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Bromhexine

Препарат Бромгексин. ООО "Озон" Россия


Producer: LLC Ozon Russia

Code of automatic telephone exchange: R05CB02

Release form: Firm dosage forms. Tablets.

Indications to use: Bronchial asthma. Mucoviscidosis. Tuberculosis. Pneumonia. Tracheobronchitis. Bronchitis. Bronchiectasias. Emphysema of lungs. Pneumoconiosis. Postoperative period.


General characteristics. Structure:

Active agent: Bromhexine a hydrochloride - 8,0 mg.
Excipients: lactoses monohydrate (sugar milk) - 101,5 mg; starch corn - 15,0 mg; povidone (polyvinylpirrolidone) - 4,5 mg; magnesium stearate - 1,0 mg.
Description: Round ploskotsilindrichesky tablets of white or almost white color with risky on the one hand and facets from two parties.




Pharmacological properties:

Pharmacodynamics.
Drug renders mucolytic (sekretolitichesky) and expectorant action. The mucolytic effect is connected with a depolymerization and fluidifying of mucoprotein and mukopolisakharidny fibers. Bromhexine has weak antibechic effect.
Pharmacokinetics.
At intake Bromhexine almost completely (99%) is soaked up within 30 minutes. Bioavailability makes 80% owing to effect of "the first passing" through a liver. In plasma Bromhexine contacts proteins, gets through hematoencephalic and placental barriers. In a liver Bromhexine is exposed to demethylation and oxidation. The elimination half-life makes 15 h owing to slow return diffusion of fabrics. It is excreted by kidneys. At a chronic renal failure removal of metabolites of Bromhexine is broken. At repeated use Bromhexine can kumulirovat.


Indications to use:

The bronchopulmonary diseases accompanying with formation of a phlegm of the increased viscosity (bronchial asthma, a mucoviscidosis, tuberculosis, pneumonia, a tracheobronchitis, obstructive bronchitis, bronchiectasias, emphysema of lungs, a pneumoconiosis), thorax injuries before - and the postoperative period.


Route of administration and doses:

Bromhexine is applied inside irrespective of meal. The adult appoint 1-2 tablets 3-4 times a day; to children from 3 to 5 years - 2 mg, from 6 to 14 years - 4 mg 3 times a day. A course of treatment - from 4 to 28 days. In the course of treatment it is recommended to use enough liquid that supports ekretolichesky action of Bromhexine



Side effects:

Seldom, at long administration of drug nausea, vomiting, the dispepsichesky phenomena, an aggravation of a peptic ulcer, allergic reactions (skin rash, rhinitis, etc.), increase in level of transaminases are possible
in blood serum. In these cases it is necessary to cancel drug.


Interaction with other medicines:

It is possible to appoint Bromhexine along with other drugs used at treatment of bronchopulmonary diseases.
Bromhexine is not appointed along with the medicines containing codeine as it complicates expectoration of the liquefied phlegm. Bromhexine promotes penetration of antibiotics (erythromycin, cefalexin, an oxytetrawedge) into pulmonary fabric. Bromhexine is not compatible to alkaline


Contraindications:

- hypersensitivity to drug components;
- pregnancy (1 trimester);
- lactation period;
- children's age up to 3 years.



Storage conditions:

In the dry, protected from light place, at a temperature not above 25 °C. To store in the place, unavailable to children. Period of validity 3 years. This medicine cannot be used after the date specified on packaging.


Issue conditions:

Without recipe


Packaging:

Tablets on 0,008 g
On 10, 20, 30, 40, 50 tablets in a blister strip packaging from a film of the polyvinyl chloride and printing aluminum foil varnished.
On 10, 20, 30, 40, 50 or 100 tablets in banks polymeric for medicines.
To one bank or 1, 2, 3, 4, 5 or 10 blister strip packagings together with the application instruction place in cardboard packaging (pack).



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