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medicalmeds.eu Medicines The means operating on a nervous system. Paratsetamol-Darnitsa, the tab. on 0.2 g No. 10

Paratsetamol-Darnitsa, the tab. on 0.2 g No. 10

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Producer: CJSC Pharmaceutical Firm Darnitsa Ukraine

Code of automatic telephone exchange: N02BE01

Release form: Firm dosage forms. Tablets.

Indications to use: Headache. Migraine. Dentagra. Neuralgia. Mialgiya. Burns. Hyper thermal syndrome (Fever).


General characteristics. Structure:

international and chemical name: paracetamol; para-acetaminophenol;
main physical and chemical properties: tablets of color, white or white with a creamy shade, with a flat surface and a facet;
structure: one tablet contains paracetamol 0,2 g;
excipients: potato starch, polyvinylpirrolidone low-molecular, calcium стерат, aerosil.




Pharmacological properties:

Possesses analgetic, febrifugal and weak antiinflammatory action. The mechanism of action is connected with inhibition of synthesis of prostaglandins, preferential influence on the center of thermal control in a hypothalamus.


Pharmacokinetics. It is quickly and almost completely soaked up in the digestive channel. Bioavailability at intake - 100%. The maximum concentration in plasma is defined in 30-60 min. after intake. After a single dose it is found during 5 h. Well gets into fabrics. About 25% of the entered paracetamol contact proteins of plasma. To 80% of the accepted dose it is metabolized in a liver by a glyukuronidirovaniye and sulphation, only 3% are allocated with urine in not changed look.
The elimination half-life - 2-4 h at healthy and 8-12 h is at patients with liver diseases.


Indications to use:

Pain syndrome of weak and moderate intensity of various genesis (a headache, migraine, a dentagra, neuralgia, a mialgiya, альгодисменорея, pain at injuries, burns). Fever at infectious and inflammatory diseases.


Route of administration and doses:

Inside a single dose for adult 0,5 g, the maximum single dose - 1 g. Frequency rate of appointment to 4 times a day. Maximum daily dose of 4 g. Duration of a course of treatment is 5-7 days. Single doses for children: from 3 to 12 months - 0,024-0,12 g, 1-6 years - for 0,12-0,24, 6-12 years - 0,24 g. Frequency rate of appointment - 4 times a day, an interval between each reception - not less than 4 h. The maximum duration of treatment - 3 days.


Features of use:

With care appoint the patient with an abnormal liver function and kidneys, with a high-quality hyperbilirubinemia, at pregnancy and a lactation, and also to elderly patients.
At use of paracetamol control of a picture of peripheral blood and a functional condition of a liver is necessary.


Side effects:

Nausea, pains in epigastriums are possible; allergic reactions (skin rash, itch, small tortoiseshell, Quincke's edema). Seldom - anemia, thrombocytopenia, a methemoglobinemia. At prolonged use in high doses perhaps hepatotoxic action.
Contraindications. Hypersensitivity to drug; the expressed abnormal liver functions and/or kidneys; deficit of enzyme glyukozo-6-fosfatdegidrogenazy; blood diseases; children's age up to 3 months.


Interaction with other medicines:

Widely apply in various combinations with acetylsalicylic acid. codeine, caffeine, at the same time toxicity of paracetamol decreases, and its therapeutic effect amplifies. Barbiturates, anticonvulsants, rifampicin and alcohol strengthen a hepatotoxic action of paracetamol at co-administration.



Overdose:

Strengthening of the described side effects is possible.


Storage conditions:

To store in the dry, protected from light place.

Period of validity - 4 years.


Issue conditions:

According to the recipe


Packaging:

On 10 tablets in a blister strip packaging.



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