Timadren

General characteristics. Structure:

Active agent: Timololum (in the form of a maleate) 2.5 mg

Excipients: a benzalkoniya chloride (preservative), sodium phosphate monosubstituted anhydrous, sodium phosphate disubstituted anhydrous, sodium chloride, water for and.

Active agent: Timololum (in the form of a maleate) 5 mg

Excipients: a benzalkoniya chloride (preservative), sodium phosphate monosubstituted anhydrous, sodium phosphate disubstituted anhydrous, sodium chloride, water for and.

Pharmacological properties:

Non-selective beta adrenoblocker without sympathomimetic activity. At topical administration lowers intraocular pressure due to reduction of formation of watery moisture and small increase in its outflow. Action is shown in 20 min. after an instillation, the maximum effect - in 1-2 h, action duration - 24 h.

Pharmacokinetics. Absorption. Timololum the maleate quickly gets through a cornea into eye tissues.

Distribution. In insignificant quantity gets to a system blood stream by absorption through a conjunctiva, mucous membranes of a nose and the lacrimal path.

Removal. Metabolites are removed by kidneys.

Pharmacokinetics in special clinical cases. At newborns and children of younger age concentration of active agent significantly exceeds its Cmax in a blood plasma of adults.

Indications to use:

— open angle glaucoma;
— closed-angle glaucoma (in a combination from miotika);
— secondary glaucoma (uveal, afakichesky, posttraumatic);
— acute increase in intraocular tension.

Route of administration and doses:

To adults and children 1 years are more senior dig in in a conjunctival sac on 1 drop 0.25% of solution of 2 times/days, at insufficient efficiency - on 1 drop of 0.5% of solution of 2 times/days. At normalization of intraocular pressure a maintenance dose - 1 drop of 0.25% of 1 times/days.

Features of use:

Control of efficiency should be carried out approximately in 3-4 weeks after the beginning of therapy. During treatment at least 1 time in 6 months it is necessary to control function of a slezootdeleniye, integrity of a cornea, field of vision.
At prolonged use of Timololum easing of effect is possible.
It is not necessary to dig in in eyes two beta adrenoblockers at the same time.
At transfer of patients into treatment with Timololum correction of a refraction can be necessary.
Contact lenses should be removed before an instillation and to put on not earlier than in 15 min. after it.
It is necessary to stop Timadren's reception for 48 h before the forthcoming operative measure using the general anesthesia.

Influence on ability to driving of motor transport and to control of mechanisms
It is recommended to be careful when driving the car at night.

Side effects:

From respiratory system: asthma, bronchospasm, pulmonary insufficiency.

From the alimentary system: nausea, vomiting, diarrhea.

From TsNS and peripheral nervous system: dizziness, headache, drowsiness, hallucinations, depression, paresthesias, muscular weakness, disturbance of sexual functions, decrease in a potentiality, passing disturbance of cerebral circulation, collapse, rhinitis, nose congestion, nasal bleeding.

From cardiovascular system: decrease in the ABP, bradycardia, bradyarrhythmia, AV blockade, heart failure, cardiac standstill.

From an organ of sight: a dermahemia a century, burning and an itch in eyes, a conjunctiva hyperemia, dacryagogue or reduction of a slezootdeleniye, a photophobia, cornea epithelium hypostasis, short-term disturbance of visual acuity; a blepharitis, conjunctivitis, at prolonged use development of a superficial dot keratopathy (reduction of transparency of a cornea) and decrease in sensitivity of a cornea is possible, the ptosis is possible; seldom - a diplopia.

Allergic reactions: including small tortoiseshell.

Interaction with other medicines:

Epinephrinum, Pilocarpinum, system beta adrenoblockers strengthen Timadren's action.

At Timadren's use with Reserpinum development of the expressed bradycardia or arterial hypotension is possible (careful medical control is necessary).

At Timadren's use with blockers of calcium channels, cardiac glycosides - AV conductivity disturbance, an acute left ventricular failure or arterial hypotension is possible.

Timololum strengthens action of muscle relaxants (Timadren it is necessary to cancel for 48 h before alleged carrying out the general anesthesia with use of peripheral muscle relaxants).

Contraindications:

— bronchial asthma;
— sinus bradycardia;
— AV blockade of II and III degrees;
— acute and chronic heart failure;
— cardiogenic shock;
— dystrophic diseases of a cornea;
— rhinitis;
— hypersensitivity to drug components.

With care apply at newborn and premature children; at emphysema of lungs, pulmonary insufficiency, cerebrovascular insufficiency, chronic heart failure, a diabetes mellitus, a hypoglycemia, a thyrotoxicosis, a myasthenia, co-administration of other beta adrenoblockers.

Use of the drug TIMADREN® at pregnancy and feeding by a breast
Use of drug at pregnancy is possible only in that case when the estimated advantage for mother surpasses potential risk for a fruit.
In need of use of drug in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

Overdose:

At topical administration in the recommended dose symptoms of overdose were not noted.
Symptoms at accidentally intake: nausea, vomiting, dizziness, headache, decrease in the ABP, bronchospasm, bradycardia.

Treatment: symptomatic. To elimination of the expressed bradycardia or a bronchospasm apply изопреналин in/in, to treatment of arterial hypotension - Dobutaminum.

Storage conditions:

List B. To store in the place, unavailable to children, at a temperature from 15 °C to 25 °C.

Issue conditions:

According to the recipe

Packaging:

Drops eye 0.5%: фл. 5 ml 

Drops eye 0.25%: фл. 5 ml.