Acetylsalicylic acid

General characteristics. Structure:

Active ingredient: 500 mg of acetylsalicylic acid.

The non-steroidal anti-inflammatory drug possessing febrifugal, analgeziruyushchy, antiinflammatory, anti-aggregation action.

Pharmacological properties:

Pharmacodynamics. Acetylsalicylic acid inhibits not selectively TsOG-1 and TsOG-2 cyclooxygenases, is irreversible brakes a cyclooxygenase way of metabolism of arachidonic acid, blocks synthesis of PG and thromboxane.

Reduces a hyperemia, exudation, permeability of capillaries, activity of hyaluronidase, limits power ensuring inflammatory process by oppression of products of ATP. Influences the subcrustal centers of thermal control and painful sensitivity. Reduces algogenny effect of bradikinin. Reduction of contents Tkhv2 in thrombocytes leads to irreversible suppression of aggregation, expands vessels a little. The essential inhibition of a skleivayemost of platelets is reached at doses to 300 mg/days. Stimulates removal of uric acid as its reabsorption in tubules of kidneys is broken.

Indications to use:

Feverish syndrome at infectious and inflammatory diseases. Pain syndrome (various genesis): a headache (including connected with an alcoholic abstinence syndrome), migraine, a dentagra, neuralgia, a chest radicular syndrome, a lumbago, muscular pains, pains at periods.

Route of administration and doses:

For reduction of irritant action by digestive tract drug should be accepted after food, washing down with water, milk or alkaline mineral water.

At a pain syndrome of weak and average intensity and feverish states the single dose for adults makes 250-500 mg, the maximum single dose – 1000 mg. If necessary it is possible to accept drug 3-4 times a day with an interval not less than 4 hours. The maximum daily dose – 3000 mg.

It is not necessary to accept drug more than 5 days as anesthetic and more than 3 days as an antipyretic without appointment of the doctor.

Features of use:

In 5-7 days prior to surgical intervention it is necessary to cancel reception (for reduction of bleeding during operation and in the postoperative period).

Irritant action on a GIT decreases at appointment after food. During long therapy it is regularly recommended to make blood test and to investigate kcal on the occult blood.

It is not recommended for stopping of a feverish syndrome at children.

Side effects:

Acetylsalicylic acid can cause allergic reactions, a small tortoiseshell, a Quincke's disease, various a dieback, an eosinophilia, a bronchospasm. At hypersensitivity to acetylsalicylic acid the acute anaphylaxis can develop, and at the persons having bronchial asthma increase and strengthening of attacks is noted.

Formation on the basis of the gaptenovy aspirinovy mechanism of bronchial asthma and an "aspirinovy" triad (the eosinophilic rhinitis recuring nose polyposes, hyperplastic sinusitis) is possible.

At long reception of acetylsalicylic acid development of ototoksichesky, nephrotoxic and hepatotoxic effects is possible. At intake drug has specific ulcerogenic effect, causes erosive and cankers of a mucous membrane of a stomach and a 12-perstny gut, gastrointestinal bleedings.

It is necessary to report about all side (unusual) effects including which are not stated above to the attending physician.

Interaction with other medicines:

Increases toxicity of a methotrexate, effects of narcotic analgetics, antihyperglycemic means, peroral antidiabetic drugs, non-steroidal anti-inflammatory drugs, heparin, Reserpinum, indirect anticoagulants, corticosteroids, trombolitik and inhibitors of aggregation of thrombocytes, reduces – antihypertensives. Drug to some extent reduces influence of Spironolactonum, furosemide, uricosuric means.

Antihistamines, acetaminophen, caffeine increase risk of development of by-effects. Glucocorticoids make negative impact on a mucous membrane of a GIT.

At use of acetylsalicylic acid by the patients receiving anti-diabetic means it is regularly necessary to control sugar level in blood.

Contraindications:

Hypersensitivity; GIT erosive cankers (in an aggravation phase), gastrointestinal bleeding; "aspirinovy" triad; hemorrhagic diathesis (hemophilias, angiohemophilia, teleangiectasias, prothrombinopenia, thrombocytopenia, Werlhof's disease); the stratifying aortic aneurysm, portal hypertensia; deficit of vitamin K; liver/renal failure; pregnancy (I and III trimesters), lactation period; deficit glyukozo-6-fosfatdegidrogenazy, children's age (up to 15 years - risk of development of a syndrome to Reja at children with a hyperthermia against the background of viral diseases).

Overdose:

The overdose is possible at one-time introduction of excessively high doses of drug or at prolonged use.

Symptoms: salitsilizm syndrome (nausea, vomiting, sonitus, febricula, fever). More serious poisoning – a stupor, spasms and a coma, not cardiogenic fluid lungs, sharp dehydration, disturbances of BRAIDS (in the beginning - a respiratory alkalosis, then a metabolic acidosis), a renal failure and shock.

Treatment: immediate hospitalization, gastric lavage, use of absorbent carbon, check of BRAIDS. Depending on a condition of BRAIDS and electrolytic balance carry out infusional administration of solutions of Natrii hydrocarbonas, sodium of citrate and sodium of a lactate; at рН urine from 7,5 to 8,0 and contents of salicylates in a blood plasma more than 500 mg/l (for adults) or 300 mg/l (for children) carry out an intensive care by alkaline diuretics; at serious poisonings carrying out a hemodialysis is shown; liquid loss completion; symptomatic treatment.

Issue conditions:

Without recipe

Packaging:

Mg tablets 500 in packaging No. 10, No. 20 and No. 30.