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medicalmeds.eu Medicines Expectorant mucolytic means. Bromhexine

Bromhexine

Препарат Бромгексин . ЗАО ПФК "Обновление" Россия


Producer: CJSC PFK Obnovleniye Rossiya

Code of automatic telephone exchange: R05CB02

Release form: Firm dosage forms. Tablets.

Indications to use: Tracheobronchitis. Bronchitis. Bronchiectasias. Bronchial asthma. Pulmonary tuberculosis. Pneumonia. Mucoviscidosis. Sanitation of a bronchial tree.


General characteristics. Structure:

Active ingredient: 0,008 g of Bromhexine.

Excipients: sucrose (sugar), potato starch, calcium stearate.




Pharmacological properties:

Pharmacodynamics. Mucolytic (sekretolitichesky) means, has expectorant and weak antibechic effect. Reduces viscosity of a phlegm (depolymerizes mucoprotein and mukopolisakharidny fibers, increases a serous component of a bronchial secret); activates a ciliary epithelium, increases volume and improves otkhozhdeny phlegms. Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath. The effect is shown in 2-5 days from an initiation of treatment.

Pharmacokinetics. At intake almost completely (99%) it is soaked up in digestive tract within 30 min. Bioavailability makes 80%. Gets through a placental barrier and a blood-brain barrier (GEB).

In a liver is exposed to dimethylation and oxidation, it is metabolized to pharmacological active Ambroxol. T1/2 – 15 h (owing to slow return diffusion from fabrics). It is removed by kidneys. At a chronic renal failure removal of metabolites is broken. At repeated use can kumulirovat.


Indications to use:

The diseases of respiratory tract which are followed by difficulty of an otkhozhdeniye of a viscous phlegm: a tracheobronchitis, bronchitis of a different etiology (including complicated by bronchiectasias), bronchial asthma, a pulmonary tuberculosis, pneumonia (acute and chronic), a mucoviscidosis.

Sanitation of a bronchial tree in the preoperative period and when carrying out medical and diagnostic intra bronchial manipulations, prevention of accumulation in bronchial tubes of a dense viscous phlegm after operation.


Route of administration and doses:

Inside to adults and children 14 years – 8-16 mg (1-2 tablets) 3-4 times a day are more senior. To children at the age of 6-14 years – 8 mg (1 tablet) Z times a day. If necessary the dose can be increased by the adult to 16 mg (2 tablets) 4 times a day.

Therapeutic action can be shown for 4-6 day of treatment. The patient with a renal failure appoint smaller doses or increase an interval between introductions.


Features of use:

At treatment it is necessary to accept enough liquid that increases expectorant effect of Bromhexine.

At children treatment should be combined with postural drenazhy or the vibration massage of a thorax facilitating removal of a secret from bronchial tubes.


Side effects:

Allergic reactions, nausea, vomiting, dyspepsia, aggravation of a peptic ulcer of a stomach and 12-perstny gut, dizziness, headache, increase in activity of "hepatic" transaminases (extremely seldom).


Interaction with other medicines:

Do not appoint along with the medicines suppressing the tussive center (including codeine) as it complicates an otkhozhdeniye of the liquefied phlegm (accumulation of a bronchial secret in respiratory tracts).

It is incompatible with alkaline solutions.

Bromhexine promotes penetration of antibiotics (amoxicillin, erythromycin, cefalexin, Oxytetracyclinum), sulfanamide medicines in a bronchial secret in the first 4-5 days of antimicrobic therapy.


Contraindications:

Hypersensitivity, round ulcer of a stomach, pregnancy (I trimester); lactation period; children's age (up to 6 years).

With care. Renal and/or liver failure; the diseases of bronchial tubes which are followed by excessive accumulation of a secret in the anamnesis – gastric bleeding.


Overdose:

Symptoms: nausea, vomiting, diarrhea, dispepsichesky frustration.

Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).


Storage conditions:

To store in the dry, protected from light place at a temperature not above 25 °C. To store in the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Tablets of 8 mg. On 10, 20, 30, 50 tablets in a blister strip packaging. On 50 tablets in a glass jar. Each can or 1, 2, 3, 5 blister strip packagings with the application instruction in a pack. On 2500 blister strip packagings on 10 tablets or 600 blister strip packagings on 50 tablets with the equal number of application instructions place in group packaging.



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