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medicalmeds.eu Medicines Antibiotic. Levomycetinum

Levomycetinum

Препарат Левомицетин. ЗАО "Фармацевтическая фирма "ЛЕККО" Россия


Producer: CJSC Pharmaceutical Firm LEKKO Russia

Code of automatic telephone exchange: S01AA01

Release form: Liquid dosage forms. Drops are eye.

Indications to use: Infectious diseases of eyes. Conjunctivitis. Keratitis. Blepharitis. Blefarokonjyunktivit. Keratoconjunctivitis. Neuroparalytic keratitis.


General characteristics. Structure:

Active ingredient: chloramphenicol – 2,5 mg.

Excipients: boric acid – 20 mg, the water purified – to 1 ml.
Description: the transparent, colourless or slightly painted liquid.



Pharmacological properties:

The bacteriostatic antibiotic of a broad spectrum of activity, breaks synthesis of protein in a microbic cell (having fat solubility, gets through a cellular membrane of bacteria and reversibly contacts subunit 50S of bacterial ribosomes in which movement of amino acids to the growing peptide chains is late that leads to disturbance of synthesis of protein). It is effective concerning strains of the bacteria steady against penicillin, tetracyclines, streptocides. Chlamydia trachomatis, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, some types of Enterobacter and Neisseria, Staphylococcus aureus, Streptococcus spp is active concerning Neisseria gonorrhoeae. (including Streptococcus pneumoniae, Streptococcus haemolyticus), Moraxella lacunata, rickettsiae and mycoplasmas.
It is inefficient concerning acid resisting bacteria, anaerobe bacterias, Acinetobacter spp., Serratia marcescens.
 
Pharmacokinetics. At instillation of drug in a conjunctival sac therapeutic concentration of chloramphenicol are created in a vitreous, a cornea, an iris of the eye, watery moisture of an eye; drug does not get into a crystalline lens. Partially gets to a system blood stream. It is removed generally with urine, mainly in the form of inactive metabolites; partially with bile and a stake.

Indications to use:

The bacterial infections of an eye caused by sensitive microflora: conjunctivitis, a keratitis, a blepharitis, blefarokonjyunktivit, a keratoconjunctivitis, a neuroparalytic keratitis in the presence of a consecutive bacterial infection.


Route of administration and doses:

Locally. To adults and children dig in in a conjunctival sac on 1 drop 3-4 times a day. Drug is used by no more than 10 days. Extension of a course of treatment is possible only on doctor's orders.


Features of use:

There are separate data on development of a hypoplasia of marrow after use of ophthalmologic forms (in the course of treatment systematic control of a picture of peripheral blood is necessary).
Influence on ability to control of mechanisms and vehicles: there are no data.

Side effects:

Development of local allergic reactions is possible.
At prolonged use:
 - reticulocytopenia;
 - leukopenia;
 - granulocytopenia;
 - thrombocytopenia;
 - erythrocytopenia;
 - aplastic anemia;
 - agranulocytosis;
 - consecutive fungal infection.

Interaction with other medicines:

Simultaneous use with the medicines oppressing a hemopoiesis (streptocides, cytostatics), influencing a metabolism in a liver; with radiation therapy increases risk of development of side effect. At simultaneous use with erythromycin, clindamycin, lincomycin mutual weakening of action is noted because chloramphenicol can interfere with their linkng with subunit 50S of bacterial ribosomes. Reduces antibacterial effect of penicillin and cephalosporins.


Contraindications:

Levomycetinum is contraindicated at hypersensitivity to chloramphenicol, a tiamfenikol, an azidamfenikol, oppression of a marrowy hemopoiesis, acute intermittent porphyria, deficit glyukozo-6-fosfatdegidrogenazy, a renal and/or liver failure, pregnancy, in the period of a lactation, in the period of a neonatality (to 4 weeks).


Overdose:

Data on overdose of drug are absent.


Storage conditions:

In the cool, protected from light place. To store in places unavailable to children.
Period of validity: 2 years. After opening of a bottle to use solution within 30 days.
Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe


Packaging:

Drops eye 0,25 %. On 5 ml or 10 ml in a bottle - droppers polymeric with a screw mouth, a stopper dropper and the screwed cover with control of the first opening. 1 bottle dropper polymeric together with the application instruction is placed in a pack from a cardboard.



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