleyona; prescription of medicines of this group during pregnancy is justified only if the potential advantage for mother exceeds possible risk for a fruit. During pregnancy drugs of this group should not be used in vysoyoky doses or a long time.

It is not established whether drug gets into breast milk therefore it is necessary to refuse breastfeeding.

Side effects:

Very seldom at use ^{of Akriderm® ointment} of GHENT are noted: burning sensation, eriyotema, exudation, disturbance of pigmentation and itch.

The side reactions which are found at use of local GKS: (especially at a primeyoneniya of occlusive bandages): burning sensation, an itch, a xeroderma, a folliculitis, гипер­трихоз, eels, hypopigmentation, perioral dermatitis, allergic contact deryomatit, maceration of skin, development of consecutive infection, an atrophy of skin, a striya, a heat rash.

Exclusively seldom (in cases of considerable system absorption of gentamycin) suyoshchestvut danger of injury of an acoustical nerve and vestibular mechanism, сопровож­дающегося a sonitus and a hearing disorder. Such by-effects develop when patients at the same time accept ototoksichny or nefrotoksichny drugs and at a renal failure.

At long treatment or drawing on a big surface — development of sisyotemny side effects of glucocorticosteroids: increase in body weight, osteoporosis, increase in arterial pressure, hypostases, ulceration of a mucous membrane of digestive tract, aggravation of the hidden centers of an infection, hyperglycemia, excitement, sleeplessness, disturbances of a menstrual cycle.

Children have an oppression of system hypophyses-hypothalamus-adrenal glands, Cushing's syndrome, growth zayoderzhka, lag in a body weight increase, increase in intracranial pressure (betamethasone).

Interaction with other medicines:

Interactions of drug with other medicines are not revealed.

Contraindications:

Hypersensitivity to betamethasone, gentamycin or to any of the excipients which are a part of drug.

Tuberculosis cutis, vaccination, viral infections of skin, perioral dermatitis, rozatse. Skin displays of syphilis, skin postvaccinal reactions, children's age (up to 2 years).

Overdose:

Symptoms: At prolonged use of local GKS in high doses perhaps podavyoleny functions of adrenal glands with development of secondary adrenal insufficiency and symptoms of a hypercorticoidism, including Cushing's syndrome.

At single overdose of gentamycin of emergence of any symptoms it does not ozhiyodatsya.

Prolonged treatment by gentamycin in the raised doses can lead to growth of nechuvstyovitelny flora.

Treatment: Symptomatic. Acute symptoms of a hypercorticoidism are usually reversible. If necessary carry out correction of electrolytic balance.

Storage conditions:

At a temperature from 15 to 25 °C. To store in the place, unavailable to children. Not to use after expiry date. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

On 15 and 30 g in a tuba aluminum. Each tuba together with the application instruction is placed in a pack from a cardboard.