Coldrex Hotr lemon and honey

General characteristics. Structure:

Active agents: paracetamol of 600 mg, Phenylephrinum hydrochloride of 10 mg, vitamin C (ascorbic acid) of 40 mg.

Excipients: sucrose, sodium citrate, citric acid, starch corn, sodium cyclomate, sodium saccharinate, fragrance lemon 610399E, fragrance honey 610507E, fragrance honey F7624/P, SCS 36393 E150 caramel.

Pharmacological properties:

Means for elimination of symptoms of ORZ and "cold" (analgeziruyushchy non-narcotic means + α — адреномиметик + vitamin). The combined drug. Paracetamol has the febrifugal and anesthetizing effect. Fenilefrin reduces hypostasis of mucous membranes of a nose and bosoms owing to what breath is facilitated. Ascorbic acid fills the increased need for vitamin C at "catarrhal" diseases and flu.

Indications to use:

Symptoms of "catarrhal" diseases and flu:

• the increased temperature,
• headache,
• fever,
•  joint pain and muscles,
• nose congestion,
•  pharyngalgia and nose bosoms.

Route of administration and doses:

To pour out contents of one bag in a glass. To pour a half of a glass of hot water and it is good to stir. To add cold water at will.

Adults (including elderly) and children are more senior than 12 years: to accept on one bag every 4-6 hours. Not to accept more than 6 bags within 24 hours.

 Do not exceed the specified dosage.

Features of use:

In order to avoid toxic damage of a liver paracetamol should not be combined with reception of alcoholic beverages, and also to accept to the persons who are chronically taking alcohol.

Drug is not recommended to apply more than five days without consultation with the doctor. If symptoms remain, see a doctor.

Reception of paracetamol distorts indicators of laboratory researches at quantitative definition of glucose and uric acid in plasma.

Influence on ability of driving and other mechanisms

As active components of drug do not render sedation, at reception in the recommended doses,   there are no restrictions on driving of the car and work with mechanisms.

Side effects:

Paracetamol seldom has side effect. Allergic reactions are sometimes possible: skin rash, small tortoiseshell, Quincke's disease. Seldom — disturbances of system of blood (thrombocytopenia, a leukopenia, an agranulocytosis). At prolonged use with exceeding of the recommended dose hepatotoxic and nephrotoxic action can be observed.

Phenylephrinum the hydrochloride can make sick, a headache, slight increase of arterial pressure and , in rare instances, heartbeat which pass after drug withdrawal.

In case of undesirable reactions, see a doctor.

Interaction with other medicines:

At reception for a long time paracetamol strengthens effect of indirect anticoagulants (warfarin and other derivatives of coumarin) that increases risk of bleedings. Inductors of enzymes of a microsomal oxidation in a liver (barbiturates, dipheninum, carbamazepine, rifampicin, a zidovudine, Phenytoinum, ethanol, phenylbutazone and tricyclic antidepressants) increase risk of a hepatotoxic action at overdose by paracetamol. Inhibitors of a microsomal oxidation in a liver (Cimetidinum) reduce risk of a hepatotoxic action. Metoclopramidum and домперидон is increased, and Colestyraminum reduces paracetamol absorption speed. Ethanol promotes development of acute pancreatitis. Drug can reduce activity of uricosuric drugs. Antidepressants, protivoparkinsonichesky and antipsychotic means and derivatives of a fenotiazin increase risk of an ischuria, dryness in a mouth, a lock. Glucocorticosteroids increase risk of development of glaucoma. The halothane increases risk of ventricular arrhythmia. Fenilefrin reduces hypotensive effect of a guanetidin. Guanetidin and tricyclic antidepressants strengthen sympathomimetic effects of Phenylephrinum.

Contraindications:

• Hypersensitivity to any component of drug
• Reception of other paratsetamolsoderzhashchy means and means for relief of symptoms of "cold", flu and a congestion of a nose
• The expressed abnormal liver functions and kidneys
• Thyrotoxicosis;
• Diabetes mellitus and deficit dehydrogenase glyukozo-6-phosphate (contains sugar)
• Heart diseases (the expressed stenosis of the mouth of an aorta, an acute myocardial infarction, tachyarrhythmias)
• Arterial hypertension
• Reception of tricyclic antidepressants, beta adrenoblockers, monoaminooxidase inhibitors, including during the period up to 14 days after their cancellation
• Prostate hyperplasia
• Closed-angle glaucoma
• Children's age up to 12 years

With care — high-quality hyperbilirubinemias, pregnancy, the lactation period.

Overdose:

Symptoms. At the overdose caused, as a rule, by paracetamol nausea, vomiting, a stomach ache, perspiration, pallor of integuments are possible. In 12–48 hours signs of an abnormal liver function are defined (increase in activity of "hepatic" transaminases, increase in a prothrombin time, гепатонекроз). Disturbance of exchange of glucose and emergence of a metabolic acidosis is possible. In hard cases are possible: a liver failure with the progressing encephalopathy, a coma and death; an acute renal failure with a tubular necrosis ( including in the absence of severe damage of a liver); arrhythmias, pancreatitis. The hepatotoxic effect at adults is shown at reception of 10 g and more paracetamol.

Treatment. In case of overdose immediately ask for medical care even if you feel well as there is a risk of emergence of the delayed signs of serious injury of a liver.

Within the first 4 hours after overdose the gastric lavage and purpose of adsorbents (absorbent carbon) are effective. Anyway it is necessary to bring the patient to medical institution.

Purpose of antidotes of paracetamol (Acetylcysteinum, methionine) is effective within the first days after overdose: methionine — within 12 hours, Acetylcysteinum —  till 24 o'clock. Carrying out a symptomatic treatment is necessary. Need for holding additional therapeutic actions (further administration of methionine, in/in introduction of N-Acetylcysteinum) is defined depending on concentration of paracetamol in blood, and also from time which passed after its reception.

Storage conditions:

To store at a temperature not over 25 ºС in the place, unavailable to children.

Period of validity - 3 years. Do not use after a period of validity.

Issue conditions:

Without recipe

Packaging:

Powder for preparation of solution for intake.

On 6 g in bags from a laminate: paper / polyethylene of low density / aluminum foil / polyethylene of low density.

5 or 10 bags together with  the application instruction place in a cardboard pack.