Kromogeksal spray

General characteristics. Structure:

Active agent: sodium кромогликат 20,0 mg.

Excipients: a benzalkoniya chloride, sodium chloride, dinatrium эдетат, sorbitol liquid uncrystallized, dihydrophosphate sodium a dihydrate, hydrophosphate dinatrium dodecahydrate, water for injections.

Pharmacological properties:

Pharmacodynamics. Antiallergic means, has membrane stabilizing effect, blocks receipt of calcium ions in a mast cell, preventing its degranulation and release of a histamine, bradikinin, prostaglandins, leukotrienes (including slowly reacting substance) and other biologically active agents. Drug is most effective as prophylactic. The noticeable clinical effect occurs in several days or weeks of reception.

Pharmacokinetics. At intranasal introduction to a system blood stream less than 7% are absorbed. Communication with proteins of plasma – 65%. It is not metabolized, removed by kidneys and through intestines in not changed look (approximately in equal quantities within 24 hours after use). An elimination half-life – 1,5 hours. A part of active agent is swallowed (about 1%) and allocated through digestive tract without essential absorption.

Indications to use:

Prevention and treatment:

- pollinosis
- allergic rhinitis (including, seasonal and/or year-round).

Route of administration and doses:

Intranazalno. To adults and children 5 years are more senior it is recommended to enter into each nasal course on 1 aerosol dose (2,8 mg of a kromoglikat of sodium) 4 times a day.
If necessary it is possible to apply on 1 aerosol dose as much as possible up to 6 times (as much as possible – 16,8 mg) in day in each nasal course.
After achievement of therapeutic effect the frequency of use of Kromogeksal it is possible to reduce and use drug only at contact with allergens (house dust, disputes of mushrooms, pollen).
Course of treatment – 4 weeks. Cancellation should be made gradually within 1 week.
For administration of drug it is necessary to remove a protective cap, to enter the raspylitelny device into a nostril and to press strongly the raspylitelny mechanism. At the first use of a bottle it is necessary to press several times the raspylitelny mechanism before emergence of droplets of liquid. 

Features of use:

At purpose of kromoglitsiyevy acid for inhalation use are described (relationship of cause and effect is not proved): at 1 of 10 thousand patients - a Quincke's disease, a bronchospasm, cough, dizziness, a dysuria (including increase of an urination), a headache, an arthralgia, puffiness of joints, throat hypostasis, dacryagogue, nausea, a nose congestion, rash, swelling of parotid sialadens, a small tortoiseshell.
Are noted at 1 of 100 thousand patients - anemia, exfoliative dermatitis, a pneumorrhagia, hoarseness of a voice, a mialgiya, a nephropathy, a periarteritis, a pericardis, peripheral neuritis, a photodermatitis, a polymiositis, pulmonary infiltrates with an eosinophilia. Messages on similar effects when using forms for intranasal use were not.
Therapy should be continued during the entire period of effect of allergen.
If the irritation or burning of a mucous membrane of a nasal cavity does not pass or amplifies, the treatment termination is necessary.

Side effects:

From respiratory system: the irritation or burning of a mucous membrane of a nasal cavity, frequent sneezing, cough, a rhinorrhea, is rare - nasal bleedings.
Allergic reactions: urticaria, a skin itch, skin rash, puffiness of the person, lips or a century, the complicated breath, the complicated swallowing.
Others: unpleasant flavoring feelings, headache.

Interaction with other medicines:

Kromoglitsiyevy acid can increase efficiency of H1-gistaminoblokatorov.

Contraindications:

- hypersensitivity to a kromoglikat of sodium or to any other component of drug
- children's age up to 5 years
- pregnancy and period of a lactation.

With caution it is necessary to take drug at patients with a renal and/or liver failure, with polyps of a nasal cavity.

Overdose:

Data on overdose of drug are absent.

Storage conditions:

At a temperature not above 25 °C in the place protected from light. To store in the place, unavailable to children!

Issue conditions:

Without recipe

Packaging:

Spray nasal dosed 2%
On 15 ml or 30 ml in polyethylene bottles with the portioning device closed by a polyethylene lid.
One bottle and the application instruction in a cardboard box.