Adzhivita

General characteristics. Structure:

Active ingredient: 300 mg of fish oil from cod liver which part are: 275 ME Retinolums (vitamin A), 27,5 ME cholecalciferols (D3 vitamin).

Excipients: gelatin, glycerin, sorbite solution, methylparaben (Е 218), propylparaben (Е 216), the water purified.

Pharmacological properties:

Pharmacodynamics. Effect of drug is caused by pharmacological properties of its compound.

Omega-3-polinenasyshchennye fatty acids which are a part of fish oil from cod liver reduce the level of triglycerides, lipoproteids of the low density (LPNP) and lipoproteids of very low density (LPONP) in a blood plasma, reduce aggregation of thrombocytes that leads to reduction of viscosity of blood and risk of a thrombogenesis, microcirculation improvement, especially in the vessels affected with atherosclerosis.

Vitamin A (Retinolum) is necessary for full functioning of a retina. In a retina vitamin A is combined with opsin (a red pigment of a mesh cover) that leads to formation of rhodopsin which is necessary for adaptation of sight to darkness. Other forms (Retinolum, a retinolov acid) are necessary for growth of bones, for functioning of testicles and ovaries, for development of an embryo, for regulation of growth and differentiation of epithelial fabrics. Also vitamin A can work as a cofactor in biochemical reactions.

Vitamin D is necessary in processes of absorption and utilization of calcium and phosphate for normal calcification of bones. In combination with parathyroid hormone and a calcitonin vitamin D regulates the level of concentration of calcium and phosphorus in a blood plasma. Vitamin D stimulates absorption of calcium and phosphate from a small intestine and will mobilize calcium from bones.

After internal use omegas-3-polyunsaturated fatty acids are soaked up in a small intestine. Metabolism happens in a liver. After formation of complexes with lipoproteins of blood are transferred in peripheral fat depos. The majority of fatty acids is used for ensuring energy needs of an organism. The elimination half-life makes 18-31 days.

Vitamin A is quickly soaked up from digestive tract (duodenal and thin guts). In the course of absorption of Retinolum bile, a pancreatic lipase, proteins take part.

It is less than 5% of vitamin A which circulates contact blood lipoproteins. The amount of the vitamin A connected with lipoproteins can increase at a giperlipoproteinemiya.

Vitamin A can collect in a liver, in a small amount – in kidneys and tissue of lungs. Zinc promotes mobilization of reserves of vitamin A in a liver.

D3 vitamin is quickly soaked up from a small intestine. The maximum concentration in a blood plasma is reached approximately in 3–6 hour. Vitamin D contacts specific alpha globulins. Collects preferential in a liver and other fat depos.

Metabolism of cholecalciferol happens in two stages: the first – in a liver, the second – in kidneys. Vitamin D with bile and with urine is removed.

Indications to use:

Prevention of early atherosclerosis of vessels,

Prevention and treatment of a hypovitaminosis of vitamins A and D.

Route of administration and doses:

Drug is used inside after food. For the purpose of prevention of early atherosclerosis by the adult about 1 capsule 3 times a day courses not less than 2 months is recommended to apply.

For prevention of a hypovitaminosis by the adult and to children 14 years are more senior appoint on 1 capsule 3 times a day within 1-2 months. To children aged from 7 up to 14 years – on 1 capsule 2 times a day within 1 month (a course dose – 60 capsules).

For treatment of a hypovitaminosis at adults and children age of 7 years the recommended dose makes 1 capsule 3 times a day. Duration of use depends on hypovitaminosis degree of manifestation.

Features of use:

With care to apply to patients of advanced age, patients with a long immobilization. In case of simultaneous use with thiazide diuretics it is necessary to control calcium level in blood and urine each 3 - 6 months.

At prolonged use (more than 45 days) it is necessary to control the level of calcium and phosphorus in a blood plasma and urine.

Not to apply along with reception of high doses of calcium.

Drug has property to collect and is long to be in an organism.

Women who accepted high doses of Retinolum can plan pregnancy not earlier than in 6-12 months. It is connected with the fact that during this time there is a risk of maldevelopment of a fruit under the influence of the high content of vitamin A in an organism. It is recommended to stop administration of drug at least in 4 days prior to operation or other surgical interventions.

Use during pregnancy or feeding by a breast. Contraindicated in the first trimester of pregnancy, in the second and third trimester drug is used only in that case when the estimated advantage for mother exceeds potential risk for a fruit. There are no sufficient data concerning use of drug during feeding by a breast.

Ability to influence the speed of reactions at control of motor transport or work with other mechanisms. It is not described, however if the patient has a drowsiness during treatment by drug it is necessary to refrain from control of motor transport and work with other mechanisms.

Children. Considering a dosage form, it is not recommended to apply to children under 7 years. To prevention and treatment of a hypovitaminosis at children under 7 years fish oil is applied in other dosage form.

Side effects:

From the alimentary system: appetite loss, nausea, vomiting, diarrhea.

From immune system: allergic reactions, including skin rashes, itch.

From skin and hypodermic cellulose: xeroderma, skin peeling.

From a nervous system: slackness, irritability, sleep disorder, general weakness, drowsiness, headache.

Laboratory indicators: increase in content of calcium in blood and urine, changes of indicators of urine.

Others: fervescence, disorder of gait, hyperemia of the person, ostealgia of the lower extremities. Formation of calcificats in parenchymatous bodies is possible.

Interaction with other medicines:

Decrease in absorption of vitamin A from digestive tract at use of Adzhivity® with Neomycinum is possible, holestiraminy or liquid paraffin. At simultaneous use of Adzhivity® with synthetic retinoids, such as ацитретин, изотретиноин and третиноин, the risk of development of a hypervitaminosis increases And. At simultaneous use of drug with a clumsy vaccine reduction of its efficiency and increase in frequency of emergence of side effects is possible. Estrogen increases risk of development of a hypervitaminosis And.

Anticonvulsant drugs, rifampicin, холестирамин reduce cholecalciferol absorption.

At simultaneous use of drug with cardiac glycosides the risk of development of disturbances of a cordial rhythm increases.

At simultaneous use of drug with thiazide diuretics development of a hypercalcemia is possible.

Glucocorticosteroids and anticonvulsant drugs reduce efficiency of cholecalciferol.

At combined use with warfarin periodic control of a prothrombin time is recommended.

Contraindications:

Hypersensitivity to drug components, blood coagulation disturbance, hemophilia, a hypervitaminosis of vitamins A and D, a hypercalcemia, acute and chronic nephrite, heart failure in decompensation stages, the first trimester of pregnancy, an urolithiasis with existence of concrements of calcic structure, an idiopathic hypercalcemia, нефроуролітіаз, a hypercalcuria, a calcic nephrolithiasis, a thyrotoxicosis, a pulmonary tuberculosis (an active form), a heavy liver and renal failure, a sarcoidosis, cholelithiasis, chronic pancreatitis.

Overdose:

Symptoms: a headache, nausea, vomiting, a diplopia, dryness of mucous membranes, desquamation, disturbance of structure of bones, demineralization of bones, ostealgias, injuries of a liver, anorexia, a lock, muscle pain, an arthralgia, a hypercalcemia, a hypercalcuria, deposition of calcium in soft tissues that the xeroderma, emergence of a nevus pigmentosus, increase in the sizes of a liver and spleen, jaundice, change of a picture of blood, loss of forces, drowsiness, slackness, temperature increase, a polyuria, depressions, disturbances of mentality, loss of body weight leads to irreversible renal failures and cardiovascular system.

Treatment. Drug withdrawal, a diet with the low content of calcium, the use of a large amount of liquid. Therapy is symptomatic.

Storage conditions:

Period of validity - 3 years. Not to use drug after the termination of the period of validity specified on packaging. To store in original packaging at a temperature not over 25 ºС. To store in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 15 capsules in the blister, on 2 blisters in a cardboard box.