Antistrumin-Darnitsa, the tab. on 0,001 g No. 50

General characteristics. Structure:

Active ingredient: potassium iodide;

1 tablet contains iodide potassium in terms of 100% dry matter of 1 mg;

excipients: sugar crystal, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Active ingredient of tablets Antistrumin-Darnitsa – potassium iodide – fills up deficit of ions of iodine in an organism, takes part in synthesis of hormones of a thyroid gland. As feedback inhibits synthesis of thyritropic hormone owing to what stops growth of a craw, normalizes products of hormones of a thyroid gland broken by a lack of iodine.

Pharmacokinetics. It is quickly soaked up in digestive tract. From blood comes to a thyroid gland, a mucous membrane of a stomach, a kidney, sialadens. The insignificant quantity is deposited in fatty tissue. In saliva, a gastric juice and breast milk concentration of iodine is 30 times higher, than its concentration in a blood plasma. About 80% of the accepted iodine are removed from an organism with urine through kidneys. With a fecal masses 10-15% are removed. 

Pharmaceutical characteristics.

The main physical and chemical svoystva:tabletka of white or almost white color, with a yellowish shade, a ploskotsilindrichesky form with a facet.

Indications to use:

Prevention and treatments of iodscarce states. Prevention of a local craw at an iodine deficiency in food stuffs and water. Prevention of a recurrence of a craw after a resection of a thyroid gland. Treatment of a diffusion euthyroid local craw.

Route of administration and doses:

Antistrumin-Darnitsa the adult to accept with the preventive purpose inside after food on 1 tablet once in 7 days with a large amount of liquid. At treatment of diffusion forms of a craw the daily dose makes 1 tablet (1 mg of potassium of iodide), and drug is accepted by 2-3 times a week. To children 12 years for the purpose of prevention are more senior appoint 1 tablet (1 mg) a week, at the same time prevention can continue several years. For prevention of irritation of a mucous membrane of a digestive tract drug is washed down with milk, kissel or sweet tea.

Usually for treatment of a craw at children 12 years are more senior and adults from 6 to 12 months and more are required.

Duration of treatment is determined by the doctor.

Features of use:

Antistrumin-Darnitsa it is not necessary to apply at a gipoterioza unless гипотериоз it is caused by an iodine deficiency.

Purpose of iodine it is necessary to avoid at therapy by a radioiodine, at existence or suspicion of cancer of a thyroid gland.

At patients with a renal failure the hyperpotassemia can develop.

At use of drug control of the doctor is necessary for treatment of children.

As the auxiliary component enters into composition of this medicine sugar crystal, it should be considered a sick diabetes mellitus.

Ability to influence speed of response at control of motor transport or work with other mechanisms.

There are no data.

Side effects:

At drug use Antistrumin-Darnitsa according to indications and in the recommended doses development of side reactions, as a rule, is improbable. Sometimes allergic reactions meet: very seldom – hypersensitivity reactions in combination with "iodic" rhinitis; "iodic" dermatitis, Quincke's edema; very seldom – "iodic" fever, "iodic" eels, an eosinophilia.

Interaction with other medicines:

It is necessary to avoid purpose of drugs of iodine as its excess reduces the corresponding reaction of a thyroid gland to the carried-out treatment of a hyperthyroidism thyreostatic drugs.

Substances which penetration into a thyroid gland happens on the same mechanism of "capture" as well as iodine penetration (perchlorate) – competitively slow down iodine absorption by a thyroid gland.

Substances which penetration into a thyroid gland is impossible without participation of specific carriers (thiocyanate) – competitively slow down iodine absorption by a thyroid gland.

Thyrotropinum – stimulates iodine absorption with a thyroid gland.

Lithium drugs – at simultaneous use from tireostatika the risk of development of a craw and a gipoterioz increases.

Kaliysberegayushchy diuretics – at simultaneous use development of a hyperpotassemia is possible.

Quinidine – at simultaneous use occurs strengthening of effect of quinidine on heart in connection with increase in potassium concentration in a blood plasma.

Vegetable alkaloids and salts of heavy metals – simultaneous use can lead to formation of an insoluble deposit and complicate iodine absorption.

Interferes with penetration of unstable isotopes of iodine into tissue of a thyroid gland.

Contraindications:

Hypersensitivity to iodine drugs, hyperfunction of a thyroid gland, a hyperthyroidism manifest, a hyperthyroidism hidden (at use of doses more than 150 mkg a day), toxic adenoma, toxic tumors of a thyroid gland, a nodal or diffusion toxic craw, nephrite, a nephrosis, hemorrhagic diathesis, a small tortoiseshell, dermatitis of Dyuringa, autonomous adenomas, a pulmonary tuberculosis, pregnancy, the feeding period a breast.

Use during pregnancy or feeding by a breast.

Drug in this dosage is not used during pregnancy and during feeding by a breast.

Children.

Drug is used to children aged 12 years are more senior.

Overdose:

At acute intoxication iodine observes reflex vomiting, abdominal pains, diarrhea (sometimes with blood), coloring of mucous membranes in brown color. There can come dehydration and shock. The gullet stenosis is in rare instances noted. The chronic overdose leads to a phenomenon which is called an iodism: metal smack in a mouth, hypostasis and an inflammation of mucous membranes (rhinitis, conjunctivitis, a gastroenteritis, bronchitis); acne rash; dermatitis; hypostasis and pains of sialadens; hemorrhages, fervescence; irritability.

At long use of high doses of drug (more than 300 mkg a day) development iodine – the induced hyperthyroidism is possible (especially at patients of advanced age in the presence of a nodal craw or toxic adenoma).

At therapy by high doses of iodine (more than 1 mg/days) in some cases can develop a craw and гипотериоз.

Treatment. First aid consists in a gastric lavage, reception of absorbent carbon. At use of a hemodialysis it is possible to reduce iodine level in a blood plasma.

Storage conditions:

Period of validity. 4 years. To store in the place, unavailable to children, in original packaging at a temperature not over 25 ºС.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in a blister strip packaging, on 5 or 10 blister strip packagings in a pack.