Bacteriophage клебсиелл polyvalent cleared

General characteristics. Structure:

Active ingredients: sterile mix of the cleared filtrates of fagolizat of bacteria of Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.

Excipient: preservative - 8 hydroxyquinolines of sulfate monohydrate - 0,0001 g/ml (in terms of 8 hydroxyquinolines sulfate, contents settlement).

Pharmacological properties:

Pharmacodynamics. Drug causes a specific lysis of bacteria of Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis.

Indications to use:

Treatment and prevention of the diseases caused by bacteria of Klebsiella pneumoniae, Klebsiella ozaenae, Klebsiella rhinoscleromatis as a part of complex therapy:

• ozena, scleroma;
• digestive tract diseases (gastroenterocolitis, cholecystitis, pancreatitis, intestinal dysbiosis);
• inflammatory diseases of newborns and children of early age (gastroenterocolitis, intestinal dysbiosis, omphalitis, pempigus, pyoderma, septicaemia and septicopyemia of various localization);
• surgical infections (suppurations of wounds, purulent damages of skin, burns, peritonitis, pleurisy, mastitis, osteomyelitis, abscess);
• urogenital infections (cystitis, pyelonephritis, urethritis, endometritis, vulvitis, bartholinitis, colpitis, salpingo-oophoritis);
• pyoinflammatory diseases of an ear, throat, nose, bosoms of a nose, oral cavity, throat, throat, bronchial tubes, lungs and pleura (otitis, quinsy, pharyngitis, laryngitis, stomatitis, periodontal disease, antritis, frontal sinusitis, bronchitis, pneumonia, pleurisy);
• posttraumatic conjunctivitis, keratoconjunctivitis, purulent helcoma and iridocyclitis;
• prevention of the intrahospital infections caused by klebsiyella.

Important condition of an effective phagotherapy is preliminary definition of a phagosensitivity of the activator.

Route of administration and doses:

Drug is used for intake (through a mouth), in the form of enemas, applications, irrigations, by introductions to cavities of wounds, vaginas, a uterus, a nose, nose bosoms, and also in the trained cavities: abscesses, belly, pleural, bladder, renal pelvis.

Inside drug is accepted on an empty stomach in 0,5-1 hour prior to meal.

Treatment of pyoinflammatory diseases with the localized defeats has to be carried out at the same time as locally, and administration of drug inside.

In case of processing of a cavity of a suppurative focus chemical antiseptic agents before use of a bacteriophage it has to be washed out sterile 0,9% by chloride sodium solution.

At treatment of an ozena and scleroma drug is used for washing of a nasal cavity and a mucous membrane of upper respiratory tracts, for introduction to cavities of bosoms of a nose (according to clinical indications), and also at damage of a throat, throat, trachea in the form of inhalations (without heating and use of ultrasound).

Drug dose for processing of a mucous nose and upper respiratory tracts of 10-20 ml. After washing mucous in turn in each nasal course enter the turundas moistened with drug into a nasal cavity and leave for 1 hour. The procedure is repeated by 2-3 times a day within 20-40 days.

As the ozena and a scleroma are chronic diseases, for the purpose of prevention of aggravations it is recommended to treat 20-40 day according to the above-stated scheme once a year.

At treatment of quinsies, pharyngitises, laryngitis drug 3 times a day on 10-20 ml use for rinsings of an oral cavity and throat, a course of treatment of 7-10 days.

At treatment of bronchitis, pneumonia drug is accepted inside by 3 times a day on 10-20 ml, and also apply in the form of aerosols and inhalations (without heating and use of ultrasound), a course of treatment of 15-20 days.

At treatment of otitises drug is used for washing and introduction to a tympanic cavity on 2-5 ml by 1-3 times a day. Course of treatment of 7-15 days.

At treatment of inflammations of bosoms of a nose drug is used for washing of a nasal cavity, a nasopharynx and bosoms of a nose in a dose of 5-10 ml and by introductions to bosoms of 2-3 ml. The procedure is repeated daily once within 7-10 days. Besides, the drug is administered in a nasal cavity in the form of the turundas moistened with a bacteriophage in turn in each nasal course and left within 0,5-1 hours. The procedure 3 times a day repeat, a course of treatment of 7-15 days.

At treatment of stomatitises and chronic parodontit drug 3-4 times a day in a dose use in the form of rinsings of an oral cavity 10-20 ml, and also introduction to parodontal-ny pockets of the turundas impregnated with a bacteriophage клебсиелл for 5-10 min., a course of treatment of 7-10 days.

At conjunctivitis and keratoconjunctivites drug is used on 2-3 drops of 4-5 times a day, a course of treatment of 5-7 days; at a purulent helcoma – on 4-5 drops a day within 7-10 days; at purulent iridocyclites – on 6-8 drops each 3 hours in combination with intake in therapeutic dosages within 7-10 days.

At abscesses after opening and removal of purulent contents the drug is administered in quantity smaller, than the volume of remote pus daily once, a course of treatment of 7-10 days.

At peritonitises and pleurisy the drug is administered in the trained cavities – belly and pleural through drainage tubes daily once 20-70 ml, a course of treatment of 10-15 days.

At osteomyelites the drug is administered in a wound cavity through turundas, drainages in number of 10-30 ml daily once, a course of treatment of 15-20 days.

At treatment of suppurations of wounds drug is used in the form of irrigation, applications, bandages, by introductions to a drainage in a dose of 5-50 ml depending on the defeat center not less once a day, a course of treatment of 10-15 days.

At treatment of pyoinflammatory gynecologic diseases (suppurations of wounds, endometritises, vulvit, bartholinites, colpitises, salpingo-oophorites) drug is used for irrigations, applications, enter into cavities of wounds, vaginas, a uterus 5-20 ml within 7-10 days once a day.

At cystitis, pyelonephritises, uretrita drug is accepted inside in a therapeutic dose by 3 times a day in 1 hour prior to food within 10-20 days. If the cavity of a bladder or a renal pelvis are trained, the drug is administered through tsistosty or nefrosty 1-3 once a day on 20-50 ml in a bladder and 5-7 ml in a renal pelvis, a course of treatment of 7-15 days.

At gastoenterokolita, pancreatitis, cholecystitises, and also intestinal dysbioses the bacteriophage is accepted inside in age dosages by 3 times a day in 1 hour prior to food within 7-15 days (according to clinical indications).

At pernicious vomiting drug is used in the form of high enemas by 2-3 times a day on 20-40 ml. At an intestinal dysbiosis drug can be used with drugs normoflor.

For prevention of intrahospital surgical infections drug use for processing of postoperative and svezheinfitsirovanny wounds in a dose 5-50 ml depending on the defeat center daily once within 5-7 days.

Use of drug for children till 1 year (including premature children). At a gastoenterokolita, pneumonia and sepsis of newborns drug is used through a mouth by 2-3 times a day on 3-5 ml in 30 minutes prior to feeding.

In cases of pernicious vomiting drug is used in the form of high enemas (through a colonic tube or a catheter) daily once in a dose of 5-10 ml.

The combination rectal (in the form of high enemas) and oral administration of drug is possible. A course of treatment of 7-15 days (according to clinical indications).

At the recurrent course of a disease perhaps repeated carrying out courses of treatment.

For the purpose of prevention of developing of an intrahospital infection at newborn children the bacteriophage is applied according to epidemic indications inside on 3-5 ml by 3 times a day in 30 minutes prior to feeding during all term of stay in a hospital.

At treatment of omphalites, pyodermas, contaminated wounds the bacteriophage is applied in the form of applications on 5-10 ml by 2-3 times a day (the gauze napkin is moistened with a bacteriophage and impose on an umbilical wound or an affected area of skin) within 7-15 days.  

Use of drug does not exclude use of other antibacterial and antiinflammatory drugs.

Features of use:

Before use the bottle with a bacteriophage needs to be shaken up and seen. Drug has to be transparent and not contain a deposit.

Attention! At opacification not to use drug!

Owing to the content in drug of a medium in which bacteria from the environment can develop, causing drug opacification, it is necessary to follow the following rules when opening a bottle:

• to carefully wash hands;
• to process a cap alcohol-containing solution;
• to remove a cap, without opening a stopper;
• not to put a stopper an internal surface on a table or other objects;
• not to leave a bottle open;
• to store the opened bottle only in the refrigerator.

When using small doses (2-8 drops) drug needs to be selected the sterile syringe of 0,5-1 ml.

Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Use at pregnancy and during breastfeeding. Use of this drug at pregnancy and during feeding by a breast perhaps in the presence of the infections caused by fagochuvstvitelny strains клебсиелл (according to the recommendation of the doctor).

Side effects:

Are not established.

Interaction with other medicines:

Use of drug is possible in combination with other medicines, including with antibiotics.

Contraindications:

Hypersensitivity to drug components.

Storage conditions:

Period of validity - 2 years. In the dry, protected from light place, at a temperature of 2-10 °C. To store in the place, unavailable to children. To store the opened bottle only in the refrigerator. Drug from the opened bottle at observance of storage conditions, above-mentioned rules and lack of opacification can be used during all period of validity.

Issue conditions:

Without recipe

Packaging:

Solution for intake, topical and external use in bottles on 10 or 20 ml. On 4 or 10 bottles with the application instruction in a pack from a cardboard. On 4 bottles in a blister strip packaging from a film polyvinyl chloride. On 1 blister strip packaging with the application instruction in a pack from a cardboard.