Obolenskoye's Bromhexine

General characteristics. Structure:

Active ingredient: 0,004 g or 0,008 g of Bromhexine of a hydrochloride in 1 tablet.

Excipients: sugar milk (lactose), microcrystallic cellulose, magnesium stearate, sugar (sucrose), polyvinylpirrolidone (povidone), magnesium carbonate the main, aerosil (silicon dioxide colloid), talc, titanium dioxide, beeswax, sunflower oil, red food dye or quinolinic yellow.

Has expectorant, mucolytic effect at the expense of a depolymerization of protein and mukopolisakharidny fibers. Has weak antibechic effect, in high doses has emitichesky properties.

Pharmacological properties:

Pharmacodynamics. Drug renders mucolytic (sekretolitichesky) and expectorant action. The mucolytic effect is connected with a depomirelization and fluidifying of mucoprotein and mukopolisakharidny fibers. Bromhexine has weak antibechic effect.

Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath. The clinical effect is shown in 2-5 days from an initiation of treatment by drug.

Pharmacokinetics. At intake almost completely (99%) it is soaked up within 30 min. Bioavailability makes-80% (effect of "the first passing" through a liver). In plasma Bromhexine contacts proteins, gets through a blood-brain and placental barrier. In a liver Bromhexine is exposed to demethylation and oxidation.

The elimination half-life makes 15 h owing to slow return diffusion of fabrics. It is removed by kidneys. At a chronic renal failure it is broken by allocation of metabolites of Bromhexine. At repeated use Bromhexine can kumulirovat.

Indications to use:

The bronchopulmonary diseases which are followed by formation of a phlegm of the increased viscosity (bronchial asthma, a mucoviscidosis, tuberculosis, pneumonia, a tracheobronchitis, obstructive bronchitis, bronchiectasias, emphysema of lungs, a pneumoconiosis) before – and the postoperative period.

Route of administration and doses:

Bromhexine is accepted inside, irrespective of meal. The adult appoint 8-16 mg 3-4 times a day; from 6 to 14 years - 8 mg 3 times a day. Course of treatment from 4 to 28 days.

In the course of treatment it is recommended to use enough liquid that supports sekretologichesky action of Bromhexine.

At children treatment should be combined with postural drenazhy or the vibration massage of a thorax facilitating evacuation of a secret from bronchial tubes.

Side effects:

Seldom, at long administration of drug nausea, vomiting, the dispepsichesky phenomena, dizziness, a headache, an aggravation of a peptic ulcer, allergic reactions (skin rash, rhinitis, etc.) increase in activity of "hepatic" transaminases in blood serum is possible. In these cases it is necessary to cancel drug.

Interaction with other medicines:

It is possible to appoint Bromhexine along with other drugs used at treatment of bronchopulmonary diseases.

Bromhexine is not appointed along with the medicines containing codeine as it complicates evacuation of the liquefied phlegm.

Bromhexine promotes penetration of antibiotics (erythromycin, cefalexin, Oxytetracyclinum) into pulmonary fabric.

Bromhexine is not compatible to alkaline solutions.

Contraindications:

- Hypersensitivity to drug components;

- Pregnancy (I trimester);

- Lactation period;

- A peptic ulcer (in an aggravation stage);

- Children's age up to 6 years

With care: Bromhexine should be accepted at the weakened patients, with gastric bleeding in the anamnesis, a renal and/or liver failure; and also the patients with a disease of bronchial tubes who are followed by excessive accumulation of a secret.

Overdose:

Symptoms: nausea, vomiting, diarrhea, dispepsichesky frustration.

Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).

Storage conditions:

In the dry, protected from light place unavailable to children. A period of validity - 3 years.

Issue conditions:

Without recipe

Packaging:

On 10 or 20 tablets in a blister strip packaging. On 1, 2, 3, 4, 5 or 10 blister strip packagings together with the application instruction in a pack from a cardboard.