Pyrantelum

General characteristics. Structure:

Active ingredient: Pyrantelum памоат 725 mg (250 mg of Pyrantelum of the basis are equivalent).

Excipients: starch, gelatin, acacias gum, methylparahydroxy-benzoate, пропилпарагидроксибензоат, sodium carboxymethylstarch, talc, magnesium stearate, silicon dioxide colloid (aerosil).

Pharmacological properties:

Pharmacodynamics. Protivogelmintny drug, causes neuromuscular blockade of helminths, sensitive to it, and provides their exile without excitement and stimulation of migration of the struck worms. In a gleam of intestines it is effective against mature and unripe forms of sensitive helminths of both sexes.

Pyrantelum is highly effective against the invasions caused by pinworms (Enterobius vermicularis), ascarids (Ascaris lumbricoides), ankylostomas (Ancylostoma doudenale and Necator americanus) against trichuriasis activators (Trichostrongylus orientalis and Trichostrongylus colubriformis).

It is moderately active concerning a threadworm (Trichirus frischiura).

Pharmacokinetics. Pyrantelum is practically not absorbed from the digestive tract (DT). After reception of a single dose of 10 mg/kg of body weight concentration of drug in a blood plasma makes 0,005-0,13 mkg/ml within 1-3 hour. It is metabolized partially in a liver to N-methyl-1,3-propandiamina.

It is removed through intestines — about 93% in an invariable look, 7% — kidneys in an invariable look or in the form of a metabolite.

There are no penetrations of drug given relatively through a placenta and in maternal milk, and also concerning distribution of drug in fabrics and liquids of an organism (theoretically the resorption of drug is minimum).

Indications to use:

• Ascaridosis
• Enterobiosis
• Ankilostomidoz
• Necatoriasis
• Trichuriasis

Route of administration and doses:

At an ascaridosis and an enterobiosis, at the mixed invasions these helminths — inside, once, after a breakfast at the rate of 10 mg/kg.

Depending on age and the weight of the patient the following dosages are recommended:
- to adults and children 12 years — 750 mg are more senior, at body weight more than 75 kg — 1 g.
- to children from 6 months to 2 years — 125 mg, 2-6 years — 250 mg, 6-12 years — 500 mg.

In order to avoid a self-invasion repetition of a course in 3 weeks after the first reception is allowed. In case infection only with a human nematode is noted, Pyrantelum can be appointed in the smallest dose of 5 mg/kg once.

At a dochmiasis, a necatoriasis combination to an ascaridosis or other combined gelmintny defeats appoint within 3 days on 10 mg/kg/days.

At massive invasions of Necator americanus reception within 2 days — on 20 mg/kg/days is recommended. The tablet before a proglatyvaniye needs to be chewed.

Features of use:

After reception of Pyrantelum laxative is not appointed.

At an enterobiosis it is necessary to carry out simultaneous treatment of all jointly of the living persons.

In 14 days after treatment it is necessary to conduct control parasitological researches.

Is more effective at treatment of the patients infected with a 12-perstny ankylostoma, than the American ankylostoma.

In the presence of a helminthic invasion at one of the family members or a group of persons who are in close relationship contact persons are recommended to carry out therapy by everything.

Careful cleaning of premises and cleaning of clothes for destruction of eggs of helminths serves as prevention of reinfection.

Influence of drug on driving of the car and control of mechanisms. Considering possible side effects from a nervous system at therapy by Pyrantelum, it is necessary to be careful during the driving of the car and service of the mechanical equipment.

Side effects:

Side effects are shown seldom, they are short-term and disappear after the treatment termination.

From a GIT and a liver: nausea, vomiting, diarrhea, pains and spasms in a stomach, a loss of appetite, it is rare — increase in activity of "hepatic" transaminases.

From a nervous system: seldom — a headache, dizziness, drowsiness or sleeplessness, weakness; in isolated cases — a hearing disorder, hallucinations, confusion of consciousness, paresthesia (communication of these symptoms with administration of drug is not proved).

Others: skin rash, small tortoiseshell, fervescence.

Interaction with other medicines:

It is not necessary to appoint along with piperazin (weakening of action).

Increases concentration of theophylline in a blood plasma.

Contraindications:

• Hypersensitivity
• Myasthenia (treatment period)

With care. Pregnancy, the lactation period, a liver failure, children's age (up to 6 months)

Overdose:

Cases of overdose are not described. In case of overdose it is necessary to appoint a symptomatic treatment.

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 25 °C. To store in the places unavailable to children. Not to use after a period of validity. A period of validity - 3 years. 

Issue conditions:

According to the recipe

Packaging:

Tablets on 250 mg. 3 tablets in a strip from aluminum foil. 1 strip in a cardboard pack together with the application instruction.