Orvikold

General characteristics. Structure:

Active ingredient: 325 mg of paracetamol, 20 mg of pheniramine of a maleate, 10 mg of Phenylephrinum of a hydrochloride.

Excipients: citric acid anhydrous, sugar (powder for preparation of solution for intake).

Excipients: citric acid anhydrous, sugar, fragrance (orange or a lemon, or raspberry) (powder for preparation of solution for intake (orange, a lemon, or raspberry)).

Symptomatic medicine against symptoms of flu and cold. Easily copes with symptoms of flu and cold, including fever and a fever, a headache, cold, a nose congestion, sneezing and body pain.

Pharmacological properties:

Pharmacodynamics. The combined drug, possesses the febrifugal, antiinflammatory, antiedematous, anesthetizing and antiallergic action.

Paracetamol possesses febrifugal, analgeziruyushchy and some antiinflammatory action, reduces the pain syndrome which is observed at catarrhal diseases, a pharyngalgia, a headache, muscular and joint pain, reduces high temperature. Blocks cyclooxygenase of the first and second types preferential in the central nervous system. Due to the lack of the blocking influence on synthesis of prostaglandins in peripheral fabrics, does not influence a water salt metabolism (Na delay + and waters) and a mucous membrane of digestive tract.

Phenylephrinum the hydrochloride has sympathomimetic effect: reduces a hyperemia and puffiness, causes vasoconstriction of a mucous membrane of a nose and okolonosovy bosoms.

Pheniramine the maleate is H1 blocker – receptors, has antiallergic effect: reduces expressiveness of exudative local displays of an infection, stops dacryagogue, reduces an itch in eyes and in a nose, eliminates a rhinorrhea.

Indications to use:

Short-term symptomatic treatment of flu and cold, including fever and a fever, a headache, cold, a nose congestion, sneezing and body pain.

Route of administration and doses:

To dissolve contents of 1 package in a glass of boiled hot water and to drink hot. To adults and children 12 years on 1 package each 4-6 hours (as required for relief of symptoms), but no more than 3 packages a day are more senior. The single dose should not exceed 1 package. 7 days are not recommended to use drug longer.

Features of use:

Drug is contraindicated during pregnancy or feeding by a breast.

During treatment it is not recommended to manage motor transport and to work with the difficult mechanisms demanding the increased concentration of attention and high speed of psychomotor reactions. At simultaneous use of sedatives, tranquilizers or alcohol drowsiness can amplify.

During treatment it is necessary to be careful during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions (contains Rimantadinum).

It is impossible to exceed the recommended dose or to accept drug more than 7 days in a row. It is necessary to consult with the doctor if symptoms:

- do not improve within 7 days;

- are followed by fever which keeps more than 3 days;

- include a pharyngalgia which does not pass more than 3 days, are followed by fever, a headache, rashes, nausea or vomiting.

It is necessary to avoid simultaneous use of other medicines containing paracetamol.

With care use drug at patients with a prostatauxe, diseases of a thyroid gland, liver and kidneys, bradycardia, acute pancreatitis, at patients 70 years with cardiovascular diseases are more senior (because of possible manifestation of vasoconstrictive action of Phenylephrinum).

The patients receiving a course of treatment other medicines should not accept Orvikold without appointment of the doctor.

Phenylephrinum can cause false positive results of a drug test in athletes.

At use of drug it is not recommended to take alcohol as ethanol at a concomitant use of paracetamol can cause an abnormal liver function.

It is not necessary to use drug from the damaged bags.

Side effects:

Most often: dizziness, dryness in a mouth or a throat, fatigue, a headache, concern, nervousness, tachycardia, tachycardia, are seldom noted excitement, a sleep disorder, hypostases.

The side reactions given below are observed seldom.

Allergic reactions: itch, rash, urticaria; in isolated cases - erythematic and other skin reactions, petechias, a Quincke's disease, a bronchospasm, falling of arterial pressure even to a depressed case, an anaphylaxis.

From the alimentary system: digestion disturbances, including a lock, nausea, vomiting, diarrhea or a meteorism, pains in epigastriums, an abnormal liver function.

From endocrine system: fluctuations of level of sugar in blood.

From a nervous system: confusion of consciousness, vestibular disturbances.

The side reactions caused by paracetamol: thrombocytopenia, a leukopenia, hemolitic anemia, in isolated cases - an agranulocytosis. Patients with intolerance of acetylsalicylic acid (5-10%) react also to paracetamol (for example, asthmatics).

The side effects caused by Phenylephrinum: increase in the ABP, heartache, mydriasis, vision disorder and accommodations, increase in intraocular pressure and potential impact on endocrine and other regulators of metabolic processes, disturbance of an urination.

The side effects caused by pheniramine: a xerophthalmus, sleeplessness, in some cases - a coma, spasms, dyskinesia, changes of behavior.

Unlike antihistaminic drugs II of generation, use of pheniramine is not associated with prolongation of an interval of QTc and arrhythmia.

Interaction with other medicines:

Medicamentous interactions with paracetamol are usually insignificant, but amplify when the accompanying medicines are such as anticoagulants (warfarin and coumarin) also anticonvulsant medicines with a low therapeutic index. Simultaneous use of paracetamol with NPVP can increase their nephrotoxicity. Pharmakodinamichesky interactions can arise with other soothing drugs, such as caffeine, opiates; barbiturates reduce febrifugal effect. The elimination half-life of chloramphenicol increases. Probenetsid, холестирамин suppress paracetamol metabolism. Treatment of tuberculosis rifampicin and an isoniazid increases гепатоксичнисть paracetamol. Antiepileptic means (phenobarbital, Phenytoinum, carboazepine) do not increase risk of a hepatotoxic action.

Phenylephrinum a hydrochloride it is not necessary to apply with MAO inhibitors, with blockers α-and β-adrenoceptors, anti-hypertensive means, derivatives of a fenotiazin (for example promethazine), bronkhodilatatorny sympathomimetic means, tricyclic antidepressants, guanetidiny or atropine, foxglove alkaloids, Rauwolfia alkaloids, indometacin, metildopy, GKS; drugs which influence appetite, amfetaminopodobny psychostimulants, stimulators of childbirth, anesthetics, ergot alkaloids.

Pheniramine the maleate exponentiates effect of the medicines oppressing the central nervous system (for example, antiparkinsonichesky and antipsychotic means), and also alcohol, suppresses effect of anticoagulants and interacts with progesterone, Reserpinum, thiazide diuretics. Oral contraceptives can lead to reduction of efficiency of antihistamines.

Contraindications:

Hypersensitivity to drug components. Heavy cardiovascular, liver or renal failure, inborn hyperbilirubinemia, arterial hypertension; a pheochromocytoma, a thyrotoxicosis, prostate adenoma with the complicated urination, obstruction of a neck of a bladder, a blood disease, piloroduodenalny obstruction, stenosal stomach ulcer and a duodenum, a diabetes mellitus, diseases of lungs (including bronchial asthma), glaucoma, deficit glyukozo-6-fosfatdegidrogenazy, epilepsy, alcoholism, the accompanying treatment by MAO inhibitors and within 2 weeks after the termination of their use.

Overdose:

The symptoms caused by paracetamol: the hepatotoxic effect, in hard cases develops the liver necrosis which is followed by nausea, vomiting, an abdominal pain which can develop within 24-48 hours after overdose. Disturbance of metabolism of glucose and a metabolic acidosis, an acute renal failure with a necrosis of tubules; arrhythmia, pancreatitis, sulfhemoglobinemia, methemoglobinemia, anemia;

The symptoms caused by potentiation of parasympathetic action of an antihistaminic component and sympathomimetic action of Phenylephrinum of a hydrochloride: hemodynamic changes and cardiovascular insufficiency with respiratory depression, drowsiness behind which excitement is possible (especially at children); depression, ulcers of a mucous membrane of a mouth, vision disorder, headache, dizziness, sleeplessness, coma, spasms, changes of behavior, arterial hypertension, bradycardia atropinopodobny "psychosis".

Treatment: a gastric lavage, intravenous or oral administration of N-Acetylcysteinum as a paracetamol antidote, reception of absorbent carbon, a salt purgative, monitoring of breath and blood circulation (it is impossible to apply adrenaline). Symptomatic treatment and maintenance therapy. In case of spasms appoint diazepam.

At arterial hypotension it is possible to apply blockers of α-adrenoceptors or vasoconstrictors.

Storage conditions:

In the place protected from moisture and light at a temperature not above 25 °C. To store in the places protected from children. Period of storage 2 years.

Issue conditions:

Without recipe

Packaging:

On 10 g of powders bags from the combined material. On 5, 10 or 15 bags in cardboard packaging together with the application instruction.