Bromhexine

General characteristics. Structure:

Active ingredient: 4 mg or 8 mg of Bromhexine of a hydrochloride.

Excipients: lactose, sucrose, potato starch, calcium stearate, sodium carboxymethylstarch. 

Pharmacological properties:

Pharmacodynamics. Drug renders mucolytic (sekretolitichesky) and expectorant action. The mucolytic effect is connected with a depolymerization and fluidifying of mucoprotein and mukopolisakharidny fibers. Bromhexine has weak antibechic effect. Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath. The clinical effect is shown in 2-5 days from an initiation of treatment by drug.

Pharmacokinetics. At intake Bromhexine almost completely (99%) is soaked up within 30 minutes. About 80% of Bromhexine are exposed to intensive metabolism owing to "the first passing through a liver". In plasma Bromhexine contacts proteins, gets through hematoencephalic and placental barriers.

In a liver Bromhexine is exposed to demethylation and oxidation with formation of an active metabolite — Ambroxol. The elimination half-life makes 15 h owing to slow return diffusion of fabrics. It is removed by kidneys. At a chronic renal failure removal of metabolites of Bromhexine is broken. At repeated use Bromhexine can kumulirovat.

Indications to use:

The bronchopulmonary diseases which are followed by formation of a phlegm of the increased viscosity (bronchial asthma, a mucoviscidosis, a pulmonary tuberculosis, pneumonia, a tracheobronchitis, obstructive bronchitis, bronchiectasias, emphysema of lungs, a pneumoconiosis).

Route of administration and doses:

Inside, irrespective of meal. To adults and children 14 years — 8-16 mg 3-4 times a day are more senior.

To children aged from 3 up to 5 years — 4 mg 3 times a day, 6-14 years — 8 mg 3 times a day. A course of treatment — from 4 to 28 days.

Features of use:

In the course of treatment it is recommended to use enough liquid that supports sekretolitichesky action of Bromhexine.

At children treatment should be combined with postural drenazhy or the vibration massage of a thorax facilitating evacuation of a secret from bronchial tubes.

Side effects:

Seldom, at long administration of drug the dispepsichesky phenomena, dizziness, a headache, an aggravation of a peptic ulcer, allergic reactions (skin rash, rhinitis), increase in activity of "hepatic" transaminases in blood serum are possible. In these cases it is necessary to cancel drug.

Interaction with other medicines:

Bromhexine do not appoint along with the medicines suppressing the tussive center (including containing codeine) as it complicates evacuation of the liquefied phlegm.

Bromhexine promotes penetration of antibiotics (erythromycin, cefalexin, Oxytetracyclinum) into a bronchial secret.

Bromhexine is not compatible to alkaline solutions.

Contraindications:

Hypersensitivity to drug components, pregnancy (the I trimester), the lactation period, a peptic ulcer (in an aggravation stage), children's age up to 3 years.

With care. Gastric bleedings in the anamnesis, a renal and/or liver failure, diseases of bronchial tubes which are followed by excessive accumulation of a secret.

Overdose:

Symptoms: nausea, vomiting, diarrhea.

Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).

Storage conditions:

To store in the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children. Not to use after the date specified on packaging. A period of validity - 5 years.

Issue conditions:

Without recipe

Packaging:

Tablets on 4 mg or 8 mg. On 20 or 50 tablets in bank of orange glass; on 10 tablets in a blister strip packaging. Each can or 1, 2, 3, 4, 5 or 10 blister strip packagings together with the application instruction are placed in a pack from a cardboard.