Йодтирокс

General characteristics. Structure:

Active components: left thyroxine sodium - 0,100 mg and potassium iodide - 0,131mg, Excipients: microcrystallic cellulose, gelatin, croscarmellose sodium, magnesium сгеарат

Description

Almost white, round, flat on both sides of a tablet with slanted edge, a dividing notch on the one hand and an engraving "I eat 45" with another.

Pharmacological properties:

Йодтирокс® - the combined drug containing synthetic hormone of a thyroid gland left thyroxine (14) and iodine in the form of potassium iodide which is a structural element in synthesis of hormones of a thyroid gland (thyroxine and triiodothyronine) Drug fills shortage of hormones of a thyroid gland. Increases the need of fabrics for oxygen, stimulates their growth and a differentiation, increases the level of basal metabolism (proteins, fats and carbohydrates), In small doses renders anabolic, and in big - catabolic effect. Oppresses production of thyritropic hormone Strengthens power processes, exerts positive impact on functions of nervous and cardiovascular systems, a liver and kidneys Compensates for the iodine deficiency of an organism.

Indications to use:

• Hypothyroidism
• the euthyroid craw connected with a lack of iodine of an organism at children, teenagers and adults including during pregnancy;
• prevention of a recurrence of a craw after a resection of a thyroid gland,
• thyrotoxicosis of any genesis;
• autonomous adenomas of a thyroid gland: - an acute myocardial infarction, acute myocarditis; - not treated insufficiency of bark of adrenal glands; - herpetiform dermatitis of Dyuringa.

Route of administration and doses:

The daily dose is defined by the doctor individually depending on indications. The daily dose of the drug Yodtiroks® is accepted once a day in the morning, on an empty stomach, in 30 minutes prior to a breakfast, washing down a tablet with a small amount of liquid and not chewing. Babies a daily dose of the drug Yodtiroks® are given in 1 reception, having dissolved a tablet in a small amount of water to a thin suspension for half an hour before meal. The following mode of a dosage is recommended:

Initial dose 1/2 tablets of the drug Yodtiroks® a day, After 2-4 weeks increase a dose depending on age, body weights of the patient and portability of drug the Maintenance dose 1 tablet a day during pregnancy 1-/2 tablets a day Duration of reception is established by the doctor and usually makes of several months to lifelong.

Features of use:

Drug is appointed with care the patient with cardiovascular diseases, including an arterial hypertension, stenocardia, heart failure In these cases before purpose of the drug Yodtiroks® should be carried out treatment of a basic disease, Administration of drug of Yodtiroks® is begun with small doses. At development of pains in a thorax or other symptoms testimonial of deterioration in a current of warmly vascular diseases, it is necessary to reduce a drug dose.

Extra care should be observed at purpose of drug the elderly patient Lecheniye at them it is necessary to carry out by lower doses

Use of drug for patients with a diabetes mellitus, not diabetes mellitus or insufficiency of bark of adrenal glands can lead to strengthening of expressiveness of symptoms of these diseases, During this period attentive selection of doses of medicines for treatment of the specified diseases is required

At the hypothyroidism caused by damage of a hypophysis it is necessary to find out whether there is at the same time an insufficiency of bark of adrenal glands, In this case replacement therapy of a glkyuokortikosteroidama should be begun prior to baking of a hypothyroidism with thyroid hormones in order to avoid development of acute adrenal insufficiency At correctly picked up therapeutic dose drug does not exert impact on ability to driving of vehicles and to control of mechanisms.

Side effects:

At hypersensitivity to iodine temperature increase, emergence of rash and erubescence, an itch and burning in eyes, cough is possible, diarrhea or a headache In this case reception of Yodtiroksa® should be stopped

Interaction with other medicines:

Йодтирокс® strengthens effect of indirect anticoagulants that can demand decrease in their dose. At the co-administration of the drug Yodtiroks® and drugs influencing coagulability of blood it is necessary to control indicators of coagulability of blood Thyroid hormones can increase the need for insulin and peroral hypoglycemic drugs. More frequent control of level of glucose of blood is recommended to be carried out to the periods of the beginning of baking by drug, and also at change of its mode of dosing At bystry intravenous administration of Phenytoinum increase in level of free left thyroxine in a blood plasma is possible, at the same time disturbances of a heart rhythm can be observed. Left thyroxine can be forced out from connections with proteins of a blood plasma under the influence of salicylates, a dikumarol, high doses of furosemide (250 mg), Clofibratum and other substances. Use of tricyclic antidepressants with the drug Yodtiroks® can lead to strengthening of effect of antidepressants.

At simultaneous use холестирамин, колестипол and aluminum hydroxide reduce plasma concentration of drug due to braking of absorption it in intestines therefore Yodtiroks® is recommended to be accepted in 4-5 hours prior to reception of these drugs, At simultaneous use with kaliysberegayushchy diuretic drugs of potassium iodide can lead to increase in level of potassium in blood

Йодтирокс® reduces effect of cardiac glycosides

At simultaneous use with anabolic steroids, asparaginase, Tamoxifenum perhaps pharmacokinetic interaction at the level of protein-binding.

At co-administration with estrogen or estrogensoderzhashchy oral contraceptives increase in a dose of the drug Yodtiroks® Somatotropinum can be required at simultaneous use with drug of Yodtiroks can accelerate closing of epiphyseal regions of growth

Reception of phenobarbital, carbamazepine and rifampicin can increase clearance of left thyroxine

and to demand increase in a dose of the drug Yodtiroks®.

Contraindications:

• With care it is necessary to appoint drug at diseases of cardiovascular system: An ischemic heart disease (atherosclerosis, stenocardia, a myocardial infarction in the anamnesis), heart failure, arterial hypertension, tachycardia, a tachyarrhythmia; at a diabetes mellitus, not diabetes mellitus, heavy, it is long the existing hypothyroidism, adrenal insufficiency, a sprue, to patients of advanced age (dose adjustment can be required)

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding therapy by the drug Yodtiroks® appointed concerning a hypothyroidism has to continue At nursing mothers drug has to be applied with care.

Overdose:

At overdose (especially at too bystry increase in a dose in an initiation of treatment) thyrotoxicosis symptoms can be observed: tachycardia, disturbance cordial a rhythm, a tremor of fingers, internal concern, sleeplessness, the increased perspiration, decrease in body weight, diarrhea, In that case it is necessary to lower a dose or to stop administration of drug for several days. After disappearance of side effects treatment should be begun with care with lower dose At acute overdose and intoxication it is recommended to stop administration of drug and to conduct control examination.

Storage conditions:

To store in the dry place at a temperature of 15 - 25 °C in the place, unavailable to children. Period of validity 2 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Form of release of the Tablet On 50 or 100 tablets in a plastic case or on 25 tablets in the blister. On 1 case or 2 or 4 blisters place in a cardboard pack together with the application instruction.