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Acyclovir ointment

Препарат Ацикловира мазь. Stada Arzneimittel ("ШТАДА Арцнаймиттель") Германия


Producer: Stada Arzneimittel ("STADA Artsnaymittel") Germany

Release form: Soft dosage forms. Ointment.

Indications to use: Genital herpes. (Deprive) the surrounding herpes. Chicken pox (Chicken pox).


General characteristics. Structure:

Acting substance: an acyclovir – 5 g and excipients (oil chicken either oil chicken refined food or a component lipidic bird's fat, poly(ethylene oxide) 400, emulsifier No. 1, нипагин, нипазол, the water purified) – to 100 g.




Pharmacological properties:

Antiviral drug – a synthetic analog of a nucleoside of thymidine. In the infected cells containing a virus thymidinekinase there is a phosphorylation and transformation into active connection – an acyclovir triphosphate. Sharp selectivity of action and a hypotoxicity for the person are caused by lack of necessary enzyme for its activation in intact cells of a macroorganism. An acyclovir triphosphate, "being built in" in synthesized by the DNA virus, blocks reproduction of a virus. Specificity and very high selectivity of action is also caused by its preferential accumulation in the cells affected with a herpes virus.

It is highly active concerning a virus of a herpes simplex (Herpes simplex) I and II of type; the virus causing chicken pox and shingles (Varicella zoster); Epstein's virus – Barre (types of viruses are specified in ascending order of acyclovir size MPK). It is moderately active concerning cytomegaloviruses. At herpes prevents formation of new elements of rash, reduces probability of skin dissimination and visceral complications, accelerates formation of crusts, reduces pain in an acute phase of the surrounding herpes. Has an immunopromoting effect.

Pharmacokinetics. At ointment use, the acyclovir is not soaked up in a system blood stream.


Indications to use:

Skin herpes simplex; prevention of the infections caused by a herpes simplex virus in patients with disturbances of immune system; genital herpes (primary and recurrent); shingles; chicken pox.


Route of administration and doses:

Outwardly.
Ointment is applied on affected areas of skin of 5 times a day (as soon as possible after the beginning of an infection). It is important to begin treatment of a recurrent infection during a prodromal phase or at the very beginning of display of an infection. A course of treatment - not less than 5 days, at most 10 days.



Side effects:

In isolated cases emergence of the local irritation of mucous membranes disappearing after drug withdrawal is possible. At prolonged use of ointment certain patients can have a peeling of small sites of skin.



Contraindications:

Hypersensitivity to drug.




Issue conditions:

Without recipe


Packaging:

Acyclovir, ointment on 3, 5 and 10 g in tubas. Each tuba together with the instruction on a medical use is placed in a pack cardboard.



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