Glyurifor

General characteristics. Structure:

Active ingredient: 100 mg of rifampicin, 10 mg of ascorbic acid.

Glyurifor — a children's dosage form of rifampicin (an antibiotic of a broad spectrum of activity).

Pharmacological properties:

Pharmacodynamics. Rifampicin — an antibiotic of a broad spectrum of activity from group of Rifamycinums (ansamitsin). Has bactericidal effect. Has antibacterial, antitubercular, antileprotic effect. Breaks synthesis of RNA in a bacterial cell. It is highly active concerning mycobacteria of tuberculosis, gram-positive (staphylococcus, streptococci, sticks of a malignant anthrax, a clostridium) and some gram-negative bacteria. Works on causative agents of a brucellosis, legionellosis, sapropyra, leprosy, trachoma.

The ascorbic acid which is a part of drug is one of the most powerful natural antioxidants. Improves bile secretion, increases reduced vneshnesekretorny function of a pancreas, increases function of a thyroid gland. Regulates immunological reactions (activates synthesis of antibodies, C3 component of a complement, interferon), promotes phagocytosis, increases body resistance to various infections. Has antiinflammatory effect.

When using in the form of monotherapy to rifampicin stability quickly develops. Rifampicin is the powerful inductor of P450 cytochrome.

Pharmacokinetics. Rifampicin: it is quickly and fully soaked up in digestive tract. Bioavailability reaches 90 — 95%. Food reduces bioavailability of rifampicin. The maximum concentration of rifampicin in a blood plasma is reached in 2 — 2,5 hours after intake. Rifampicin is found in therapeutic concentration in pleural exudate, a phlegm, contents of cavities, a bone tissue; the greatest concentration is created in a liver and kidneys. Linkng with proteins of a blood plasma makes 80 — 90%. Rifampicin gets through a blood-brain barrier, a placenta, it is found in breast milk. It Biotransformirutsya in a liver. An elimination half-life — 2 — 5 hours. At the therapeutic level concentration of drug is maintained within 8 — 12 hours after reception, concerning highly sensitive activators — during 24 h. It is brought out of an organism with bile, a stake and urine.

Ascorbic acid: absorption of ascorbic acid happens in a small bowel. Level of absorption reaches 50-70%. Absorption decreases at the use of fresh fruit and vegetable juice, alkaline drink. Easily gets into leukocytes, thrombocytes, and then into all fabrics. It is metabolized, it is preferential in a liver. Not changed acid and metabolites are emitted with urine, and also with a stake and then.

Indications to use:

Glyurifor apply strictly on doctor's orders at treatment of children and teenagers, suffering from tuberculosis lungs and other localizations, and also at the nonspecific infections caused by microorganisms, sensitive to its action (pneumonia, bronchitis, lung abscess); quinsy, purulent otitis; infections to urine - and biliary tract (pyelonephritis, a pyelocystitis, a cholangitis, cholecystitis, etc.); infections of skin and soft tissues; at acute and an exacerbation of chronic osteomyelitis; at a meningococcal carriage.

Route of administration and doses:

Glyurifor in the form of suspension apply inside in 1 hour prior to meal or in 2 hours after meal.

Before reception package contents (0,1 g) are poured out in tea or a dessertspoon, mixed with boiled water, without breaking integrity of granules, and wash down with water.

At treatment of tuberculosis in order to avoid bystry formation of stability a glyurifor in the form of suspension apply as a part of a combination therapy (an isoniazid + streptomycin + a glyurifor). Glyurifor appoint in a daily dose 10 mg/kg (but no more than 0,6 g a day) in one step daily, at bad portability the daily dose can be divided into 2 receptions. Duration of treatment makes 2 months, if necessary lengthening of a course of treatment up to 4 months is possible.

At treatment of infections of not tubercular etiology to children the glyurifor in the form of suspension is appointed at the rate of 10 mg/kg a day, at the heavy course of infections the daily dose can be increased to 20 mg/kg (it is divided into 2 receptions). Duration of treatment is established individually depending on efficiency and portability and can make 7 — 10 days.

Newborn and premature children can appoint a glyurifor only according to vital indications in the absence of effect of other drugs.

At a meningococcal carriage drug is appointed in the daily dose 20 mg/kg distributed on 2 receptions within 2 days.

Features of use:

Urine, the lacrimal liquid, phlegm gain orange-red color from the patients accepting a glyurifor. At reception of a glyurifor coloring of contact lenses is possible.

 With care apply at liver diseases. Treatment by drug should be begun after the research of function of a liver (determination of level of bilirubin and aminotransferases in blood, a thymol turbidity test), and in the course of treatment to carry out it monthly. At the accruing phenomena of an abnormal liver function use of drug should be stopped. At prolonged use of drug it is necessary to control a blood pattern in connection with a possibility of development of a leukopenia.

With care apply at a pulmonary heart of the II-III degree, at the exhausted patients, at a porphyria.

Treatment by rifampicin has to be carried out under careful medical observation. At development of thrombocytopenia, a purpura, hemolitic anemia, renal failure and other serious undesirable reactions administration of drug is stopped.

In case of preventive use for bacilli carriers of a meningokokk strict control of the state of health of patients is necessary timely to reveal disease symptoms in case of resistance to rifampicin.

Side effects:

At reception of a glyurifor deterioration in appetite, nausea, vomiting, diarrhea can be observed. These phenomena proceed not hard and usually pass independently in 2 — 3 days without drug withdrawal. Glyurifor can have a hepatotoxic action (increase in concentration of aminotransferases and bilirubin in blood serum, cholestatic jaundice, hepatitis). Moderate abnormal liver functions usually have passing character and can be reduced without drug withdrawal at purpose of Allocholum, methionine, a pyridoxine, B12 vitamin.

At the accruing phenomena of an abnormal liver function use of a glyurifor should be stopped. At prolonged treatment glyurifory the leukopenia, thrombocytopenia, anemia, allergic reactions are in rare instances possible (in the form of skin rashes, an eosinophilia, etc.). At emergence of allergic reactions drug is cancelled and carry out the desensibilizing therapy (antihistamines, calcium drugs, etc.).

In some cases at administration of drug the headache, dizziness can be noted, it is rare - a canalicular necrosis, vision disorders, disturbances of a menstrual cycle, the grippopodobny syndrome (is more often at intermittent operations of reception) which is shown fever, a fever, an arthralgia, a mialgiya, an eosinophilia.

The risk of undesirable reactions increases at prolonged use, and also at a combination to an isoniazid.

Interaction with other medicines:

Rifampicin is one of the most powerful inductors of P450 cytochrome therefore it strengthens metabolism in a liver: cardiac glycosides, theophylline, hormones, lipophilic beta adrenoblockers, cyclosporine, indirect anticoagulants, peroral hypoglycemic means therefore their concentration in blood decrease and the effect is weakened.

Aluminum-bearing antacids reduce, and co-trimoxazole increases concentration of rifampicin in blood serum. Antagonism at a combination to Oxacillinum takes place.

Contraindications:

Use of a glyurifor is contraindicated to patients at hypersensitivity to drug, jaundice (including mechanical), the diseases of a liver and kidneys which are followed by the expressed disturbance of their functions, pregnancies and lactations.

Overdose:

Symptoms: nausea, vomiting, diarrhea, drowsiness, increase in a liver, jaundice, increase in level of bilirubin, hepatic transaminases in a blood plasma; brown-red or orange coloring of skin, urine, saliva, sweat, tears and excrements is proportional to the accepted drug dose.

Treatment: termination of administration of drug. Symptomatic therapy (there is no specific antidote). Gastric lavage. Maintenance of the vital functions.

Issue conditions:

According to the recipe

Packaging:

Granules for preparation of suspension for intake of 100 mg in packages 1g in packaging No. 30.