Norfloksatsin-Zdorovye, the tab. on 0,4 g No. 10

General characteristics. Structure:

International and chemical names: norfloxacin; 1-etil-6-ftor-4-okso-7-(piperazin-1-silt) - 1,4-dihydroquinoline-3-carboxylic acid;
main physical and chemical properties: tablets, coated, from color, white to white with a yellowish shade. On cross section two layers are visible;
structure: 1 tablet contains norfloxacin 0,4 g;
excipients: tselaktoza, sodium of a kroskarmeloz, potato starch, macrogoal (polyethyleneglycol-4000), talc, silicon dioxide colloid anhydrous (aerosil), calcium stearate, gipromelloz (gidroksipropilmetiltsellyuloz), коповидон (plazdon-S-630), lactoses monohydrate, titanium dioxide.

Pharmacological properties:

Pharmacodynamics. Synthetic antibacterial drug of a ftorkhinolonovy row with a wide range of antimicrobic action which mechanism is based on inhibition the DNK-girazy of a bacterial cell breaking protein synthesis and leads to death of microorganisms.
It is active concerning a wide range of gram-positive and gram-negative microorganisms. Norfloxacin is active concerning the microorganisms steady against effect of penicillin, cephalosporins, aminoglycosides, tetracyclines, streptocides. Microorganisms, resistant to antibiotics of structurally unrelated groups, have no cross norfloxacin resistance.
Gram-negative microorganisms are sensitive to norfloxacin: E. coli, Citrobacter spp., Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Serratia spp., Neisseria gonorrhoeae, Pseudomonas aeruginosa, some strains of representatives of the sort Aeromonas, Campylobacter, Klebsiella, Providencia, Salmonella, Shigella, Vibrio, Yersinia; gram-positive microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus agalactiae.
Norfloxacin is inefficient concerning strict anaerobes, viruses, mushrooms, protozoa, chlamydias, mycoplasmas, mycobacteria.

Pharmacokinetics. It is well soaked up from a digestive tract (an absorption indicator – more than 20-40%), meal slows down absorption. The maximum concentration in a blood plasma is reached in 1 h after intake. Communication with proteins of plasma – 10–15%. Norfloxacin well gets into fabrics of an urogenital path, creates high concentration in bile, gets through a placenta. About 30% of a dose are removed in not changed view with urine for 24 h, creating high concentration in urine, about 30% are removed with a stake.

Indications to use:

The infectious and inflammatory diseases caused by microorganisms, sensitive to norfloxacin: the acute and persistent infections of uric ways (complicated and uncomplicated); infections of generative organs (prostatitis, epididymite, cervicitis, gonococcal infections, шанкроид); acute bacterial gastroenteritis, typhoid; digestive tract infections (salmonellosis, shigellosis, "diarrhea of travelers"); prevention of sepsis at patients with a neutropenia; respiratory infections, infections of an ear, throat and nose (acute and chronic average otitis, chronic sinusitis, acute tonsillitis); prevention of bacterial infections at patients with a granulocytopenia.

Route of administration and doses:

Inside, for an hour to or in 2 h after food.
At uncomplicated infections of uric ways – on 400 mg 2 times a day within 3–10 days, at the complicated infections of uric ways – on 400 mg 2 times a day within 10–20 days, at a persistent recurrent infection of uric ways – up to 12 weeks. At an acute uncomplicated gonococcal urethritis, pharyngitis, a proctitis, a cervicitis – once 800–1 200 mg. At an acute bacterial gastroenteritis – on 400 mg 2–3 times a day within 5 days, at a typhoid – on 400 mg 2 times a day within 14 days. For prevention of sepsis with a neutropenia – on 400 mg 2–3 times a day within 8 weeks. At infections of an ear, throat, nose and respiratory tracts – on 400 mg 2 times a day within 3–25 days. Duration of antimicrobic action – about 12 h.
The patient with a renal failure (clearance of creatinine less than 30 ml/min.) appoint 400 mg/days.

Features of use:

With care appoint the patient with epilepsy, with a convulsive syndrome and renal failures and a liver.
During treatment patients have to receive enough liquid in order to avoid development of a crystalluria, avoid excessive insolations.
At treatment by norfloxacin it is necessary to avoid action of UV rays because of a possible photosensitization of skin.

Side effects:

Hypersensitivity reactions, photosensitization, nausea, vomiting and other dispeptic phenomena, headache, dizziness, drowsiness, changes of hematologic and biochemical indicators are seldom possible.
Very seldom – allergic reactions (a skin itch and rash).

Interaction with other medicines:

At the concomitant use of norfloxacin and antiacid means or drugs containing iron, zinc, magnesium, calcium or сукралфат norfloxacin absorption decreases (the interval between their reception has to be not less than 2 h).
At a concomitant use of norfloxacin with antifungal means (such as Amphotericinum In, кетоконазол, Miconazolum, nystatin) synergy action is noted.
Norfloxacin can strengthen toxic effect of theophylline and cyclosporine.
At simultaneous use with warfarin it is necessary to control blood coagulation indicators. Probenetsid slows down norfloxacin elimination.

Contraindications:

Pregnancy, lactation, children's and teenage age (up to 15 years), deficit glyukozo-6-fosfatdegidrogenazy, hypersensitivity to norfloxacin and other drugs of a hinolonovy row.

Overdose:

Symptoms (after reception of 3 000 mg in 45 min.): dizziness, nausea, vomiting, drowsiness, emergence of cold sweat (without changes of the main hemodynamic indicators), a convulsive syndrome.
Treatment: a gastric lavage, adequate hydration therapy with an artificial diuresis, purpose of symptomatic means.

Storage conditions:

To store in dry, protected from light and the place, unavailable to children, at a temperature not above 25 °C.
Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

Tablets, coated, on 0,4 g No. 10 in blister strip packagings.