Остенил®

General characteristics. Structure:

Active ingredient: 10 mg of sodium of hyalrunate in 1 ml of isotonic solution.

Excipients: sodium chloride, моногидрогенфосфат sodium, дигидрогенфосфат sodium, water for injections.

Ostenil is the original means on the basis of hyaluronic acid applied to local therapy of an osteoarthrosis of the I-III degree of knee, coxofemoral and humeral joints including a traumatic origin, and also at secondary arthroses at patients with arthritises of various genesis in a remission stage. Drug is developed and is produced since 1997 by the German-Swiss company TRB CHEMEDICA, the world leader in production of drugs on the basis of hyaluronic acid.

Pharmacological properties:

Pharmacodynamics. Synovial fluid which is viscoelastic because of presence of hyaluronic acid is found in all synovial joints, in particular in the heavy bearing joints where it provides the normal painless movement because of the greasing and shock-absorbing properties. She is also responsible for cartilage food.

In case of the frustration connected with the injured joints, for example osteoarthroses, viscoelasticity of synovial fluid is considerably reduced that reduces the greasing and shock-absorbing functions. It leads to increase in mechanical load of a joint and destruction of a cartilage that, eventually, leads to pain and limited mobility of the injured joint.

Addition of synovial fluid by means of intra joint injections of high cleaning hyaluronic acid can increase viscoelastic properties of synovial fluid. It increases the greasing and shock-absorbing functions and reduces mechanical load of a joint. As a rule, it leads to reduction of pain and increase in mobility of a joint which can last within, at least, several months after the medical cycle including five intra joint injections.

Indications to use:

Intra joint introduction of Ostenil is shown at pains and limited mobility at degenerative and dystrophic and traumatic changes of a hip, knee joint and other synovial joints.

Route of administration and doses:

Injections Ostenil become in a sore joint weekly, but only no more than 3 - 5 injections (Ostenil-mini: 1-3 injections). It is at the same time possible to treat several joints. Depending on gravity of a disease of joints, positive effect from the medical cycle including five intra joint injections within, at least, six months.

Recycles of treatment can be carried out on demand. In case of existence of an exudate in a joint it is recommended to reduce its volume by removal of liquid from a cavity, rest, use of ice and/or an intra joint injection of a corticosteroid. Treatment by Ostenil can be begun through two – three days. Contents and the external surface of in advance filled Ostenil's syringe keep sterility until the package is broken off.

Take out in advance filled syringe from packaging, remove Luer cap from the syringe, put on the necessary cannula (for example, 19 or 21 G) and fix it, having slightly turned. Before an injection release vials of air from the syringe.

Features of use:

The special attention is necessary for the patients suffering from hypersensitivity in relation to drugs. It is necessary to observe general measures of precaution for intra joint injections.

Ostenil has to be entered into a joint cavity accurately. It is necessary not to allow hits of drug in blood vessels or surrounding fabrics!

As children have no clinical data on use of hyaluronic acid, Ostenil is not recommended to use by pregnant women and nursing mothers, and also the patients having inflammatory diseases, for example, of a pseudorheumatism or Bekhterev's disease.

Do not use drug if in advance filled syringe or sterile packaging are damaged.

Intra joint administration of drug is carried out only by the specialist doctor!

Side effects:

The local secondary phenomena, such as pains, caumesthesia, reddening and swelling can be observed on a joint into which Ostenil is entered. Imposing of ice on a joint during five — will be removed ten minutes by all similar phenomena.

Interaction with other medicines:

There are no data concerning Ostenil's incompatibility with other solutions for intra joint use today. For simplification of a condition of the patient can take oral analgeziruyushchy means or antiinflammatory medicine during the several first days of procedures.

Contraindications:

Ostenil should not be used by the patients suffering from pronounced sensitivity to one of components.

Storage conditions:

To store at a temperature below 25 °C! Not to use after the expiry date specified on a box. You store in the place unavailable to children.

Issue conditions:

Without recipe

Packaging:

One in advance filled syringe of 20 mg / 2.0 ml of Ostenil (10 mg / 1.0 ml of Ostenila-mini) in sterile packaging. Ostenil is means of medical prescription. It is sterilized by autoclaving.