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medicalmeds.eu Medicines Antiseptic agents and antimicrobic drugs Clotrimazolum

Clotrimazolum

Препарат Клотримазол. ООО «Фармлэнд» Республика Беларусь


Producer: LLC Pharmlend Republic of Belarus

Code of automatic telephone exchange: G01AF02

Release form: Firm dosage forms. Tablets.

Indications to use: Trichomoniasis. Vulvovaginitis. Candidiasis of a vagina (Milkwoman).


General characteristics. Structure:

Acting substance: 100 mg of Clotrimazolum.

Excipients: lactose monohydrate (Tablettoza-80), potato starch, Kopovidon (коллидон 64), кросповидон (коллидон CL), magnesium stearate, adipic acid.

Antifungal broad-spectrum agent.




Pharmacological properties:

Pharmacodynamics. Clotrimazolum is derivative an imidazole. Antifungal broad-spectrum agent. The effect of drug is connected with disturbance of synthesis of ergosterol, is a part of a cellular membrane of mushrooms that causes change of its structure and properties and leads to a lysis of a cell.

Dermatophytes, barmy mushrooms (the sorts Candida, Torulopsis glabrata, the sorts Rhodotorula), mold mushrooms, and also the Pityriasis versicolor activator (multi-colored depriving) and the erythrasma activator are sensitive to Clotrimazolum.

Besides, has antimicrobic effect concerning gram-positive (staphylococcus and streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), and also concerning Trichomonas vaginalis, Malasseria furfur, Corinebacterium minussimum.

Pharmacokinetics. At external use Clotrimazolum is practically not absorbed in a system blood stream through integuments, in small degree is absorbed from mucous membranes.


Indications to use:

The genital infections caused by barmy mushrooms of the sort Candida and/or Trichomonas vaginalis (a candidosis vulvovaginitis, trichomoniasis), the genital superinfections caused by the bacteria sensitive to Clotrimazolum.


Route of administration and doses:

For treatment of vaginal infections appoint on 1 tablet (100 mg) of 1 times a day (evening).

Vaginal tablets enter as it is possible more deeply in a vagina.

Duration of treatment makes 6 days.

If necessary the course of treatment can be repeated.


Features of use:

Prevention of spread of an urogenital infection requires simultaneous treatment of sexual partners. At trichomoniasis for more successful treatment together with Clotrimazolum it is necessary to appoint other medicines possessing systemic action.

Vaginal tablets are not recommended to be applied during periods.

Pregnancy and lactation. At clinical and pilot studies it was not established that use of Clotrimazolum during pregnancy and in the period of a lactation makes negative impact on health of the woman or a fruit (child). However the issue of expediency of purpose of Clotrimazolum has to be resolved individually after consultation of the doctor. In case of purpose of drug to the pregnant woman, it is necessary to warn her that at introduction of vaginal tablets it is not necessary to use the applicator.


Side effects:

Local reactions - reddening mucous, a burning sensation and prickings are in rare instances noted.


Interaction with other medicines:

At vaginal introduction Clotrimazolum reduces activity of Amphotericinum In and other half-yen antibiotics. At simultaneous use with nystatin activity of Clotrimazolum can decrease.


Contraindications:

Hypersensitivity to Clotrimazolum and other components of drug.


Overdose:

In case of an unforeseen route of administration of drug the following symptoms - anorexia, nausea, vomiting, a gastralgia, an abnormal liver function, seldom drowsiness, hallucinations, a pollakiuria, skin allergic reactions are (orally) possible. In a verse situations it is necessary to accept absorbent carbon and to see a doctor.


Storage conditions:

To store in the dry, protected from light place at a temperature not above +25 °C. Period of validity 2 years.


Issue conditions:

Without recipe


Packaging:

On 6 tablets in banks of medicines, polymeric for packaging. One bank together with a leaf insert in secondary packaging (pack).



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