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9 months. Folic acid

Препарат 9 месяцев. Фолиевая кислота. ОАО "Валента Фармацевтика" Россия

Producer: JSC Valenta Pharmatsevtika Russia

Code of automatic telephone exchange: B03BB01

Release form: Firm dosage forms. Tablets.

Indications to use: B9 Hypovitaminosis.

General characteristics. Structure:

Active ingredient: folic acid of 400 mkg

Excipients: lactoses monohydrate (tablettoza 80), silicon dioxide colloid, коповидон (коллидон VA-64), magnesium stearate.

Structure of a cover: опадрай II (series 85) (polyvinyl alcohol, a macrogoal, talc, titanium dioxide (E171), ferrous oxide yellow (E172), an aluminum varnish on the basis of quinolinic yellow (E104).

Pharmacological properties:

Group B vitamin (vitamin of AF, B9 vitamin) can be synthesized by intestinal microflora. In an organism folic acid is recovered to the tetrahydrofolic acid which is the coenzyme participating in various metabolic processes. It is necessary for normal maturing of megaloblasts and formation of normoblasts. Stimulates an erythrogenesis, participates in synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in exchange of sincaline, a histidine.

Pharmacokinetics. Absorption and distribution
Folic acid is well and fully soaked up in a GIT, is preferential in upper parts of a duodenum. Cmax in a blood plasma is reached in 30-60 min.
Almost completely contacts proteins of plasma. Gets through GEB and a placental barrier and it is allocated with breast milk.

Metabolism and removal. Is exposed to activation in a liver under the influence of digidrofolatreduktaza enzyme, turning into tetrahydrofolic acid.
It is removed by kidneys preferential in the form of metabolites; if the accepted dose considerably exceeds the daily need for folic acid, then is removed in not changed look.

It is removed by means of a hemodialysis.

Indications to use:

— deficit of folic acid;
— prevention of development of defects of a neurotubule in a fruit in the I trimester of pregnancy.

Route of administration and doses:

Apply inside after food.
- At deficit of folic acid - 400 mkg (1 tablets) /
- For prevention of development of defects of a neurotubule in a fruit in the I trimester of pregnancy - 400-800 mkg (1-2 tablets).

Features of use:

For prevention of a hypovitaminosis the most preferably balanced food. The products rich with folic acid - green vegetables (salad, spinach, tomatoes, carrots), a fresh liver, bean, beet, eggs, cheese, nuts, cereals.
Folic acid is not applied to treatment of B12-scarce (pernicious), normotsitarny and aplastic anemia, and also anemia, refractory to therapy. At pernicious (B12-scarce) anemia folic acid, improving hematologic indicators, masks neurologic complications. Pernicious anemia, purpose of folic acid in the doses exceeding 100 mkg / is not excluded yet, it is not recommended (an exception - pregnancy and the period of a lactation).
It must be kept in mind that the patients who are on a hemodialysis need the increased amounts of folic acid.
During treatment antacids should be applied later 2 h after reception of folic acid, Colestyraminum - for 4-6 h to or later 1 h after reception of folic acid.
It must be kept in mind that antibiotics can distort (to yield obviously underestimated indicators) results of microbiological assessment of concentration of folic acid of plasma and erythrocytes.
At use of high doses of folic acid, and also therapy during the long period decrease in concentration of B12 vitamin is possible.

Side effects:

Allergic reactions: skin rash, itch, bronchospasm, erythema, hyperthermia.
From the alimentary system: nausea, abdominal distention, bitterness in a mouth, anorexia.
Others: at prolonged use development of a hypovitaminosis of B12 is possible.

Interaction with other medicines:

At simultaneous use reduces effect of Phenytoinum (increase in its dose is required).
Analgetics (long therapy), anticonvulsant drugs (including Phenytoinum and carbamazepine), are oestrogenic, oral contraceptives increase the need for folic acid.
Antacids, Colestyraminum, sulfonamina (including Sulfasalazinum) reduce absorption of folic acid.
The methotrexate, Pyrimethaminum, Triamterenum, Trimethoprimum inhibit a digidrofolatreduktaza and reduce effect of folic acid (instead of it the patients using these drugs should appoint calcium фолинат).
At simultaneous use with chloramphenicol, polymyxins, tetracyclines absorption of folic acid decreases.


— pernicious anemia;
— malignant new growths;
— deficit of cobalamine;
— children's age;
— hypersensitivity to the components which are a part of drug.

Use of drug of 9 MONTHS FOLIC ACID at pregnancy and feeding by a breast
Folic acid is necessary during preparation for pregnancy (in 1-3 months until the planned pregnancy) and in the first several weeks after conception (the I trimester).

Use for children
It is contraindicated at children's age.


Can arise at long reception (more than 1-2 months) of folic acid in doses over 1000 mkg as a result of combined use with vitamino-mineral complexes.

Storage conditions:

Drug should be stored in dry, protected from light, the place, unavailable to children, at a temperature not above 25 °C.

Issue conditions:

Without recipe


Tablets, film obol., 400 mkg: 30 pieces.

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