Максиколд® Rino

General characteristics. Structure:

Active agents: paracetamol of 325 mg, pheniramine maleate of 20 mg, Phenylephrinum hydrochloride of 10 mg, ascorbic acid of 50 mg;
excipients: citric acid monohydrate, malic acid, sucrose (refined sugar), titanium dioxide, sodium citrate a dihydrate, fragrance (lemon or orange or crimson), dye quinoline yellow, dye acid red (azoruby) (for crimson), calcium hydrophosphate a dihydrate (a trikaltion phosphate the three-main), ethyl cellulose.

Description

• powder for preparation of solution for intake (lemon):
  crystal powder lemon yellow color with a specific smell. Existence of crystals of white color and easily scattered lumps is allowed. Powder is dissolved in 250 ml of hot water with formation of opalescent solution of light yellow color with a characteristic smell of a lemon.
• powder for preparation of solution for intake (orange):
  crystal powder orange yellow color with a specific smell. Existence of crystals of white color and easily scattered lumps is allowed. Powder is dissolved in 250 ml of hot water with formation of opalescent solution of light yellow color with a characteristic smell of orange.
• powder for preparation of solution for intake (crimson):
  crystal powder crimson from color, light pink to dark pink with a reddish shade, with a specific smell. Existence of crystals of white color and easily scattered lumps is allowed. Powder is dissolved in 250 ml of hot water with formation of opalescent solution of pink color with a characteristic smell of raspberry.

Pharmacological properties:

The combined drug, possesses the febrifugal, vasoconstrictive, anesthetizing and antiallergic action. Paracetamol has febrifugal and analgeziruyushchy effect: reduces the pain syndrome which is observed at "catarrhal" diseases – a pharyngalgia, a headache, muscular and joint pain, reduces high temperature. Pheniramine has antiallergic effect: eliminates puffiness and a hyperemia of mucous membranes of a nasal cavity, a nasopharynx and adnexal bosoms of a nose, reduces cold and dacryagogue. Fenilefrin has vasoconstrictive effect: reduces puffiness of a mucous nasopharynx. Ascorbic acid (vitamin C) fills the increased need for vitamin C at  "catarrhal" diseases and flu, especially at initial stages of a disease; increases resistance of an organism to infectious diseases. Combined action of pheniramine and Phenylephrinum leads to reduction of a congestion of a nose and considerable simplification of nasal breath.

Indications to use:

Symptomatic treatment of the "catarrhal" diseases, SARS, flu which are followed by high temperature, a fever, a headache, cold, pain in bosoms of a nose and in a throat, a nose congestion, sneezing and muscle and joints pains.

Route of administration and doses:

To dissolve contents of one package in 1 glass of boiled hot water. To use hot. It is possible to add sugar to taste.

It is possible to accept a repeated dose every 4 hour (no more than 3 doses within 24 hours).

Максиколд® Rino from flu and cold can be applied at any time, but the best effect brings administration of drug before going to bed, for the night. If relief of symptoms within 3 days after the beginning of administration of drug is not observed, it is necessary to see a doctor.

Features of use:

• In order to avoid toxic damage of a liver paracetamol should not be combined with reception of alcoholic beverages, and also to accept to the persons inclined to chronic consumption of alcohol.
• The risk of development of injuries of a liver increases at patients with an alcoholic hepatosis. In case of administration of drug by the patients suffering from a diabetes mellitus or being on a diet with the lowered content of sugar it is necessary to consider that one bag contains 13 g of sugar that corresponds to 1,0 XE.
• During treatment it is not recommended to drive the car or other mechanisms demanding concentration of attention and high speed of psychomotor reactions.
• It is not necessary to use drug from the damaged bags.
  

Side effects:

Allergic reactions, drowsiness, nausea, epigastric pain, dryness in a mouth, accommodation paresis, a hyperexcitability, dizziness, increase in arterial pressure, backfilling disturbance, an ischuria are possible, it is rare: anemia.

Interaction with other medicines:

• It is recommended to refrain from administration of drug at reception of monoamine oxidase inhibitors. The risk of a hepatotoxic action of paracetamol increases at co-administration of barbiturates, dipheninum, carbamazepine, rifampicin, a zidovudine and other inductors of microsomal enzymes of a liver.
• Antidepressants, protivoparkinsonichesky and antipsychotic drugs, fenotiazinovy derivatives increase risk of development of an ischuria, dryness in a mouth, locks.
• Reduces hypotensive action of a guanetidin who in turn increases alpha адреностимулирующую activity of Phenylephrinum.

Contraindications:

Hypersensitivity to separate components of drug, the expressed liver/renal failure, pregnancy, the breastfeeding period, children's age (up to 12 years).

With care to appoint at: arterial hypertension, diabetes mellitus, closed-angle glaucoma, diseases of a liver or kidneys, prostate hyperplasia, deficit glyukozo-6-fosfatdegidrogenazy.

Overdose:

Symptoms: nausea, vomiting, pains in epigastric area; hepatotoxic and nephrotoxic action, in hard cases develops a liver failure, encephalopathy and coma.
Treatment: it is necessary to make a gastric lavage, to accept absorbent carbon and to see a doctor.

Storage conditions:

In the dry, protected from light place, at ^{a temperature not over 30 of 0C}.
To store in the place, unavailable to children. A period of validity - 2 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

Powder for preparation of solution for intake
(lemon, orange, crimson) 15 g.

On 15,0 g of drug in the thermowelded packages from the material combined. On 5 or 10 packages together with the application instruction place in a pack from a cardboard.