Azmaril

General characteristics. Structure:

Active ingredients: 2 mg of salbutamol of sulfate are equivalent salbutamol, 4 mg of Bromhexine of a hydrochloride, 100 mg of a gvayfenezin, 1 mg of menthol in 10 ml of syrup.

Excipients: propylene glycol, aspartame (E 951), Natrium benzoicum (Е 211), citric acid, monohydrate, sodium citrate, "yellow decline" dye (Е 110), fragrance pineapple, the gidroksipropilmetiltsellyuloza, water purified.

Pharmacological properties:

Pharmacodynamics. Azmaril – the combined drug, has broncholitic, expectorant and mucolytic effect. Thanks to a rational combination of salbutamol, Bromhexine of a hydrochloride, a gvayfenezin and menthol effectively and quickly reduces expressiveness of functional disturbances from respiratory system.

Salbutamol – broncholitic means, a stimulator β2-адренорецепторов bronchial tubes. Warns or eliminates a spasm of bronchial tubes, reduces resistance in respiratory tracts. Prevents allocation of mediators of an allergy and an inflammation from mast cells. Improves mukotsiliarny clearance.

Bromhexine – mucolytic means with expectorant and antibechic action. Increases a serous component of a bronchial secret, activates a ciliary epithelium, reduces viscosity of a phlegm, increases its volume and facilitates removal.

Gvayfenezin – mucolytic means. Stimulates secretory cells of a mucous membrane of bronchial tubes which produce neutral polysaccharides, it is depolymerized acid mucopolysaccharides, reduces viscosity of a phlegm, activates tsiliarny the device of bronchial tubes, promotes transition of unproductive cough to productive, facilitates removal of a phlegm.

Menthol reduces hypostasis of a mucous membrane of bronchial tubes and facilitates health.

Pharmacokinetics. It was not studied.

Indications to use:

Symptomatic treatment of respiratory diseases which are followed by cough, a bronchospasm.

Route of administration and doses:

To adults and children 12 years are more senior: 2 teaspoons (10 ml) of syrup 3 times a day. The maximum daily dose – 30 ml.

To children aged from 6 up to 12 years: 1 teaspoon (5 ml) of syrup 2-3 times a day. The maximum daily dose – 15 ml.

To children aged from 3 up to 6 years: 1 teaspoon (5 ml) of syrup 2 times a day. The maximum daily dose – 10 ml.

Treatment duration – 5-10 days.

Features of use:

Use during pregnancy or feeding by a breast. Salbutamol gets into breast milk therefore it is contraindicated to use drug during feeding by a breast. To pregnant women drug is appointed only if the expected advantage for mother exceeds any possible risk for a fruit.

Children. Drug is not used to children age up to 3 years.

Features of use. Drug with care is used at diseases of cardiovascular system. Azmaril patients should appoint with extra care with hypersensitivity to sympathomimetics.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Considering that at Azmarilu's use can arise tachycardia, a tremor of hands, muscular spasms for the period of administration of drug it is necessary to refrain from control of vehicles and work with mechanisms.

Side effects:

From the alimentary system: nausea, vomiting, dryness in a mouth.

From the central nervous system: headache, dizziness, excitement, tremor of hands.

From respiratory system: paradoxical bronchospasm.

From cardiovascular system: arrhythmia, tachycardia.

Others: hyperglycemia, hypopotassemia, perspiration, allergic reactions.

Interaction with other medicines:

Simultaneous use of drug with sympathomimetics is not recommended as the risk of development of side effects from cardiovascular system increases. Expressiveness of therapeutic effect of salbutamol can be reduced in case of simultaneous use with blockers of β-adrenoceptors..........

Salbutamol is incompatible with non-selective β-adrenoblockers.......... Simultaneous use of salbutamol with MAO inhibitors and tricyclic antidepressants through risk of a sharp lowering of arterial pressure is not allowed. The levodopa strengthens probability of developing of arrhythmias. Bromhexine improves penetration of antibiotics in pulmonary fabric. Salbutamol exponentiates toxic effects of ephedrine and theophylline, increases risk of glikozidny intoxication, reduces anti-anginal effect of nitrates. Diuretics and corticosteroids strengthen gipokaliyemichesky effect of salbutamol.

Contraindications:

Hypersensitivity to any of drug components, a diabetes mellitus, a peptic ulcer of a stomach and/or duodenum, arterial hypertension, the expressed abnormal liver functions and/or kidneys, a hyperthyroidism, a pheochromocytoma, heart failure, arrhythmia, І a pregnancy trimester, children's age up to 3 years.

Overdose:

Symptoms: dizziness, nausea, vomiting, tachycardia, arrhythmia, lowering of arterial pressure, hypopotassemia, excitement, psychotic reactions.

Treatment. Symptomatic therapy.

Storage conditions:

Period of validity - 2 years. Not to use drug after the termination of the period of validity specified on packaging. To store in the dry, dark place at a temperature not above 25 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

On 100 ml of syrup in a bottle. On 1 bottle in a cardboard box.