Askoril Ekspektorant

General characteristics. Structure:

Active agents: salbutamol the sulfate equivalent to salbutamol – 2,00 mg, Bromhexine a hydrochloride – 4,00 mg, гвайфенезин – 100,00 mg;

Excipients: sucrose (sugar), sorbitol (70% solution), глицерол (glycerin), propylene glycol, Natrium benzoicum, lemon monohydrate of acid, sorbic acid, dye a sunset yellow (FCF), menthol (left menthol), fragrance blackcurrant (a fragrance ID 20158 blackcurrant), fragrance pineapple (a fragrance pineapple super "RN"), the water purified.

Pharmacological properties:

The combined drug, has broncholitic, expectorant and mucolytic effect. Salbutamol - broncholitic means, stimulates beta2-adrenoceptors of bronchial tubes, blood vessels and a myometrium. Warns or eliminates a spasm of bronchial tubes, reduces resistance in respiratory tracts, increases the vital capacity of lungs. Causes expansion of coronary arteries, does not reduce arterial pressure. Bromhexine - mucolytic means. Has expectorant effect, improves otkhozhdeny phlegms. Gvayfenezin - mucolytic means, reduces surface intention of structures of the bronchopulmonary device; stimulates the secretory cells of a mucous membrane of bronchial tubes producing neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces viscosity of a phlegm, facilitates removal of a phlegm and promotes transition of unproductive cough to productive.

Pharmacokinetics. Salbutamol: at intake absorption - high. Meal reduces absorption speed, but does not influence bioavailability. Communication with proteins of plasma - 10%. Gets through a placenta.
Is exposed to presistemny metabolism in a liver and in an intestinal wall, by means of a fenolsulfotransferaza it is inactivated to ether 4-o-sulfate. An elimination half-life (T1/2) - 3.8-6 h. It is removed by kidneys (69-90%), it is preferential in the form of an inactive fenolsulfatny metabolite (60%) during 72 h and with bile (4%). Bioavailability of the salbutamol entered orally makes about 50%.
Bromhexine: At intake almost completely (99%) it is soaked up in the gastro intestinal path (GIP) within 30 min. Bioavailability - low (effect of primary "passing" through a liver). Gets through placental and hematoencephalic barriers. In a liver is exposed to demethylation and oxidation, it is metabolized to pharmacological active Ambroxol. T1/2 - 15 h (owing to slow return diffusion from fabrics). It is removed by kidneys. At a chronic renal failure removal of metabolites is broken. At repeated use can kumulirovat.
Gvayfenezin: absorption from a GIT - bystry (in 25-30 min. after intake). T1/2 - 1 h. Gets into the fabrics containing acid mucopolysaccharides. About 60% of the administered drug are exposed to metabolism in a liver. It is removed by lungs (with a phlegm) and kidneys both in an invariable look, and in the form of inactive metabolites.

Indications to use:

As a part of a combination therapy of the acute and chronic bronchopulmonary diseases which are followed by formation of difficult separated viscous secret:
- bronchial asthma;
- tracheobronchitis;
- obstructive bronchitis;
- pneumonia;
- emphysema of lungs;
- whooping cough;
- pneumoconiosis;
- pulmonary tuberculosis, etc.

Route of administration and doses:

Inside. To adults and children 12 years are more senior appoint 10 ml (2 teaspoons) 3 times/days. To children under 6 years - on 5 ml (1 teaspoon) 3 times/days, from 6 to 12 years - on 5-10 ml (1-2 teaspoons) 3 times/days.

Features of use:

There are no data.

Side effects:

Seldom: at use in high doses the headache, dizziness, the increased nervous irritability, a sleep disorder, drowsiness, a tremor, spasms, nausea, vomiting, diarrhea, an aggravation of a peptic ulcer of a stomach and duodenum, a cardiopalmus are sometimes observed, coloring of urine in pink color, allergic reactions (rash, urticaria), a collapse, a bronchospasm is possible.

Interaction with other medicines:

Other beta2-adrenomimetichesky means and theophylline strengthen effect of salbutamol and increase probability of emergence of side effects.
Askoril an ekspektorant do not appoint along with the drugs containing codeine and other antibechics as it complicates an otkhozhdeniye of the liquefied phlegm.
Askoril who is a part of drug an ekspektorant Bromhexine promotes penetration of antibiotics (erythromycin, cefalexin, Oxytetracyclinum) into pulmonary fabric.
Askoril an ekspektorant along with non-selective blockers of beta adrenoceptors, such as propranolol is not recommended to use drug.
Askoril who is a part of drug an ekspektorant salbutamol is not recommended to patients who receive monoamine oxidase inhibitors (MAO).
Diuretics and drugs of glucocorticosteroids strengthen gipokaliyemichesky effect of Salbutamol.
The ekspektorant is not recommended to accept along with Askoril alkaline drink.

Contraindications:

- hypersensitivity to drug components;
- pregnancy, lactation period;
- tachyarrhythmia, myocarditis;
- heart diseases;
- dekompensirovanny diabetes mellitus;
- thyrotoxicosis;
- glaucoma;
- liver or renal failure;
- a peptic ulcer of a stomach and duodenum in an aggravation stage.

With care
Diabetes mellitus, arterial hypertension, peptic ulcer of a stomach and duodenum in a remission stage.

Pregnancy and lactation
Drug is contraindicated during pregnancy and a lactation.

Overdose:

Symptoms: strengthening of manifestations of side effects, except for dozonezavisimy allergic reactions.
Treatment: symptomatic therapy.

Storage conditions:

List B.
In the dry, protected from light place at a temperature above 25 °C are not higher.
To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Syrup.
On 100 ml or 200 ml in a plastic bottle of dark color with the screw-on aluminum cover with control of the first opening on which the plastic measured cap of white color is fixed. Each bottle together with the application instruction is placed in a cardboard pack.