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medicalmeds.eu Medicines Antifungal means. Candide

Candide

Препарат Кандид. Glenmark Pharmaceuticals Ltd.(Гленмарк Фармасьютикалз Лтд) Индия


Producer: Glenmark Pharmaceuticals Ltd. (Glenmark Pharmasyyutikalz Ltd) India

Code of automatic telephone exchange: G01AF02

Release form: Firm dosage forms. Tablets are vaginal.

Indications to use: Vulvovaginitis. Trichomoniasis. Sanitation of patrimonial ways.


General characteristics. Structure:

Active agent: Clotrimazolum of 500 mg

Excipients: lactose, starch, the sodium carboxymethylstarch, talc purified magnesium stearate, silicon dioxide colloid, methylparahydroxybenzoate (methylparaben), пропилпарагидроксибензоат (propylparaben).




Pharmacological properties:

Candide is antifungal broad-spectrum agent for topical administration. The anti-mycotic effect of active active ingredient of Clotrimazolum (derivative an imidazole) is connected with disturbance of synthesis of the ergosterol which is a part of a cellular membrane of mushrooms that changes permeability of a membrane and causes the subsequent lysis of a cell. In small concentration affects fungistaticly, and in big - fungitsidno, and not only proliferating cells. In fungicidal concentration interacts with mitochondrial and peroksidazny enzymes therefore there is an increase in concentration of peroxide of hydrogen up to toxic level that also promotes destruction of fungal cells.
It is effective concerning dermatophytes, drozhzhepodobny and mold mushrooms, and also the activator multi-colored depriving (Pityriasis versicolor) and the activator of an erythrasma. Has antimicrobic effect concerning gram-positive (staphylococcus, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), and also concerning Trichomonas vaginalis.

Pharmacokinetics. At use of Clotrimazolum intravaginalno absorption makes 3-10% of the entered dose. High concentration in a vaginal secret and low concentration in blood remain within 48-72 hours. In a liver it is quickly metabolized to inactive metabolites.


Indications to use:

- the genital infections caused by drozhzhepodobny mushrooms of the sort Candida and/or Trichomonas vaginalis (a candidosis vulvovaginitis, trichomoniasis);
- the genital superinfections caused by the microorganisms sensitive to Clotrimazolum;
- sanitation of patrimonial ways before childbirth.


Route of administration and doses:

Locally. Only for intravaginalny use.
Vaginal tablets on 500 mg enter once in the evening into a vagina as it is possible more deeply, in a dorsal decubitus at slightly bent legs. The repeated course of treatment is possible after consultation of the doctor.


Features of use:

Prevention of urogenital reinfection requires simultaneous treatment of sexual partners. At trichomoniasis together with Kandid it is necessary to apply other medicines possessing systemic action to more successful treatment (for example, metronidazole inside). At a simultaneous infection of vulvar lips and adjacent sites (a candidosis vulvitis) it is necessary to carry out in addition topical treatment by Candide's drug cream.
During pregnancy treatment by vaginal tablets should be carried out without applicator. At patients with a liver failure it is necessary to control a functional condition of a liver periodically. At emergence of signs of hypersensitivity or irritation treatment is stopped. In the absence of effect within 4 weeks it is necessary to confirm the diagnosis.


Side effects:

Itch, burning and hypostasis of a mucous membrane of a vagina, allocation from a vagina, a headache, a gastralgia, the speeded-up urination, intercurrent cystitis, a burning sensation in a penis at the sexual partner, pain during sexual intercourse.


Interaction with other medicines:

At vaginal introduction Clotrimazolum reduces activity of Amphotericinum In and other half-yen antibiotics. At simultaneous use with nystatin activity of Clotrimazolum can decrease.


Contraindications:

Hypersensitivity to Clotrimazolum or excipients, the I trimester of pregnancy.
It is necessary to avoid use of tablets in the period of periods.

With care – the lactation period

Use during pregnancy and during feeding by a breast
At clinical and pilot studies it was not established that use of drug during pregnancy or during feeding by a breast exerts negative impact on health of the woman or a fruit (child). However the issue of expediency of purpose of drug has to be resolved individually after consultation of the doctor.


Overdose:

Use of drug in the raised doses does not cause any reactions and states, life-threatening.
In case of unforeseen use of drug the following symptoms are (inside) possible: anorexia, nausea, vomiting, gastralgia, abnormal liver function; seldom – drowsiness, hallucinations, a pollakiuria, skin allergiichseky reactions.
There is no specific antidote. It is necessary to appoint to vnut absorbent carbon. If necessary symptomatic treatment.


Storage conditions:

At a temperature not above 25 °C, in the dry, protected from light place. In the place, unavailable to children.


Issue conditions:

Without recipe


Packaging:

Vaginal tablets of 500 mg.
On 1 tablet in planimetric bezyacheykovy packaging (strip) from aluminum foil; 1 strip with the applicator and the application instruction in a cardboard pack.



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