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medicalmeds.eu Medicines Antiallergic means — H1-histamine of receptors a blocker. Diazolinum (dragee)

Diazolinum (dragee)

Препарат Диазолин(драже). ОАО "Фармак" Украина


Producer: JSC Pharmak Ukraine

Code of automatic telephone exchange: C01DA08

Release form: Firm dosage forms. Tablets.

Indications to use: Pollinosis. Allergic rhinitis (cold). Small tortoiseshell. Medicinal allergy. Dermatitis. Skin itch. Eczema. Neurodermatitis.


General characteristics. Structure:

Active ingredient: mebhydrolin;

1 dragee contains a mebgidrolin in terms of 100% dry matter of 50 mg (0,05 g) or 100 mg (0,1 g);

excipients: sucrose, starch syrup, talc, wax yellow, sunflower oil.




Pharmacological properties:

Mebgidrolin treats antihistaminic drugs, is a blocker of Hl-receptors of a histamine. Mebgidrolin weakens spazmogenny effect of a histamine concerning unstriated muscles of bronchial tubes, intestines, and also its influence on permeability of vessels. Unlike antihistaminic drugs of the first generation (Dimedrol, Suprastinum) has less expressed sedative and somnolent effect. Possesses slight m-holinoblokiruyushchimi and the anesthetizing properties.

It is quickly soaked up from a digestive tract. Bioavailability fluctuates within 40-60%. The therapeutic effect develops 15-30 minutes later, the maximum action is observed in 1-2 hours. Duration of effect can reach 2 days. Drug practically does not get through a blood-brain barrier, is metabolized in a liver by methylation, induces liver enzymes, is removed from an organism by kidneys.


Indications to use:

Prevention and treatment of seasonal and allergic rhinitis, pollinosis, small tortoiseshell, food and medicinal allergy, the dermatosis which is followed by a skin itch (eczema, neurodermatitis).


Route of administration and doses:

Диазолин® to appoint inside, after food, to adults and children from 12 years on 100-200 mg 1-2 times a day. The maximum doses for adults: one-time – 300 mg, daily – 600 mg.

To children of 5-12 years to appoint 50 mg 1-3 times a day, children are 3-5 years old – on 50 mg 1-2 times a day. Duration of treatment is determined by the doctor depending on the nature of a disease, clinical effect and portability of drug.


Features of use:

Диазолин® with care appoint at a heavy liver and/or renal failure (dose adjustment and increase in intervals between receptions is possible). During treatment of Diazolinom®upotrebleniye of alcoholic beverages it is not recommended.

Use during pregnancy or feeding by a breast. During pregnancy or feeding by a breast it is contraindicated to use drug.

Ability to influence speed of response at control of motor transport or work with other mechanisms. At use of drug it is not recommended to manage motor transport and to be engaged in other potentially dangerous types of activity which demand concentration of attention.

Children. To use drug to children 3 years are more senior.


Side effects:

From the alimentary system: Диазолин® can irritate mucous membranes of digestive tract that is sometimes shown by the dispeptic phenomena (heartburn, nausea, pain in epigastric area).

From the central nervous system: dizziness, paresthesias, increased fatigue, drowsiness, illegibility of visual perception, delay of speed of reactions, tremor, uneasiness (night).

Others: dryness in a mouth, disturbances of an urination, allergic reactions. Emergence of a granulocytopenia and agranulocytosis is extremely seldom possible.

At children paradoxical reactions are sometimes observed: hyperexcitability, tremor, sleep disorders, irritability.

In isolated cases in the post-registration period the following side reactions were noted: headache, itch, rashes, urticaria, Quincke's edema.


Interaction with other medicines:

Диазолин® exponentiates effect of the somnolent, sedative and other drugs oppressing the central nervous system and also alcohol.


Contraindications:

Hypersensitivity to drug components. A peptic ulcer of a stomach and duodenum in the period of an aggravation, inflammatory diseases of digestive tract, a pylorostenosis, a prostate hyperplasia closed-angle glaucoma, epilepsy, disturbances of a cordial rhythm.


Overdose:

At overdose of drug the risk of emergence of the side reactions described in appropriate section increases. In this case drug is cancelled, in case of need hold events of the general detoxication (a gastric lavage, an artificial diuresis), symptomatic therapy.


Storage conditions:

Period of validity 3 years 6 months. Not to use drug after the termination of the period of validity specified on packaging. To store in the place protected from light at a temperature not above 25 °C. To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

On 10 dragees in the blister without investment in a pack.

On 10 dragees in the blister. On 2 blisters in a pack.



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