Dimedrol

General characteristics. Structure:

1 tablet contains a difengidramin of a hydrochloride (​​ Dimedrol) 0,05 g

Excipients: sugar milk, potato starch, stearic acid, aerosil

The main physics - chemical properties: tablets of white color, with a plain and smooth surface.

Pharmacological properties:

Pharmacodynamics. Dimedrol belongs to effective antihistamines which block histamine H1 - receptors. Removes a spasm of smooth muscles (direct action), reduces permeability of capillaries, warns and weakens allergic reactions, has mestnoanesteziruyushchy, antiemetic, sedative effects, moderately blocks holinoretseptor vegetative ганглиев, renders somnolent effect. The main effect of drug is caused central cholinolytic by activity and, perhaps, influence on histamine H3 - brain receptors.

Pharmacokinetics. At intake it is quickly and well soaked up in zheludochno - an intestinal path. Communication - contacts proteins of plasma for 98 - 99%. The maximum concentration in a blood plasma is reached in 1-4 h after intake. The most part is metabolized in a liver, smaller - is removed in not changed view with urine for 24 h. The elimination half-life makes 1-4 hours. Passes through a blood-brain barrier. It is excreted with milk and can cause sedation in newborns. The maximum activity develops in 1 h, action duration - from 4 to 6 hours.

Indications to use:

Acute anaphylaxis, small tortoiseshell, hay fever, serum disease, hemorrhagic vasculitis (capillary toxicosis), hemorrhagic diathesis, vasculomotor cold, multiformny exudative erythema, Quincke's disease of Quincke, contact dermatitis of various genesis, pruritic dermatosis, itch, allergic game - pruritic and other allergic diseases of eyes, allergic reactions, эт - connected with drug intake. Besides, Dimedrol is applied at a radial illness, bronchial asthma (in combination with other means), sometimes - at a peptic ulcer of a stomach, a 12-perstny gut and hyperacid gastritis, choreas, sea and air diseases, Menyer's disease, vomiting of pregnant women, postoperative vomiting, concussion, burns, freezing injuries, sleeplessness, neurosises, a neurasthenia. In anesthesiology Dimedrol is a part of lytic mix. As sedative and a hypnagogue Dimedrol is applied independently or in a complex with other hypnotic drugs.
Use for easing of side effects at a transfusion of blood and blood substitutes, use of fermental drugs.

Route of administration and doses:

Children: Up to 6 years it is recommended to children of a tablet of other dosing. To children 6 years are more senior appoint ½ tablets of 1 times a day.

Adults: The adult appoint 0,05 g of 1 - 3 time a day. A course of treatment - 10 - 15 days. The maximum single dose of per os for adults - 0,1 g, daily - 0,25 g.

Features of use:

As Dimedrol renders sedative and somnolent effects, drug is not appointed before and in operating time to drivers of transport, other persons whose professional activity demands proper mental and motor reactions.

Side effects:

Dryness in a mouth, nausea, vomiting, dysfunction of system of digestion, a lack of coordination, feeling of fatigue, drowsiness, dizziness, a headache. By-effects pass after reduction of a dose or drug withdrawal.

Interaction with other medicines:

Dimedrol exponentiates effect of the hypnotic drugs, neuroleptics, narcotic analgetics and other medicines oppressing the central nervous system, strengthens effect of holinoblokator and reduces motility of a digestive tract, significantly reducing absorption of medicines, at the same time appoint to the patient (for example, indirect anticoagulants, paracetamol). Interacting with alcohol, increases its toxicity.

Contraindications:

Hypersensitivity to drug.

Overdose:

Symptoms: dryness in a mouth, the complicated breath, a resistant mydriasis, face reddening, oppression or excitement (is more often at children) TsNS, confusion of consciousness, children have a development of spasms and a lethal outcome.
Treatment: induction of vomiting, gastric lavage, purpose of absorbent carbon; a systematic and maintenance therapy against the background of careful control of breath and the ABP level.

Storage conditions:

To store in the unavailable to children, protected from light place at a temperature from 15 °C to + 25 °C. A period of storage - 4 years.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in planimetric bezjyacheykovy packagings.