Glautam

General characteristics. Structure:

Active ingredient: 3,25 mg of Timololum of a maleate (an equivalent of 2,5 mg of Timololum) in 1 ml of solution.

Excipients: a benzalkoniya chloride, sodium dihydrogen phosphate a dihydrate, sodium hydrogen phosphate anhydrous, water for injections.

Pharmacological properties:

Pharmacodynamics. Non-selective beta adrenoblocker. At topical administration in ophthalmology reduces both the normal, and increased intraocular pressure due to reduction of formation of intraocular liquid and improvement of its outflow, does not exert impact on accommodation and the size of a pupil.

Has anti-anginal, hypotensive and antiarrhytmic effects which are shown at system use. Reduces automatism of a sinus node, urezhat ChSS, slows down AV conductivity, reduces contractility and the need of a myocardium for oxygen.

Pharmacokinetics. At topical administration quickly gets through a cornea, in insignificant quantity gets to a system blood stream due to absorption through conjunctiva vessels, mucous membranes of a nose and the lacrimal path.

Indications to use:

For use in ophthalmology: increase in intraocular pressure, a chronic open angle glaucoma, closed-angle glaucoma (as an additional tool in combination with miotika), secondary glaucoma (including afakichesky), inborn glaucoma (at inefficiency of other therapeutic actions).

Route of administration and doses:

To adults and children 1 years are more senior dig in in conjunctival a bag on 1 drop of 2,5 mg/ml of solution 2 times a day, at insufficient efficiency - on 1 drop of 5 mg/ml of solution 2 times a day. At normalization of intraocular pressure a maintenance dose - 1 drop of 2,5 mg/ml once a day.

Features of use:

Control of efficiency should be carried out approximately in 3-4 weeks after the beginning of therapy. During treatment at least 1 time in 6 months it is necessary to control function of a slezootdeleniye, integrity of a cornea, field of vision.

It is worth being careful when driving the car at night.

Contact lenses should be removed before an instillation and to dress not earlier than in 15 minutes after an instillation.

It is not necessary to dig in in eyes 2 beta adrenoblockers at the same time.

At prolonged use of Timololum easing of effect is possible.

At transfer of patients into treatment with Timololum correction of a refraction can be necessary.

Before the forthcoming operative measure using the general anesthesia - in 48 hours to cancel drug.

At pregnancy drug is used if the expected advantage for mother exceeds potential risk of a fruit. During drug use gudny feeding should be stopped.

Side effects:

From an organ of sight: at topical administration the irritation and a hyperemia of a conjunctiva, skin a century, burning and an itch in eyes, dacryagogue, a photophobia, cornea epithelium hypostasis, a dot superficial keratopathy, a cornea hypesthesia, a diplopia, a ptosis, a xerophthalmus are possible. When carrying out fistuliziruyushchy antiglaukomny operations development of amotio of a retina in the postoperative period is possible.

At system use heart failure, bradycardia, AV blockade, arterial hypotension are possible; headache, sleep disorders, dreadful dreams, adynamy, excitement, depression, paresthesias and cold snap of extremities; nausea, vomiting, diarrhea; asthma, bronchospasm; muscular weakness; skin allergic reactions, exacerbation of psoriasis, dryness of a conjunctiva.

Interaction with other medicines:

Epinephrinum, Pilocarpinum, system beta adrenoblockers strengthen action.

At use with Reserpinum - development of the expressed bradycardia or hypotonia is possible (this combination demands careful medical control); with blockers of calcium channels or cardiac glycosides - disturbance of AV of conductivity, an acute left ventricular failure or arterial hypotonia is possible.

Strengthens action of muscle relaxants (тимомлол it is necessary to cancel in 48 hours prior to alleged administration of the general anesthesia with use of peripheral muscle relaxants).

It is impossible to apply at the same time with antipsychotic HP (neuroleptics) and anxiolytic HP (tranquilizers).

During treatment it is not recommended to accept ethanol (perhaps sharp snizhny arterial pressure)

Contraindications:

AV blockade of II and III degrees, sinuatrial blockade, bradycardia, SSSU, arterial hypotension, chronic heart failure of IIB-III of a stage, acute heart failure, vasculomotor rhinitis, Raynaud's disease and other obliterating diseases of vessels, metabolic acidosis, lactation, hypersensitivity to drug.

With care. Emphysema of lungs, pulmonary insufficiency, cerebrovascular insufficiency, chronic heart failure, diabetes mellitus, hypoglycemia, thyrotoxicosis, myasthenia, simultaneous nakhnacheniye of other beta adrenoblockers.

Overdose:

At topical administration in the recommended doses symptoms of overdose were not noted. At accidental intake development of the following symptoms is possible: nausea, vomiting, dizziness, headaches, lowering of arterial pressure, bronchospasm, brazhikardiya. In case of development of symptoms of overdose a symptomatic treatment. Izoprenalin it is possible to enter intravenously for elimination of the expressed bradycardia or a bronchospasm, Dobutaminum for treatment of hypotension.

Storage conditions:

Period of validity - 2 years. After opening of a bottle - 6 weeks. Not to apply on expiry date. List B. At a temperature not above 25 °C, in densely corked bottle, in protected from light and children places.

Issue conditions:

According to the recipe

Packaging:

On 5 ml of solution in a transparent polyethylene (LDPE, HDPE) bottle dropper with a polyethylene (HDPE) cover of white color. One bottle together with the instruction is placed in a cardboard pack.