Bromhexine
Producer: JSC Himfarm Republic of Kazakhstan
Code of automatic telephone exchange: R05CB02
Release form: Liquid dosage forms. Syrup.
General characteristics. Structure:
Active agent - Bromhexine a hydrochloride of 0,080 g.
Excipients: menthol, peppermint oil, oil of a sage muscat, sugar, methylparapetrolxybenzoate, alcohol of ethyl 95%, the water purified.
Pharmacological properties:
Pharmacokinetics. At intake Bromhexine almost completely (99%) is soaked up in the digestive tract (DT) within 30 minutes, however is exposed to intensive metabolism at "the first passing" through a liver. Therefore its bioavailability low, on average 20%. The maximum concentration in plasma is defined by 1 h. Linkng with proteins of plasma high also makes 80-90%. Bromhexine gets through hematoencephalic and placental barriers. In a liver is exposed to metabolism by dimethylation and oxidation. The main active metabolite of drug is Ambroxol. An elimination half-life – 15 hours. It is removed by kidneys. It can kumulirovatsya. Bromhexine is emitted with urine, mainly, in the form of metabolites. In not changed view with urine only a small amount of drug is allocated.
Pharmacodynamics. Bromhexine - mucolytic (sekretolitichesky) means, has expectorant and weak antibechic effect. Reduces viscosity of a phlegm (depolirizut mucoprotein and mukopolisakharidny fibers, increases a serous component of a bronchial secret), activates a ciliary epithelium, increases volume and improves otkhozhdeny phlegms. Stimulates production of the endogenous surfactant providing stability of alveolar cells in the course of breath. The effect is shown in 2-5 days from an initiation of treatment.
Indications to use:
The acute and chronic diseases of lungs which are followed by formation of a phlegm of the increased viscosity:
- bronchitis of a different etiology (including complicated by bronchiectasias);
- pneumonia;
- in the preoperative period (for the prevention of accumulation in bronchial tubes of a viscous phlegm after operation).
Route of administration and doses:
Inside, after food with enough liquid.
In the course of treatment it is recommended to use enough liquid that supports sekretolitichesky action of Bromhexine.
The adult appoint (8-16 mg) 2-4 teaspoons 3 times a day.
5 ml of drug (1 teaspoon) contain 4 mg of Bromhexine of a hydrochloride.
If necessary the dose can be increased by the adult to 16 mg 4 times a day, i.e., max. time. the dose sostavlat 16 mg; max. days dose of 64 mg.
Therapeutic action can be shown for 4-6 day of treatment.
Duration of a course of treatment is determined by the attending physician.
The patient should see a doctor if his state did not improve during 6 - day treatment by Bromhexine.
Features of use:
With care to apply at the patients having bronchial asthma at a renal and liver failure, and also at instructions on gastric bleeding.
Bromhexine should be applied with care to the weakened patient, and also patients with mechanical narrowing of bronchial tubes (the complicated expectoration of a secret of bronchial tubes).
In the course of treatment it is necessary to use enough liquid that increases expectorant effect of Bromhexine.
Considering what drug contains alcohol. It is necessary to be careful when driving or potentially dangerous mechanisms.
Side effects:
- dispepsichesky phenomena;
- aggravation of a peptic ulcer;
- allergic reactions (skin rash, face edema, rhinitis, etc.);
- cough, bronchospasm;
- the increased sweating;
- increase in activity of hepatic transaminases in blood serum.
Interaction with other medicines:
It is possible to appoint Bromhexine along with other drugs used at treatment of bronchopulmonary diseases.
Bromhexine is not appointed along with other antibechic drugs, including, containing codeine as suppression of a tussive reflex complicates otkhozhdeny phlegms.
Bromhexine promotes penetration of antibiotics (erythromycin, cefalexin, Oxytetracyclinum) into pulmonary fabric.
The alcohol which is a part of syrup can change effect of other medicines.
Combined use of Bromhexine with some non-steroidal anti-inflammatory drugs (for example, salicylates, phenylbutazone or Butadionum) can cause irritation mucous a stomach.
Bromhexine is incompatible with alkaline solutions.
Contraindications:
- hypersensitivity to drug components, including to sorbite;
- alcoholism;
- epilepsy;
- children's and teenage age do18 years;
- pregnancy, lactation period.
Overdose:
Symptoms: strengthening of symptoms of side effects (pain in epigastric area, nausea, vomiting).
Treatment: artificial vomiting, a gastric lavage (in the first 1-2 h after reception).
Storage conditions:
To store in the dry, protected from light place, at a temperature not above 25 °C.
To store in the place, unavailable to children!
Issue conditions:
Without recipe
Packaging:
On 120 g in the bottles from glass melt corked by the screwed metal caps with a control ring.
Each bottle together with the approved instruction on a medical use in the state and Russian languages and a dosing spoon is placed in a pack from a cardboard.
