Pancreatinum

General characteristics. Structure:

Active ingredient: 25 PIECES of Pancreatinum.

Pharmacological properties:

Pharmacodynamics. Fermental means. Contains excretory pancreatic enzymes: lipase, alpha amylase, trypsin, chymotrypsin. Promotes the proteolysis to amino acids, fats – to glycerin and fatty acids and starch – to dextrins and monosugars. Normalizes digestion processes. Trypsin in the upper site of a small intestine inhibits stimulated secretion of a pancreas, causing analgesic effect of Pancreatinum. The maximum enzymatic activity of drug is noted in 30-45 minutes after oral administration.

Pharmacokinetics. Tablets are protected from action of a gastric juice by a cover therefore the enzymes which are a part of Pancreatinum are released in the alkaline environment of a small intestine where have pharmacological effect.

Indications to use:

Drug is used at disturbance of exocrine function of a pancreas (a mucoviscidosis; chronic pancreatitis, pancreatectomy, dyspepsias); at an akhiliya; anacid and gipoatsidny gastritises; at the digestive disturbances connected with chronic diseases in system of a liver and biliary tract; at reception of greasy, unusual food hard to digest; for decontamination of intestines before diagnostic testings (radiological, ultrasonography and others).

Route of administration and doses:

Drug is accepted in 3-6 times a day, just before food or during food, without chewing and washing down with a large amount of liquid (water, fruit juice). The dose is established individually, depending on age and severity of a digestive disturbance.

The adult it is usually appointed in a single dose of 50-100 PIECES (2-4 tablets); the daily dose makes 200-400 PIECES (8-16 tablets).

Average single dose for children of 6-7 years – 25 PIECES (1 tablet), 8-9 years – 25-50 PIECES (1-2 tablets), 10-14 years – 50 PIECES (2 tablets).

Duration of treatment can vary of several days (at disturbance of digestion owing to an error in a diet) up to several months and even years (in need of performing continuous replacement therapy).

Features of use:

Pregnancy and lactation: Use of drug during pregnancy and during feeding by a breast perhaps only if the expected advantage for mother exceeds potential risk for a fruit.

Drug does not render a negative impact on ability to drive the car and potentially dangerous mechanisms.

Side effects:

Allergic reactions, it is rare - diarrhea or a lock, nausea, discomfort in epigastric area. At dlitelyey use in high doses - a hyper uricosuria, a hyperuricemia, structures in ileocecal department and in the ascending colon.

Interaction with other medicines:

Forms insoluble complexes with folates owing to what their absorption significantly decreases. Reduces iron absorption (especially at prolonged use).

Simultaneous use of antiacid means, calciferous a carbonate and/or magnesium hydroxide, can lead to decrease in efficiency of Pancreatinum.

Contraindications:

Hypersensitivity to drug components, acute pancreatitis, an exacerbation of chronic pancreatitis.

Overdose:

Symptoms: a hyper uricosuria, a hyperuricemia, children have locks.

Treatment: drug withdrawal, symptomatic therapy.

Issue conditions:

According to the recipe

Packaging:

The tablets covered with a kishechnorastvorimy cover, 25 PIECES in a blister strip packaging No. 10х5.