Piaron suspension

General characteristics. Structure:

Active ingredient: paracetamol; 5 ml of suspension contain paracetamol 120 mg.

Excipients: malic acid, anhydrous citric acid,
xanthane gum, maltit liquid, sorbite solution, sorbite (Е 420),
sodium methylparahydroxybenzoate (Е 219), sodium пропилпарагидроксибензоат (Е 217),
flavoring additive strawberry, кармоизин (Е 122), the water purified.

Pharmacological properties:

The analgetic and febrifugal effect of paracetamol is caused by synthesis oppression
prostaglandins and the prevailing influence on the center of thermal control in a hypothalamus.
Paracetamol is well soaked up in digestive tract. The peak of concentration in a blood plasma comes in 15–60 min. after reception. It is metabolized in a liver with formation of a glucuronide and sulfate of paracetamol. It is removed by the most part kidneys. An elimination half-life – from 1 to 4 hours.

Indications to use:

Pain during a teething, a dentagra, a pharyngalgia, heat at cold, flu and children's infections, such as chicken pox, whooping cough, measles, parotitis (mumps).
Drug is also recommended for treatment of a postvaccinal hyperthermia at babies by age 2–3 months.

Route of administration and doses:

Пиарон® apply to treatment of children age from 2 months to 12 years.
Drug is used orally. The paracetamol dose for all children is calculated depending on age and body weight.
The single dose of paracetamol makes 10–15 mg/kg of body weight, the maximum daily dose – 60 mg/kg of body weight. If necessary it is possible to repeat administration of drug each 4–6 hours. It is not necessary to accept more than 4 doses a day and more often than in 4 hours.
The maximum term of use of drug without recommendation of the doctor – 3 days.
Children age 2–3 months: the single dose of 2,5 ml of suspension is applied to a symptomatic treatment of reactions to vaccination. If necessary reception of a dose can be repeated, but not earlier, than in 4 hours. If the body temperature of the child does not decrease after a repeated dose, it is necessary to see a doctor. Further use of drug to children of the specified age perhaps only under supervision of the doctor.
Children age from 3 months to 12 years. Find a dose which corresponds to the child's weight in the table. If the weight of the child is unknown, find a dose which corresponds to age of the child in the table.
The table of dosing of suspension of paracetamol of 120 mg / 5 ml for children:

Typical body weight of the child	Age of the child	Dose (ml) of suspension
6–8 kg 8–10 kg 10–13 kg 13–15 kg 15–21 kg 21–29 kg 29–42 kg	3–6 months 6–12 months 1–2 years 2–3 years 3–6 years 6–9 years 9–12 years	4 ml 5 ml 7 ml 9 ml 10 ml 14 ml 20 ml

 

Features of use:

Use during pregnancy or feeding by a breast.
Drug is used only for treatment of children.

Ability to influence the speed of reactions at control of motor transport or work with other mechanisms.
Drug is used only for treatment of children.

Children.
It is not recommended to use drug to children age up to 2 months.

It is necessary to consult with the doctor concerning a possibility of use of drug for patients with renal failures and a liver. Sodium and пропилпарагидроксибензоат allergic reactions can cause methylparahydroxybenzoate. Children age 2–3 months which were born premature can use drug only according to the recommendation of the doctor.
It is not necessary to use drug to children along with other medicines which contain paracetamol.
If symptoms of a disease do not begin to disappear for 3 days of treatment by drug or, on the contrary, the state of health will worsen, then it is necessary to see a doctor.
Drug contains sorbite therefore can have insignificant laxative effect.
It is not necessary to exceed the specified doses.

Side effects:

Side reactions of paracetamol meet very seldom (<1/10000):
- from system of blood: anemia, sulfhemoglobinemia and methemoglobinemia (cyanosis, short wind, heartaches), hemolitic anemia;
- from immune system: an anaphylaxis, skin reactions of hypersensitivity, including an itch, an enanthesis and mucous membranes (usually erythematic, a small tortoiseshell), a Quincke's disease, a multiformny erythema (including Stephens-Johnson's syndrome), a toxic epidermal necrolysis (Lyell's disease);
- from respiratory system: a bronchospasm at the patients sensitive to aspirin and other non-steroidal anti-inflammatory drugs;
- from a digestive tract: nausea, pain in epigastriums, an abnormal liver function, increase in activity of liver enzymes, as a rule, without development of jaundice, гепатонекроз (dozozavisimy effect);
- from endocrine system: a hypoglycemia up to a hypoglycemic coma;
- others: aseptic pyuria.

Interaction with other medicines:

Speed of absorption of paracetamol can increase at simultaneous use of Metoclopramidum and domperidon and to decrease at use of a holestiramin. The anticoagulating effect of warfarin and other coumarins can amplify at simultaneous long use of paracetamol with increase in risk of bleeding. Periodic reception has no considerable effect. Barbiturates lower febrifugal effect of paracetamol.
Anti-convulsive drugs (including Phenytoinum, barbiturates, carbamazepine) which stimulate activity of microsomal enzymes of a liver, can strengthen toxic influence of paracetamol on a liver owing to increase in extent of transformation of drug to hepatotoxic metabolites. At simultaneous use of paracetamol with hepatotoxic means toxic influence of drug on a liver increases. Simultaneous use of high doses of paracetamol with an isoniazid increases risk of development of a hepatotoxic syndrome. Paracetamol lowers efficiency of diuretics.
Not to apply along with ethanol.

Contraindications:

Hypersensitivity to any of drug components. Heavy renal failures or/and a liver, an inborn hyperbilirubinemia, deficit glyukozo-6-fosfatdegidrogenazy, alcoholism, blood diseases, the expressed anemia, a leukopenia. Patients with rare hereditary intolerance of fructose. Children age up to 2 months.

Overdose:

At long use of drug in high doses development of aplastic anemia, a pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia is possible. At reception of high doses dizziness, psychomotor excitement, orientation disturbance, disturbance from an urinary system can be observed – nephrotoxicity (renal colic, intersticial nephrite, a papillary necrosis).
The overdose is, as a rule, caused by paracetamol and is shown by pallor of skin, anorexia, nausea, vomiting, abdominal pain, gepatonekrozy, increase in activity of hepatic transaminases and increase in a prothrombin ratio. In case of overdose the raised potovydeleniye, psychomotor excitement or oppression of the central nervous system, drowsiness, consciousness disturbance, disturbance of a cordial rhythm, tachycardia, premature ventricular contraction, a tremor, a hyperreflexia, spasms can be observed. Damage of a liver can be shown in 12–48 hours after overdose. Disturbance of metabolism of glucose and a metabolic acidosis can be noted. At a serious poisoning the liver failure can progress and lead to development of toxic encephalopathy with consciousness disturbance, in some cases – with a lethal outcome. The acute renal failure with an acute necrosis of tubules can develop even in the absence of severe damage of kidneys. Also cardiac arrhythmia was noted. Damage of a liver is possible at adults who accepted more than 10 g of drug, and at children who accepted more than 150 mg/kg of body weight.

At overdose of paracetamol quick medical aid is necessary even if symptoms of overdose are not revealed. It is necessary to wash out a stomach with further purpose of absorbent carbon, symptomatic therapy. Use of N-Acetylcysteinum intravenously or methionine orally effectively for 48 hours after overdose. It is necessary to take also all-supporting measures. If necessary apply alpha adrenoblockers.

Storage conditions:

To store at a temperature not above 25 °C, in protected from light and the place, unavailable to children. After the first opening of a bottle to store drug no more than 4 weeks.

Issue conditions:

Without recipe

Packaging:

On 100 ml in bottles. Each bottle in a cardboard box together with a measured glass.