Bravinton
Producer: CJSC Bryntsalov-A Russia
Code of automatic telephone exchange: N06BX18
Release form: Firm dosage forms. Tablets.
General characteristics. Structure:
Active ingredient: 0,005 g of a Vinpocetine in 1 tablet.
Excipients, aerosil, magnesium stearate, potato starch, talc, lactose.
Pharmacological properties:
Pharmacodynamics. Drug Bravinton selectively improves a blood stream of a brain and portability of cerebral ischemia. The mechanism is caused by direct spasmolytic myotropic action on brain vessels. Strengthens a regional blood stream in an ishemizovanny zone of a brain, causes insignificant lowering of arterial pressure.
The Vinpocetine improves microcirculation in brain tissues, slows down aggregation of thrombocytes, reduces viscosity of blood. Increases resistance of cells of a brain to a hypoxia, strengthens aerobic process of utilization of glucose. Stimulates also anaerobic metabolism of glucose by braking of phosphodiesterase and stimulation of adenylatecyclase that leads to accumulation in cells of a brain of cycling AMF. Raises contents of catecholamines in a brain.
Pharmacokinetics. At internal reception it is quickly and completely absorbed in digestive tract. Bioavailability - 50 - 70%. The maximum concentration in plasma is reached in 1 hour. Therapeutic concentration in a blood plasma makes 10 - 20 ng/ml. An elimination half-life - 4,8 hour.
Indications to use:
Mental and neurologic symptoms of disturbances of cerebral circulation of a different origin (after a stroke, a craniocereberal injury, at an ateroskleroza of vessels of a brain) such as memory disturbance, dizziness, headache, disturbances of the movement, etc.
In ophthalmologic practice: at vascular diseases of mesh and vascular covers of an eye, at the degenerative changes of a macula lutea caused by atherosclerosis or a vasomotor spasm; at secondary glaucoma.
In otolaryngology: at senile relative deafness, Menyer's disease, at decrease in hearing vascular or toxic (including medicamentous) genesis, a sonitus, dizziness of a labyrinth origin.
Route of administration and doses:
Accept inside 5 - 10 mg 3 times a day.
Maintenance dose - 5 mg 3 times for days. Apply it is long. Improvement of a state is observed ordinary in 1-2 weeks; a course of treatment - not less than 2 months.
Features of use:
With care appoint Bravinton sick with severe forms of cardiac arrhythmias, the expressed coronary heart disease.
It is necessary to be careful during the work with mechanisms.
Side effects:
Perhaps insignificant lowering of arterial pressure, tachycardia, seldom premature ventricular contraction.
Interaction with other medicines:
There are no data about any clinically powerful medicinal interactions of Bravinton.
Contraindications:
Pregnancy, lactation, hypersensitivity to drug.
Overdose:
Till today cases of overdose by Bravinton were not registered. In case of developing of intoxication the symptomatic treatment is recommended.
Storage conditions:
To store in dry, protected from light and the place, unavailable to children, at the room temperature. A period of storage - 2 years. Not to apply after the term specified on packaging.
Issue conditions:
According to the recipe
Packaging:
In a blister strip packaging of 10 pieces, in a cardboard pack 2 packagings or in plastic bottles on 50 pieces, in a cardboard pack 1 bottle.